McClanahan, Terrill

IL-23 drives a pathogenic T cell population that induces autoimmune inflammation

Langrish, C. L., Chen, Y., Blumenschein, W. M., Mattson, J., Basham, B., Sedgwick, J. D., McClanahan, T., Kastelein, R. A., & Cua, D. J. (2005) · The Journal of Experimental Medicine

Psoriasis: Treatment and PathogenesisT-cell and B-cell Immunology

Cited by 4,099

IFN-γ–related mRNA profile predicts clinical response to PD-1 blockade

Ayers, M., Lunceford, J., Nebozhyn, M., Murphy, E., Loboda, A., Kaufman, D. R., Albright, A., Cheng, J. D., Kang, S. P., Shankaran, V., et al. (2017) · Journal of Clinical Investigation

Cancer Immunotherapy and BiomarkersImmunotherapy and Immune Responses

Cited by 3,788

Pan-tumor genomic biomarkers for PD-1 checkpoint blockade–based immunotherapy

Cristescu, R., Mogg, R., Ayers, M., Albright, A., Murphy, E., Yearley, J., Sher, X., Liu, X. Q., Lu, H., Nebozhyn, M., et al. (2018) · Science

Cancer Immunotherapy and BiomarkersImmunotherapy and Immune Responses

Cited by 2,301

Development, cytokine profile and function of human interleukin 17-producing helper T cells

Wilson, N. J., Boniface, K., Chan, J. R., McKenzie, B. S., Blumenschein, W. M., Mattson, J. D., Basham, B., Smith, K., Chen, T., Morel, F., et al. (2007) · Nature Immunology

Psoriasis: Treatment and PathogenesisT-cell and B-cell Immunology

Cited by 2,035

Safety and clinical activity of pembrolizumab for treatment of recurrent or metastatic squamous cell carcinoma of the head and neck (KEYNOTE-012): an open-label, multicentre, phase 1b trial

Seiwert, T. Y., Burtness, B., Mehra, R., Weiss, J., Berger, R., Eder, J. P., Heath, K., McClanahan, T., Lunceford, J., Gause, C., et al. (2016) · The Lancet Oncology

Cancer Immunotherapy and BiomarkersHead and Neck Cancer Studies

Cited by 1,745

Divergent Pro- and Antiinflammatory Roles for IL-23 and IL-12 in Joint Autoimmune Inflammation

Murphy, C. A., Langrish, C. L., Chen, Y., Blumenschein, W., McClanahan, T., Kastelein, R. A., Sedgwick, J. D., & Cua, D. J. (2003) · The Journal of Experimental Medicine

Psoriasis: Treatment and PathogenesisRheumatoid Arthritis Research and Therapies

Cited by 1,669

TGF-β and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain TH-17 cell–mediated pathology

McGeachy, M. J., Bak-Jensen, K. S., Chen, Y., Tato, C. M., Blumenschein, W., McClanahan, T., & Cua, D. J. (2007) · Nature Immunology

Psoriasis: Treatment and PathogenesisT-cell and B-cell Immunology

Cited by 1,520

The interleukin 23 receptor is essential for the terminal differentiation of interleukin 17-producing effector T helper cells in vivo

McGeachy, M. J., Chen, Y., Tato, C. M., Laurence, A., Joyce-Shaikh, B., Blumenschein, W. M., McClanahan, T. K., O'Shea, J. J., & Cua, D. J. (2009) · Nature Immunology

Psoriasis: Treatment and PathogenesisT-cell and B-cell Immunology

Cited by 1,074

IL-23 promotes tumour incidence and growth

Langowski, J. L., Zhang, X., Wu, L., Mattson, J. D., Chen, T., Smith, K., Basham, B., McClanahan, T., Kastelein, R. A., & Oft, M. (2006) · Nature

Immune cells in cancerCytokine Signaling Pathways and Interactions

Cited by 1,018

Multiplexed quantification of proteins and transcripts in single cells

Peterson, V. M., Zhang, K. X., Kumar, N., Wong, J., Li, L., Wilson, D. C., Moore, R., McClanahan, T. K., Sadekova, S., & Klappenbach, J. A. (2017) · Nature Biotechnology

Single-cell and spatial transcriptomicsInnovative Microfluidic and Catalytic Techniques Innovation

Cited by 832

Interleukin-23-Independent IL-17 Production Regulates Intestinal Epithelial Permeability

Lee, J. S., Tato, C. M., Joyce-Shaikh, B., Gulen, M. F., Cayatte, C., Chen, Y., Blumenschein, W. M., Judo, M., Ayanoglu, G., McClanahan, T. K., et al. (2015) · Immunity

Psoriasis: Treatment and PathogenesisInflammatory Bowel Disease

Cited by 760

PD-L2 Expression in Human Tumors: Relevance to Anti-PD-1 Therapy in Cancer

Yearley, J. H., Gibson, C., Yu, N., Moon, C., Murphy, E., Juco, J., Lunceford, J., Cheng, J., Chow, L. Q. M., Seiwert, T. Y., et al. (2017) · Clinical Cancer Research

Cancer Immunotherapy and BiomarkersImmunotherapy and Immune Responses

Cited by 594

Circulating and gut-resident human Th17 cells express CD161 and promote intestinal inflammation

Kleinschek, M. A., Boniface, K., Sadekova, S., Grein, J., Murphy, E. E., Turner, S. P., Raskin, L., Desai, B., Faubion, W. A., de Waal Malefyt, R., et al. (2009) · Journal of Experimental Medicine

Psoriasis: Treatment and PathogenesisInflammatory Bowel Disease

Cited by 460

Monoclonal Anti–Interleukin 23 Reverses Active Colitis in a T Cell–Mediated Model in Mice

Elson, C. O., Cong, Y., Weaver, C. T., Schoeb, T. R., McClanahan, T. K., Fick, R. B., & Kastelein, R. A. (2007) · Gastroenterology

Inflammatory Bowel DiseasePsoriasis: Treatment and Pathogenesis

Cited by 453

IL-10 Elicits IFNγ-Dependent Tumor Immune Surveillance

Mumm, J. B., Emmerich, J., Zhang, X., Chan, I., Wu, L., Mauze, S., Blaisdell, S., Basham, B., Dai, J., Grein, J., et al. (2011) · Cancer Cell

Cancer Immunotherapy and BiomarkersImmunotherapy and Immune Responses

Cited by 418

IL-25 regulates Th17 function in autoimmune inflammation

Kleinschek, M. A., Owyang, A. M., Joyce-Shaikh, B., Langrish, C. L., Chen, Y., Gorman, D. M., Blumenschein, W. M., McClanahan, T., Brombacher, F., Hurst, S. D., et al. (2007) · The Journal of Experimental Medicine

Psoriasis: Treatment and PathogenesisT-cell and B-cell Immunology

Cited by 396

Interleukin 25 regulates type 2 cytokine-dependent immunity and limits chronic inflammation in the gastrointestinal tract

Owyang, A. M., Zaph, C., Wilson, E. H., Guild, K. J., McClanahan, T., Miller, H. R. P., Cua, D. J., Goldschmidt, M., Hunter, C. A., Kastelein, R. A., et al. (2006) · The Journal of Experimental Medicine

IL-33, ST2, and ILC PathwaysParasites and Host Interactions

Cited by 379

LAG3+ Regulatory T Cells Restrain Interleukin-23-Producing CX3CR1+ Gut-Resident Macrophages during Group 3 Innate Lymphoid Cell-Driven Colitis

Bauché, D., Joyce-Shaikh, B., Jain, R., Grein, J., Ku, K. S., Blumenschein, W. M., Ganal-Vonarburg, S. C., Wilson, D. C., McClanahan, T. K., Malefyt, R. D. W., et al. (2018) · Immunity

IL-33, ST2, and ILC PathwaysT-cell and B-cell Immunology

Cited by 202

Interleukin-23-Induced Transcription Factor Blimp-1 Promotes Pathogenicity of T Helper 17 Cells

Jain, R., Chen, Y., Kanno, Y., Joyce-Shaikh, B., Vahedi, G., Hirahara, K., Blumenschein, W. M., Sukumar, S., Haines, C. J., Sadekova, S., et al. (2016) · Immunity

Psoriasis: Treatment and PathogenesisT-cell and B-cell Immunology

Cited by 167