Iwasaki, Akiko

Guidelines for the use and interpretation of assays for monitoring autophagy

Klionsky, D. J., Abdalla, F. C., Abeliovich, H., Abraham, R. T., Acevedo-Arozena, A., Adeli, K., Agholme, L., Agnello, M., Agostinis, P., Aguirre-Ghiso, J. A., et al. (2012) · Autophagy

Autophagy in Disease and TherapyCalcium signaling and nucleotide metabolism

Cited by 3,996

Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes

Klionsky, D. J., Abeliovich, H., Agostinis, P., Agrawal, D. K., Aliev, G., Askew, D. S., Baba, M., Baehrecke, E. H., Bahr, B. A., Ballabio, A., et al. (2008) · Autophagy

Autophagy in Disease and TherapyCellular transport and secretion

Cited by 2,230

Control of adaptive immunity by the innate immune system

Iwasaki, A., & Medzhitov, R. (2015) · Nature Immunology

Immune Response and InflammationImmunotherapy and Immune Responses

Cited by 2,160

Longitudinal analyses reveal immunological misfiring in severe COVID-19

Lucas, C., Wong, P., Klein, J., Castro, T. B. R., Silva, J., Sundaram, M., Ellingson, M. K., Mao, T., Oh, J. E., Israelow, B., et al. (2020) · Nature

COVID-19 Clinical Research StudiesSARS-CoV-2 and COVID-19 Research

Cited by 2,074

Mitochondrial DNA stress primes the antiviral innate immune response

West, A. P., Khoury-Hanold, W., Staron, M., Tal, M. C., Pineda, C. M., Lang, S. M., Bestwick, M., Duguay, B. A., Raimundo, N., MacDuff, D. A., et al. (2015) · Nature

interferon and immune responsesImmune Response and Inflammation

Cited by 1,975

Microbiota regulates immune defense against respiratory tract influenza A virus infection

Ichinohe, T., Pang, I. K., Kumamoto, Y., Peaper, D. R., Ho, J. H., Murray, T. S., & Iwasaki, A. (2011) · Proceedings of the National Academy of Sciences

Immune Response and InflammationGut microbiota and health

Cited by 1,502

Sex differences in immune responses that underlie COVID-19 disease outcomes

Takahashi, T., Ellingson, M. K., Wong, P., Israelow, B., Lucas, C., Klein, J., Silva, J., Mao, T., Oh, J. E., Tokuyama, M., et al. (2020) · Nature

COVID-19 Clinical Research StudiesSARS-CoV-2 and COVID-19 Research

Cited by 1,459

Neuroinvasion of SARS-CoV-2 in human and mouse brain

Song, E., Zhang, C., Israelow, B., Lu-Culligan, A., Prado, A. V., Skriabine, S., Lu, P., Weizman, O.-E., Liu, F., Dai, Y., et al. (2020) · The Journal of Experimental Medicine

Long-Term Effects of COVID-19SARS-CoV-2 and COVID-19 Research

Cited by 1,064

Type I and Type III Interferons – Induction, Signaling, Evasion, and Application to Combat COVID-19

Park, A., & Iwasaki, A. (2020) · Cell Host & Microbe

interferon and immune responsesSARS-CoV-2 and COVID-19 Research

Cited by 909

Apoptotic Caspases Prevent the Induction of Type I Interferons by Mitochondrial DNA

Rongvaux, A., Jackson, R., Harman, C. C. D., Li, T., West, A. P., de Zoete, M. R., Wu, Y., Yordy, B., Lakhani, S. A., Kuan, C.-Y., et al. (2014) · Cell

interferon and immune responsesCell death mechanisms and regulation

Cited by 847

Unexplained post-acute infection syndromes

Choutka, J., Jansari, V., Hornig, M., & Iwasaki, A. (2022) · Nature Medicine

Long-Term Effects of COVID-19Infectious Encephalopathies and Encephalitis

Cited by 604

Long COVID science, research and policy

Al-Aly, Z., Davis, H., McCorkell, L., Soares, L., Wulf-Hanson, S., Iwasaki, A., & Topol, E. J. (2024) · Nature Medicine

Long-Term Effects of COVID-19COVID-19 Clinical Research Studies

Cited by 538

Mild respiratory COVID can cause multi-lineage neural cell and myelin dysregulation

Fernández-Castañeda, A., Lu, P., Geraghty, A. C., Song, E., Lee, M.-H., Wood, J., O’Dea, M. R., Dutton, S., Shamardani, K., Nwangwu, K., et al. (2022) · Cell

Long-Term Effects of COVID-19Neuroinflammation and Neurodegeneration Mechanisms

Cited by 521

In vivo requirement for Atg5 in antigen presentation by dendritic cells

Lee, H. K., Mattei, L. M., Steinberg, B. E., Alberts, P., Lee, Y. H., Chervonsky, A., Mizushima, N., Grinstein, S., & Iwasaki, A. (2010) · Immunity

Autophagy in Disease and TherapyImmunotherapy and Immune Responses

Cited by 506

Sensing Self and Foreign Circular RNAs by Intron Identity

Chen, Y. G., Kim, M. V., Chen, X., Batista, P. J., Aoyama, S., Wilusz, J. E., Iwasaki, A., & Chang, H. Y. (2017) · Molecular Cell

Circular RNAs in diseasesinterferon and immune responses

Cited by 475

A local macrophage chemokine network sustains protective tissue-resident memory CD4 T cells

Iijima, N., & Iwasaki, A. (2014) · Science

T-cell and B-cell ImmunologyHerpesvirus Infections and Treatments

Cited by 420

The neurobiology of long COVID

Monje, M., & Iwasaki, A. (2022) · Neuron

Long-Term Effects of COVID-19Traumatic Brain Injury Research

Cited by 415

Mouse model of SARS-CoV-2 reveals inflammatory role of type I interferon signaling

Israelow, B., Song, E., Mao, T., Lu, P., Meir, A., Liu, F., Alfajaro, M. M., Wei, J., Dong, H., Homer, R. J., et al. (2020) · Journal of Experimental Medicine

SARS-CoV-2 and COVID-19 Researchinterferon and immune responses

Cited by 415

Neutralizing antibodies against the SARS-CoV-2 Delta and Omicron variants following heterologous CoronaVac plus BNT162b2 booster vaccination

Pérez-Then, E., Lucas, C., Monteiro, V. S., Miric, M., Brache, V., Cochon, L., Vogels, C. B. F., Malik, A. A., De la Cruz, E., Jorge, A., et al. (2022) · Nature Medicine

SARS-CoV-2 and COVID-19 ResearchAnimal Virus Infections Studies

Cited by 401

β-hydroxybutyrate deactivates neutrophil NLRP3 inflammasome to relieve gout flares

Goldberg, E. L., Asher, J. L., Molony, R. D., Shaw, A. C., Zeiss, C. J., Wang, C., Morozova-Roche, L. A., Herzog, R. I., Iwasaki, A., & Dixit, V. D. (2017) · Cell Reports

Inflammasome and immune disordersGout, Hyperuricemia, Uric Acid

Cited by 370

The autophagy gene ATG5 plays an essential role in B lymphocyte development

Miller, B. C., Zhao, Z., Stephenson, L. M., Cadwell, K., Pua, H. H., Lee, H. K., Mizushima, N., Iwasaki, A., He, Y.-W., Swat, W., et al. (2008) · Autophagy

Autophagy in Disease and TherapyT-cell and B-cell Immunology

Cited by 352

Noncanonical Autophagy Is Required for Type I Interferon Secretion in Response to DNA-Immune Complexes

Henault, J., Martinez, J., Riggs, J. M., Tian, J., Mehta, P., Clarke, L., Sasai, M., Latz, E., Brinkmann, M. M., Iwasaki, A., et al. (2012) · Immunity

Immune Response and InflammationAutophagy in Disease and Therapy

Cited by 348

KDM5B promotes immune evasion by recruiting SETDB1 to silence retroelements

Zhang, S.-M., Cai, W. L., Liu, X., Thakral, D., Luo, J., Chan, L. H., McGeary, M. K., Song, E., Blenman, K. R. M., Micevic, G., et al. (2021) · Nature

Cancer Immunotherapy and BiomarkersEpigenetics and DNA Methylation

Cited by 272

Single-cell longitudinal analysis of SARS-CoV-2 infection in human airway epithelium identifies target cells, alterations in gene expression, and cell state changes

Ravindra, N. G., Alfajaro, M. M., Gasque, V., Huston, N. C., Wan, H., Szigeti-Buck, K., Yasumoto, Y., Greaney, A. M., Habet, V., Chow, R. D., et al. (2021) · PLOS Biology

SARS-CoV-2 and COVID-19 ResearchCOVID-19 Clinical Research Studies

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