Summers, Scott A.

Expression of a Constitutively Active Akt Ser/Thr Kinase in 3T3-L1 Adipocytes Stimulates Glucose Uptake and Glucose Transporter 4 Translocation

Kohn, A. D., Summers, S. A., Birnbaum, M. J., & Roth, R. A. (1996) · Journal of Biological Chemistry

Metabolism, Diabetes, and CancerPI3K/AKT/mTOR signaling in cancer

Cited by 1,284

Inhibition of ceramide synthesis ameliorates glucocorticoid-, saturated-fat-, and obesity-induced insulin resistance

Holland, W. L., Brozinick, J. T., Wang, L.-P., Hawkins, E. D., Sargent, K. M., Liu, Y., Narra, K., Hoehn, K. L., Knotts, T. A., Siesky, A., et al. (2007) · Cell Metabolism

Sphingolipid Metabolism and SignalingAdipokines, Inflammation, and Metabolic Diseases

Cited by 1,232

Receptor-mediated activation of ceramidase activity initiates the pleiotropic actions of adiponectin

Holland, W. L., Miller, R. A., Wang, Z. V., Sun, K., Barth, B. M., Bui, H. H., Davis, K. E., Bikman, B. T., Halberg, N., Rutkowski, J. M., et al. (2011) · Nature Medicine

Sphingolipid Metabolism and SignalingAdipokines, Inflammation, and Metabolic Diseases

Cited by 892

Lipid-induced insulin resistance mediated by the proinflammatory receptor TLR4 requires saturated fatty acid–induced ceramide biosynthesis in mice

Holland, W. L., Bikman, B. T., Wang, L.-P., Yuguang, G., Sargent, K. M., Bulchand, S., Knotts, T. A., Shui, G., Clegg, D. J., Wenk, M. R., et al. (2011) · Journal of Clinical Investigation

Sphingolipid Metabolism and SignalingAdipokines, Inflammation, and Metabolic Diseases

Cited by 705

A role for ceramide, but not diacylglycerol, in the antagonism of insulin signal transduction by saturated fatty acids

Chavez, J. A., Knotts, T. A., Wang, L.-P., Li, G., Dobrowsky, R. T., Florant, G. L., & Summers, S. A. (2003) · Journal of Biological Chemistry

Sphingolipid Metabolism and SignalingMetabolism, Diabetes, and Cancer

Cited by 617

Characterizing the effects of saturated fatty acids on insulin signaling and ceramide and diacylglycerol accumulation in 3T3-L1 adipocytes and C2C12 myotubes

Chavez, J. A., & Summers, S. A. (2003) · Archives of Biochemistry and Biophysics

Metabolism, Diabetes, and CancerSphingolipid Metabolism and Signaling

Cited by 498

Regulation of Insulin-Stimulated Glucose Transporter GLUT4 Translocation and Akt Kinase Activity by Ceramide

Summers, S. A., Garza, L. A., Zhou, H., & Birnbaum, M. J. (1998) · Molecular and Cellular Biology

Sphingolipid Metabolism and SignalingMetabolism, Diabetes, and Cancer

Cited by 475

Regulation of Insulin Action by Ceramide

Stratford, S., Hoehn, K. L., Liu, F., & Summers, S. A. (2004) · Journal of Biological Chemistry

Sphingolipid Metabolism and SignalingMetabolism, Diabetes, and Cancer

Cited by 410

Thyroid hormone stimulates hepatic lipid catabolism via activation of autophagy

Sinha, R. A., You, S.-H., Zhou, J., Siddique, M. M., Bay, B.-H., Zhu, X., Privalsky, M. L., Cheng, S.-Y., Stevens, R. D., Summers, S. A., et al. (2012) · Journal of Clinical Investigation

Autophagy in Disease and TherapyThyroid Disorders and Treatments

Cited by 303

Extensive diversity in circadian regulation of plasma lipids and evidence for different circadian metabolic phenotypes in humans

Chua, E. C.-P., Shui, G., Lee, I. T.-G., Lau, P., Tan, L.-C., Yeo, S.-C., Lam, B. D., Bulchand, S., Summers, S. A., Puvanendran, K., et al. (2013) · Proceedings of the National Academy of Sciences

Circadian rhythm and melatoninMetabolomics and Mass Spectrometry Studies

Cited by 221

Ceramide dissociates 3′-phosphoinositide production from pleckstrin homology domain translocation

STRATFORD, S., DEWALD, D. B., & SUMMERS, S. A. (2001) · Biochemical Journal

Sphingolipid Metabolism and SignalingPI3K/AKT/mTOR signaling in cancer

Cited by 161

Sphingolipids and insulin resistance: the five Ws

Summers, S. A. (2010) · Current Opinion in Lipidology

Sphingolipid Metabolism and SignalingAdipokines, Inflammation, and Metabolic Diseases

Cited by 136

Autophagy Ablation in Adipocytes Induces Insulin Resistance and Reveals Roles for Lipid Peroxide and Nrf2 Signaling in Adipose-Liver Crosstalk

Cai, J., Pires, K. M., Ferhat, M., Chaurasia, B., Buffolo, M. A., Smalling, R., Sargsyan, A., Atkinson, D. L., Summers, S. A., Graham, T. E., et al. (2018) · Cell Reports

Autophagy in Disease and TherapyAdipose Tissue and Metabolism

Cited by 107

Ablation of AMP-Activated Protein Kinase α2 Activity Exacerbates Insulin Resistance Induced by High-Fat Feeding of Mice

Fujii, N., Ho, R. C., Manabe, Y., Jessen, N., Toyoda, T., Holland, W. L., Summers, S. A., Hirshman, M. F., & Goodyear, L. J. (2008) · Diabetes

Metabolism, Diabetes, and CancerDiet, Metabolism, and Disease

Cited by 107