Lee, Frank S.

HIF-1α binding to VHL is regulated by stimulus-sensitive proline hydroxylation

Yu, F., White, S. B., Zhao, Q., & Lee, F. S. (2001) · Proceedings of the National Academy of Sciences

Cancer, Hypoxia, and MetabolismUbiquitin and proteasome pathways

Cited by 796

A family with erythrocytosis establishes a role for prolyl hydroxylase domain protein 2 in oxygen homeostasis

Percy, M. J., Zhao, Q., Flores, A., Harrison, C., Lappin, T. R. J., Maxwell, P. H., McMullin, M. F., & Lee, F. S. (2006) · Proceedings of the National Academy of Sciences

Erythropoietin and Anemia TreatmentCancer, Hypoxia, and Metabolism

Cited by 330

A Gain-of-Function Mutation in the HIF2A Gene in Familial Erythrocytosis

Percy, M. J., Furlow, P. W., Lucas, G. S., Li, X., Lappin, T. R. J., McMullin, M. F., & Lee, F. S. (2008) · New England Journal of Medicine

Erythropoietin and Anemia TreatmentCancer, Hypoxia, and Metabolism

Cited by 314

Sequence determinants in hypoxia-inducible factor-1α for hydroxylation by the prolyl hydroxylases PHD1, PHD2, and PHD3

Huang, J., Zhao, Q., Mooney, S. M., & Lee, F. S. (2002) · Journal of Biological Chemistry

Cancer, Hypoxia, and MetabolismMetal-Catalyzed Oxygenation Mechanisms

Cited by 307

Regulation of adult erythropoiesis by prolyl hydroxylase domain proteins

Takeda, K., Aguila, H. L., Parikh, N. S., Li, X., Lamothe, K., Duan, L.-J., Takeda, H., Lee, F. S., & Fong, G.-H. (2008) · Blood

Erythropoietin and Anemia TreatmentCancer, Hypoxia, and Metabolism

Cited by 263

The HIF pathway and erythrocytosis

Lee, F. S., & Percy, M. J. (2011) · Annual Review of Pathology Mechanisms of Disease

Erythropoietin and Anemia TreatmentCancer, Hypoxia, and Metabolism

Cited by 177

A novel erythrocytosis-associated PHD2 mutation suggests the location of a HIF binding groove

Percy, M. J., Furlow, P. W., Beer, P. A., Lappin, T. R. J., McMullin, M. F., & Lee, F. S. (2007) · Blood

Erythropoietin and Anemia TreatmentCancer, Hypoxia, and Metabolism

Cited by 155

Novel exon 12 mutations in the HIF2A gene associated with erythrocytosis

Percy, M. J., Beer, P. A., Campbell, G., Dekker, A. W., Green, A. R., Oscier, D., Rainey, M. G., van Wijk, R., Wood, M., Lappin, T. R. J., et al. (2008) · Blood

Erythropoietin and Anemia TreatmentCancer, Hypoxia, and Metabolism

Cited by 127

Erythrocytosis-associated HIF-2α Mutations Demonstrate a Critical Role for Residues C-terminal to the Hydroxylacceptor Proline

Furlow, P. W., Percy, M. J., Sutherland, S., Bierl, C., McMullin, M. F., Master, S. R., Lappin, T. R. J., & Lee, F. S. (2009) · Journal of Biological Chemistry

Erythropoietin and Anemia TreatmentCancer, Hypoxia, and Metabolism

Cited by 58

Erythrocytosis associated with a novel missense mutation in the HIF2A gene

van Wijk, R., Sutherland, S., Van Wesel, A. C. W., Huizinga, E. G., Percy, M. J., Bierings, M., & Lee, F. S. (2010) · Haematologica

Erythropoietin and Anemia TreatmentCancer, Hypoxia, and Metabolism

Cited by 38

Two new mutations in the HIF2A gene associated with erythrocytosis

Percy, M. J., Chung, Y. J., Harrison, C., Mercieca, J., Hoffbrand, A. V., Dinardo, C. L., Santos, P. C. J. L., Fonseca, G. H. H., Gualandro, S. F. M., Pereira, A. C., et al. (2012) · American Journal of Hematology

Erythropoietin and Anemia TreatmentCancer, Hypoxia, and Metabolism

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