de Bruin, Alain

Restricted diet delays accelerated ageing and genomic stress in DNA-repair-deficient mice

Vermeij, W. P., Dollé, M. E. T., Reiling, E., Jaarsma, D., Payan-Gomez, C., Bombardieri, C. R., Wu, H., Roks, A. J. M., Botter, S. M., van der Eerden, B. C., et al. (2016) · Nature

Genetics, Aging, and Longevity in Model OrganismsDietary Effects on Health

Cited by 315

Identification and Characterization of E2F7, a Novel Mammalian E2F Family Member Capable of Blocking Cellular Proliferation

de Bruin, A., Maiti, B., Jakoi, L., Timmers, C., Buerki, R., & Leone, G. (2003) · Journal of Biological Chemistry

Cancer-related Molecular PathwaysGenomics and Chromatin Dynamics

Cited by 221

E2F8 is essential for polyploidization in mammalian cells

Pandit, S. K., Westendorp, B., Nantasanti, S., van Liere, E., Tooten, P. C. J., Cornelissen, P. W. A., Toussaint, M. J. M., Lamers, W. H., & de Bruin, A. (2012) · Nature Cell Biology

Liver physiology and pathologyCancer-related Molecular Pathways

Cited by 168

E2f8 mediates tumor suppression in postnatal liver development

Kent, L. N., Rakijas, J. B., Pandit, S. K., Westendorp, B., Chen, H.-Z., Huntington, J. T., Tang, X., Bae, S., Srivastava, A., Senapati, S., et al. (2016) · Journal of Clinical Investigation

Cancer-related Molecular PathwaysLiver physiology and pathology

Cited by 95

T cell cholesterol efflux suppresses apoptosis and senescence and increases atherosclerosis in middle aged mice

Bazioti, V., La Rose, A. M., Maassen, S., Bianchi, F., de Boer, R., Halmos, B., Dabral, D., Guilbaud, E., Flohr-Svendsen, A., Groenen, A. G., et al. (2022) · Nature Communications

Atherosclerosis and Cardiovascular DiseasesCholesterol and Lipid Metabolism

Cited by 65

E2F7 Is a Potent Inhibitor of Liver Tumor Growth in Adult Mice

Moreno, E., Toussaint, M. J. M., van Essen, S. C., Bongiovanni, L., van Liere, E. A., Koster, M. H., Yuan, R., van Deursen, J. M., Westendorp, B., & de Bruin, A. (2021) · Hepatology

Cancer-related Molecular PathwaysLiver physiology and pathology

Cited by 37

DNAJB6b-enriched small extracellular vesicles decrease polyglutamine aggregation in in vitro and in vivo models of Huntington disease

Joshi, B. S., Youssef, S. A., Bron, R., de Bruin, A., Kampinga, H. H., & Zuhorn, I. S. (2021) · iScience

Genetic Neurodegenerative DiseasesExtracellular vesicles in disease

Cited by 31

Atypical E2f functions are critical for pancreas polyploidization

Matondo, R. B., Moreno, E., Toussaint, M. J. M., Tooten, P. C. J., van Essen, S. C., van Liere, E. A., Youssef, S. A., Bongiovanni, L., & de Bruin, A. (2018) · PLOS ONE

Pancreatic function and diabetesDevelopmental Biology and Gene Regulation

Cited by 14