Nakai, Hiroyuki

Successful transduction of liver in hemophilia by AAV-Factor IX and limitations imposed by the host immune response

Manno, C. S., Pierce, G. F., Arruda, V. R., Glader, B., Ragni, M., Rasko, J. J. E., Ozelo, M. C., Hoots, K., Blatt, P., Konkle, B., et al. (2006) · Nature Medicine

Virus-based gene therapy researchHemophilia Treatment and Research

Cited by 2,163

Robust systemic transduction with AAV9 vectors in mice: efficient global cardiac gene transfer superior to that of AAV8

Inagaki, K., Fuess, S., Storm, T. A., Gibson, G. A., Mctiernan, C. F., Kay, M. A., & Nakai, H. (2006) · Molecular Therapy

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 610

Extrachromosomal recombinant adeno-associated virus vector genomes are primarily responsible for stable liver transduction in vivo

Nakai, H., Yant, S. R., Storm, T. A., Fuess, S., Meuse, L., & Kay, M. A. (2001) · Journal of Virology

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 478

AAV serotype 2 vectors preferentially integrate into active genes in mice

Nakai, H., Montini, E., Fuess, S., Storm, T. A., Grompe, M., & Kay, M. A. (2003) · Nature Genetics

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 392

Characterization of Genome Integrity for Oversized Recombinant AAV Vector

Dong, B., Nakai, H., & Xiao, W. (2010) · Molecular Therapy

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 230

Recruitment of Single-Stranded Recombinant Adeno-Associated Virus Vector Genomes and Intermolecular Recombination Are Responsible for Stable Transduction of Liver In Vivo

Nakai, H., Storm, T. A., & Kay, M. A. (2000) · Journal of Virology

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 194

Large‐scale molecular characterization of adeno‐associated virus vector integration in mouse liver

Nakai, H., Wu, X., Fuess, S., Storm, T. A., Munroe, D., Montini, E., Burgess, S. M., Grompe, M., & Kay, M. A. (2005) · Journal of Virology

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 190

Liver Transduction with Recombinant Adeno-Associated Virus Is Primarily Restricted by Capsid Serotype Not Vector Genotype

Grimm, D., Pandey, K., Nakai, H., Storm, T. A., & Kay, M. A. (2006) · Journal of Virology

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 118

Adeno-associated Virus (AAV) Assembly-Activating Protein Is Not an Essential Requirement for Capsid Assembly of AAV Serotypes 4, 5, and 11

Earley, L. F., Powers, J. M., Adachi, K., Baumgart, J. T., Meyer, N. L., Xie, Q., Chapman, M. S., & Nakai, H. (2017) · Journal of Virology

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 108

Coexpression of factor VIII heavy and light chain adeno-associated viral vectors produces biologically active protein

Burton, M., Nakai, H., Colosi, P., Cunningham, J., Mitchell, R., & Couto, L. (1999) · Proceedings of the National Academy of Sciences

Hemophilia Treatment and ResearchVirus-based gene therapy research

Cited by 104

Helper‐independent and AAV‐ITR‐independent chromosomal integration of double‐stranded linear DNA vectors in mice

Nakai, H., Montini, E., Fuess, S., Storm, T. A., Meuse, L., Finegold, M., Grompe, M., & Kay, M. A. (2003) · Molecular Therapy

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 52

AAV vectors containing rDNA homology display increased chromosomal integration and transgene persistence

Wang, Z., Lisowski, L., Finegold, M. J., Nakai, H., Kay, M. A., & Grompe, M. (2012) · Molecular Therapy

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 44