Restricted diet delays accelerated ageing and genomic stress in DNA-repair-deficient mice
Open accessAbstract
Mice deficient in the DNA excision-repair gene Ercc1 (Ercc1∆/-) show numerous accelerated ageing features that limit their lifespan to 4-6 months. They also exhibit a 'survival response', which suppresses growth and enhances cellular maintenance. Such a response resembles the anti-ageing response induced by dietary restriction (also known as caloric restriction). Here we report that a dietary restriction of 30% tripled the median and maximal remaining lifespans of these progeroid mice, strongly retarding numerous aspects of accelerated ageing. Mice undergoing dietary restriction retained 50% more neurons and maintained full motor function far beyond the lifespan of mice fed ad libitum. Other DNA-repair-deficient, progeroid Xpg-/- (also known as Ercc5-/-) mice, a model of Cockayne syndrome, responded similarly. The dietary restriction response in Ercc1∆/- mice closely resembled the effects of dietary restriction in wild-type animals. Notably, liver tissue from Ercc1∆/- mice fed ad libitum showed preferential extinction of the expression of long genes, a phenomenon we also observed in several tissues ageing normally. This is consistent with the accumulation of stochastic, transcription-blocking lesions that affect long genes more than short ones. Dietary restriction largely prevented this declining transcriptional output and reduced the number of γH2AX DNA damage foci, indicating that dietary restriction preserves genome function by alleviating DNA damage. Our findings establish the Ercc1∆/- mouse as a powerful model organism for health-sustaining interventions, reveal potential for reducing endogenous DNA damage, facilitate a better understanding of the molecular mechanism of dietary restriction and suggest a role for counterintuitive dietary-restriction-like therapy for human progeroid genome instability syndromes and possibly neurodegeneration in general.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Calorie restriction dramatically delays premature ageing in DNA repair mutant mice, likely by decreasing ROS and other reactive compounds and thereby reducing DNA damage.
“CR dramatically delays premature ageing in DNA repair mutant mice likely by decreased levels of ROS and other reactive compounds leading to reduced DNA damage levels43.”
From The central role of DNA damage in the ageing process (2021) · cites this paper as [43]
If replication forks or transcription complexes encounter polymerase-blocking lesions, this can lead to formation of a DSB or R-loop, which potently activate signaling events that halt cell cycle progression and promote repair.
“If replication forks or transcription complexes encounter polymerase-blocking lesions (Vermeij et al., 2016), this can lead to the formation of a DSB or R-loop (Tresini et al., 2015), which potently activate signaling events that halt cell cycle progression and promote repair.”
From DNA damage-how and why we age? (2021) · cites this paper as Vermeij et al., 2016
Recent work using an NER-deficient mouse model provided evidence that metabolically induced DNA damage, in the absence of repair, blocks gene transcription and results in accelerated aging.
“Recent work using an NER-deficient mouse model provided evidence demonstrating the participation of metabolically induced DNA damage, which, in the absence of repair, blocks gene transcription and results in accelerated aging [214].”
From Sunlight damage to cellular DNA: focus on oxidatively generated lesions (2017) · cites this paper as [214]
In mice subjected to CR, 50% more neurons and full motor function are retained.
“In mice subjected to CR, 50% more neurons and full motor function are retained.489”
From Antiageing strategy for neurodegenerative diseases: from mechanisms to clinical advances (2025) · cites this paper as [489]
CR triples median and maximal remaining lifespans of progeroid mice, strongly retarding numerous aspects of accelerated ageing.
“CR triples the median and maximal remaining lifespans of progeroid mice, strongly retarding numerous aspects of accelerated ageing.”
From Antiageing strategy for neurodegenerative diseases: from mechanisms to clinical advances (2025) · cites this paper as [489]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013) · Cell · doi:10.1016/j.cell.2013.05.039 · Cited by 14,982 · see citing works
The senescence-associated secretory phenotype: the dark side of tumor suppression
Coppé, J.-P., Desprez, P.-Y., Krtolica, A., & Campisi, J. (2010) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathol-121808-102144 · Cited by 5,206 · see citing works
Mapping identifiers for the integration of genomic datasets with the R/Bioconductor package biomaRt
Durinck, S., Spellman, P. T., Birney, E., & Huber, W. K. (2009) · Nature Protocols · doi:10.1038/nprot.2009.97 · Cited by 4,081 · see citing works
Extending Healthy Life Span—From Yeast to Humans
Fontana, L., Partridge, L., & Longo, V. D. (2010) · Science · doi:10.1126/science.1172539 · Cited by 3,023 · see citing works
A microRNA component of the p53 tumour suppressor network
He, L., He, X., Lim, L. P., de Stanchina, E., Xuan, Z., Liang, Y., Xue, W., Zender, L., Magnus, J., Ridzon, D., et al. (2007) · Nature · doi:10.1038/nature05939 · Cited by 2,692 · see citing works
What is principal component analysis?
Ringnér, M. (2008) · Nature Biotechnology · doi:10.1038/nbt0308-303 · Cited by 2,407 · see citing works
Caloric Restriction Delays Disease Onset and Mortality in Rhesus Monkeys
Colman, R. J., Anderson, R. M., Johnson, S. C., Kastman, E. K., Kosmatka, K. J., Beasley, T. M., Allison, D. B., Cruzen, C., Simmons, H. A., Kemnitz, J. W., et al. (2009) · Science · doi:10.1126/science.1173635 · Cited by 2,277 · see citing works
Hoeijmakers, J. H. J. (2009) · New England Journal of Medicine · doi:10.1056/nejmra0804615 · Cited by 2,239 · see citing works
Self-citationUnderstanding nucleotide excision repair and its roles in cancer and ageing
Marteijn, J. A., Lans, H., Vermeulen, W., & Hoeijmakers, J. H. J. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3822 · Cited by 1,192 · see citing works
Self-citationThe Critical Role of Metabolic Pathways in Aging
Barzilai, N., Huffman, D. M., Muzumdar, R. H., & Bartke, A. (2012) · Diabetes · doi:10.2337/db11-1300 · Cited by 803 · see citing works
Speakman, J. R., & Mitchell, S. E. (2011) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2011.07.001 · Cited by 769 · see citing works
A new progeroid syndrome reveals that genotoxic stress suppresses the somatotroph axis
Niedernhofer, L. J., Garinis, G. A., Raams, A., Lalai, A. S., Robinson, A. R., Appeldoorn, E., Odijk, H., Oostendorp, R., Ahmad, A., van Leeuwen, W., et al. (2006) · Nature · doi:10.1038/nature05456 · Cited by 669 · see citing works
Self-citationHalagappa, V. K. M., Guo, Z., Pearson, M., Matsuoka, Y., Cutler, R. G., LaFerla, F. M., & Mattson, M. P. (2007) · Neurobiology of Disease · doi:10.1016/j.nbd.2006.12.019 · Cited by 580 · see citing works
Demography of Dietary Restriction and Death in Drosophila
Mair, W. B., Goymer, P., Pletcher, S. D., & Partridge, L. (2003) · Science · doi:10.1126/science.1086016 · Cited by 526 · see citing works
The ploidy conveyor of mature hepatocytes as a source of genetic variation
Duncan, A. W., Taylor, M. H., Hickey, R. D., Hanlon Newell, A. E., Lenzi, M. L., Olson, S. B., Finegold, M. J., & Grompe, M. (2010) · Nature · doi:10.1038/nature09414 · Cited by 525 · see citing works
Gates, K. S. (2009) · Chemical Research in Toxicology · doi:10.1021/tx900242k · Cited by 489 · see citing works
Weeda, G., Donker, I., de Wit, J., Morreau, H., Janssens, R. C., Vissers, C. J., Nigg, A. L., STEEG, H. V., Bootsma, D., & Hoeijmakers, J. H. J. (1997) · Current Biology · doi:10.1016/s0960-9822(06)00190-4 · Cited by 380 · see citing works
Self-citationSwenberg, J. A., Lü, K., Moeller, B. C., Gao, L., Upton, P. B., Nakamura, J., & Starr, T. B. (2010) · Toxicological Sciences · doi:10.1093/toxsci/kfq371 · Cited by 377 · see citing works
Mutations in ERCC4, encoding the DNA-repair endonuclease XPF, cause Fanconi anemia.
Bogliolo, M., Schuster, B., Stoepker, C., Derkunt, B., Su, Y., Raams, A., Trujillo, J. P., Minguillón, J., Ramírez, M., Pujol, R., et al. (2013) · American Journal of Human Genetics · doi:10.1016/j.ajhg.2013.04.002 · Cited by 334 · see citing works
McWhir, J., Selfridge, J., Harrison, D. J., Squires, S., & Melton, D. W. (1993) · Nature Genetics · doi:10.1038/ng1193-217 · Cited by 322 · see citing works
Somatotropic Signaling: Trade-Offs Between Growth, Reproductive Development, and Longevity
Bartke, A., Sun, L. Y., & Longo, V. D. (2013) · Physiological Reviews · doi:10.1152/physrev.00006.2012 · Cited by 286 · see citing works
Cell Senescence: Role in Aging and Age-Related Diseases
Campisi, J., & Robert, L. (2014) · Interdisciplinary Topics in Gerontology and Geriatrics · doi:10.1159/000358899 · Cited by 240 · see citing works
van der Pluijm, I., Garinis, G. A., Brandt, R. M. C., Gorgels, T. G. M. F., Wijnhoven, S., Diderich, K. E. M., de Wit, J., Mitchell, J. R., van Oostrom, C., Beems, R. B., et al. (2006) · PLoS Biology · doi:10.1371/journal.pbio.0050002 · Cited by 237 · see citing works
Self-citationDelayed and Accelerated Aging Share Common Longevity Assurance Mechanisms
Schumacher, B., van der Pluijm, I., Moorhouse, M. J., Kosteas, T., Robinson, A. R., Suh, Y., Breit, T. M., van Steeg, H., Niedernhofer, L. J., van IJcken, W., et al. (2008) · PLoS Genetics · doi:10.1371/journal.pgen.1000161 · Cited by 212 · see citing works
Self-citationKashiyama, K., Nakazawa, Y., Pilz, D. T., Guo, C., Shimada, M., Sasaki, K., Fawcett, H., Wing, J., Lewin, S. O., Carr, L., et al. (2013) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2013.04.007 · Cited by 212 · see citing works
An Improved Segmentation Method for In Vivo μCT Imaging
Waarsing, J. H., Day, J. S., & Weinans, H. (2004) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.040705 · Cited by 212 · see citing works
miR-34 and p53: New Insights into a Complex Functional Relationship
Navarro, F., & Lieberman, J. (2015) · PLoS ONE · doi:10.1371/journal.pone.0132767 · Cited by 203 · see citing works
Nucleotide Excision DNA Repair Is Associated With Age-Related Vascular Dysfunction
Durik, M., Kavousi, M., van der Pluijm, I., Isaacs, A. J., Cheng, C., Verdonk, K., Loot, A. E., Oeseburg, H., Bhaggoe, U. M., Leijten, F. P. J., et al. (2012) · Circulation · doi:10.1161/circulationaha.112.104380 · Cited by 191 · see citing works
Self-citationWilson, B. T., Stark, Z., Sutton, R. E., Danda, S., Ekbote, A. V., Elsayed, S. M., Gibson, L., Goodship, J. A., Jackson, A. P., Keng, W. T., et al. (2015) · Genetics in Medicine · doi:10.1038/gim.2015.110 · Cited by 179 · see citing works
Swindell, W. R. (2009) · BMC Genomics · doi:10.1186/1471-2164-10-585 · Cited by 171 · see citing works
Priming of microglia in a DNA-repair deficient model of accelerated aging
Raj, D. D. A., Jaarsma, D., Holtman, I. R., Olah, M., Ferreira, F. M., Schaafsma, W., Brouwer, N., Meijer, M., de Waard, M. C., van der Pluijm, I., et al. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.03.025 · Cited by 144 · see citing works
Self-citationGarinis, G. A., Uittenboogaard, L. M., Stachelscheid, H., Fousteri, M., van Ijcken, W., Breit, T. M., van Steeg, H., Mullenders, L. H. F., van der Horst, G. T. J., Brüning, J. C., et al. (2009) · Nature Cell Biology · doi:10.1038/ncb1866 · Cited by 138 · see citing works
Self-citationBotter, S. M., Glasson, S. S., Hopkins, B., et al. (2008) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2008.09.018 · Cited by 134 · see citing works
Self-citationAccelerated Age-Related Cognitive Decline and Neurodegeneration, Caused by Deficient DNA Repair
Borgesius, N. Z., de Waard, M. C., van der Pluijm, I., Omrani, A., Zondag, G. C. M., van der Horst, G. T. J., Melton, D. W., Hoeijmakers, J. H. J., Jaarsma, D., & Elgersma, Y. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.1589-11.2011 · Cited by 126 · see citing works
Self-citationGenome Integrity in Aging: Human Syndromes, Mouse Models, and Therapeutic Options
Vermeij, W. P., Hoeijmakers, J. H. J., & Pothof, J. (2015) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010814-124316 · Cited by 123 · see citing works
Self-citationPartridge, L., & Gems, D. (2007) · Nature · doi:10.1038/450165a · Cited by 119 · see citing works
Age-related motor neuron degeneration in DNA repair-deficient Ercc1 mice
de Waard, M. C., van der Pluijm, I., Borgesius, N. Z., Comley, L. H., Haasdijk, E. D., Rijksen, Y., Ridwan, Y. R., Zondag, G. C. M., Hoeijmakers, J. H. J., Elgersma, Y., et al. (2010) · Acta Neuropathologica · doi:10.1007/s00401-010-0715-9 · Cited by 110 · see citing works
Self-citationBroad segmental progeroid changes in short-lived <i>Ercc1</i> <sup>−/Δ7</sup> mice
Dollé, M. E. T., Kuiper, R. V., Roodbergen, M., Robinson, J., de Vlugt, S., Wijnhoven, S. W. P., Beems, R. B., de la Fonteyne, L., de With, P., van der Pluijm, I., et al. (2011) · Pathobiology of Aging & Age-related Diseases · doi:10.3402/pba.v1i0.7219 · Cited by 91 · see citing works
Self-citationWijnhoven, S., Beems, R. B., Roodbergen, M., van den Berg, J., Lohman, P. H. M., Diderich, K. E. M., van der Horst, G. T. J., Vijg, J., Hoeijmakers, J. H. J., & STEEG, H. V. (2005) · DNA repair · doi:10.1016/j.dnarep.2005.07.002 · Cited by 70 · see citing works
Self-citationCell-Autonomous Progeroid Changes in Conditional Mouse Models for Repair Endonuclease XPG Deficiency
Barnhoorn, S., Uittenboogaard, L. M., Jaarsma, D., Vermeij, W. P., Tresini, M., Weymaere, M., Menoni, H., Brandt, R. M. C., de Waard, M. C., Botter, S. M., et al. (2014) · PLoS Genetics · doi:10.1371/journal.pgen.1004686 · Cited by 64 · see citing works
Self-citationJonker, M. J., Melis, J. P. M., Kuiper, R., van der Hoeven, T. V., Wackers, P. F. K., Robinson, J. E., van der Horst, G. T. J., Dollé, M. E. T., Vijg, J., Breit, T. M., et al. (2013) · Aging Cell · doi:10.1111/acel.12118 · Cited by 61 · see citing works
Self-citationCockayne syndrome pathogenesis: Lessons from mouse models
Jaarsma, D., van der Pluijm, I., van der Horst, G. T. J., & Hoeijmakers, J. H. J. (2013) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2013.04.003 · Cited by 57 · see citing works
Self-citationMetabolic Reserve as a Determinant of Cognitive Aging
Stranahan, A. M., & Mattson, M. P. (2012) · Journal of Alzheimer s Disease · doi:10.3233/jad-2011-110899 · Cited by 54 · see citing works
de Graaf, E. L., Vermeij, W. P., de Waard, M. C., Rijksen, Y., van der Pluijm, I., Hoogenraad, C. C., Hoeijmakers, J. H. J., Altelaar, M. A. F., & Heck, A. J. R. (2013) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m112.024950 · Cited by 35 · see citing works
Self-citationDeciphering the RNA landscape by RNAome sequencing
Derks, K., Mišovic, B., van den Hout, M. C. G. N., Kockx, C. E. M., Payán‐Gómez, C., Brouwer, R. W. W., Vrieling, H., Hoeijmakers, J. H. J., van IJcken, W. F. J., & Pothof, J. (2015) · RNA Biology · doi:10.1080/15476286.2015.1017202 · Cited by 26 · see citing works
Self-citation
Flagged first, then by citations
Research works printed but not linked: 1
- [38]Smyth GK Limma: linear models for microarray data Gentleman R Carey V Dudoit S Irizarry R Huber W Bioinformatics and Computational Biology Solutions Using R and Bioconductor 397 420 Springer New York 2005
Cited by
Sorted by citations
Sarcopenia: Aging-Related Loss of Muscle Mass and Function
Larsson, L., Degens, H., Li, M., Salviati, L., Lee, Y. I., Thompson, W., Kirkland, J. L., & Sandri, M. (2019) · Physiological Reviews · doi:10.1152/physrev.00061.2017 · Cited by 1,797 · see citing works
Hallmarks of Brain Aging: Adaptive and Pathological Modification by Metabolic States
Mattson, M. P., & Arumugam, T. V. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.05.011 · Cited by 1,242 · see citing works
The central role of DNA damage in the ageing process
Schumacher, B., Pothof, J., Vijg, J., & Hoeijmakers, J. H. J. (2021) · Nature · doi:10.1038/s41586-021-03307-7 · Cited by 907 · see citing works
Self-citationMolecular and physiological manifestations and measurement of aging in humans
Khan, S. S., Singer, B. D., & Vaughan, D. E. (2017) · Aging Cell · doi:10.1111/acel.12601 · Cited by 530 · see citing works
Sunlight damage to cellular DNA: focus on oxidatively generated lesions
Schuch, A. P., Moreno, N. C., Schuch, N. J., Menck, C. F. M., & Garcia, C. C. M. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2017.01.029 · Cited by 436 · see citing works
DNA damage-how and why we age?
Yousefzadeh, M., Henpita, C., Vyas, R., Soto-Palma, C., Robbins, P., & Niedernhofer, L. (2021) · eLife · doi:10.7554/elife.62852 · Cited by 399 · see citing works
The DNA damage response to transcription stress
Lans, H., Hoeijmakers, J. H. J., Vermeulen, W., & Marteijn, J. A. (2019) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-019-0169-4 · Cited by 321 · see citing works
Self-citationMethionine Restriction Extends Lifespan in Progeroid Mice and Alters Lipid and Bile Acid Metabolism
Bárcena, C., Quirós, P. M., Durand, S., Mayoral, P., Rodríguez, F., Caravia, X. M., Mariño, G., Garabaya, C., Fernández-García, M. T., Kroemer, G., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.07.089 · Cited by 185 · see citing works
Antiageing strategy for neurodegenerative diseases: from mechanisms to clinical advances
Jiang, Q., Liu, J., Huang, S., Wang, X.-Y., Chen, X., Liu, G.-H., Ye, K., Song, W., Masters, C. L., Wang, J., et al. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02145-7 · Cited by 165 · see citing works
Incorporation of a nucleoside analog maps genome repair sites in postmitotic human neurons
Reid, D. A., Reed, P. J., Schlachetzki, J. C. M., Nitulescu, I. I., Chou, G., Tsui, E. C., Jones, J. R., Chandran, S., Lu, A. T., McClain, C. A., et al. (2021) · Science · doi:10.1126/science.abb9032 · Cited by 121 · see citing works
Borggrewe, M., Grit, C., Den Dunnen, W. F. A., Burm, S. M., Bajramovic, J. J., Noelle, R. J., Eggen, B. J. L., & Laman, J. D. (2018) · Glia · doi:10.1002/glia.23517 · Cited by 91 · see citing works
Birkisdóttir, M. B., Jaarsma, D., Brandt, R. M. C., Barnhoorn, S., van Vliet, N., Imholz, S., van Oostrom, C. T., Nagarajah, B., Portilla Fernández, E., Roks, A. J. M., et al. (2021) · Aging Cell · doi:10.1111/acel.13302 · Cited by 35 · see citing works
Self-citationSodium rutin extends lifespan and health span in mice including positive impacts on liver health
Li, S., Li, J., Pan, R., Cheng, J., Cui, Q., Chen, J., & Yuan, Z. (2022) · British Journal of Pharmacology · doi:10.1111/bph.15410 · Cited by 36 · see citing works
DNA repair‐deficient premature aging models display accelerated epigenetic age
Perez, K., Parras, A., Picó, S., Rechsteiner, C., Haghani, A., Brooke, R., Mrabti, C., Schoenfeldt, L., Horvath, S., & Ocampo, A. (2024) · Aging Cell · doi:10.1111/acel.14058 · Cited by 31 · see citing works
ATP-dependent chromatin remodelers in ageing and age-related disorders
Swer, P. B., & Sharma, R. (2021) · Biogerontology · doi:10.1007/s10522-020-09899-3 · Cited by 25 · see citing works
Sunlight, Vitamin D, and Xeroderma Pigmentosum
Martens, M. C., Emmert, S., & Boeckmann, L. (2020) · Advances in Experimental Medicine and Biology · doi:10.1007/978-3-030-46227-7_16 · Cited by 24 · see citing works
Transcription Blockage by DNA Damage in Nucleotide Excision Repair-Related Neurological Dysfunctions
Kajitani, G. S., Nascimento, L. L. D. S., Neves, M. R. D. C., Leandro, G. D. S., Garcia, C. C. M., & Menck, C. F. M. (2021) · Seminars in Cell & Developmental Biology · doi:10.1016/j.semcdb.2020.10.009 · Cited by 22 · see citing works
Townley, B. A., Buerer, L., Tsao, N., Bacolla, A., Mansoori, F., Rusanov, T., Clark, N. E., Goodarzi, N., Schmidt, N., Srivatsan, S. N., et al. (2023) · Molecular Cell · doi:10.1016/j.molcel.2023.06.011 · Cited by 15 · see citing works
Recent advances in understanding the mechanisms determining longevity
Bayersdorf, R., & Schumacher, B. (2019) · F1000Research · doi:10.12688/f1000research.19610.1 · Cited by 14 · see citing works
Paine, P. T., Rechsteiner, C., Morandini, F., Desdín-Micó, G., Mrabti, C., Parras, A., Haghani, A., Brooke, R., Horvath, S., Seluanov, A., et al. (2024) · Frontiers in Aging · doi:10.3389/fragi.2023.1323194 · Cited by 13 · see citing works
Fifty years since DNA repair was linked to Cancer
Wood, R. D. (2018) · Nature · doi:10.1038/d41586-018-05255-1 · Cited by 9 · see citing works
- Authors
- Vermeij, W. P., Dollé, M. E. T., Reiling, E., Jaarsma, D., Payan-Gomez, C., Bombardieri, C. R., Wu, H., Roks, A. J. M., Botter, S. M., van der Eerden, B. C., Youssef, S. A., Kuiper, R. V., Nagarajah, B., van Oostrom, C. T., Brandt, R. M. C., Barnhoorn, S., Imholz, S., Pennings, J. L. A., de Bruin, A., Gyenis, Á., Pothof, J., Vijg, J., van Steeg, H., & Hoeijmakers, J. H. J.
- Affiliations
- Erasmus MC (NL)
- National Institute for Public Health and the Environment (NL)
- Utrecht University (NL)
- Albert Einstein College of Medicine (US)
- University of Cologne (DE)
- Corresponding author
- Dollé, M. E. T.
- Hoeijmakers, J. H. J.
- ORCID
- Venue
- Nature
- Published
- 2016-08-24
- Volume
- 537
- Issue
- 7620
- Pages
- 427-431
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC5161687
- OpenAlex
- W2511049107
- Cited by
- 315
- References
- 45
- Citations by year
- 2026: 22 · 2025: 28 · 2024: 42 · 2023: 32 · 2022: 45 · 2021: 31 · 2020: 27 · 2019: 31 · 2018: 30 · 2017: 23 · 2016: 4
- FWCI
- 15.88
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Kölner Universitäts PublikationsServer (Universität zu Köln) (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (publishedVersion)
- PubMed Central (acceptedVersion)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, other-oa)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
- RePub (Erasmus University Rotterdam) (submittedVersion, other-oa)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Leiden Repository (Leiden University) (submittedVersion)
- Utrecht University Repository (Utrecht University) (submittedVersion, other-oa)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
- Rivm (National Institute for Public Health and the Environment) (submittedVersion)
- Utrecht University Repository (Utrecht University) (submittedVersion)
- Funders
- National Institute on Aging (P01AG017242)
- National Cancer Institute (P30CA013330)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Physiology › Dietary Effects on Health
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Keywords
- accelerated aging, progeroid syndromes, DNA repair deficiency, Cockayne syndrome, lifespan extension, caloric restriction, genomic stress, transcriptional output, γH2AX foci, neuronal survival, motor function, survival response, endogenous DNA damage, healthspan
- MeSH terms
- DNA Excision Repair Protein ERCC-5, Aging, Animals, Brain, Diet, Reducing, DNA Damage, DNA Repair, DNA-Binding Proteins, Endonucleases, Female, Male, Nuclear Proteins, Transcription Factors, Neurodegenerative Diseases, Caloric Restriction, Genomic Instability, Mice, Transcriptome
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
