Sitkovsky, Michail V.

Immunological mechanisms of the antitumor effects of supplemental oxygenation

Hatfield, S. M., Kjaergaard, J., Lukashev, D., Schreiber, T. H., Belikoff, B., Abbott, R., Sethumadhavan, S., Philbrook, P., Ko, K., Cannici, R., et al. (2015) · Science Translational Medicine

Adenosine and Purinergic SignalingCancer Immunotherapy and Biomarkers

Cited by 600

Role of A2a Extracellular Adenosine Receptor-Mediated Signaling in Adenosine-Mediated Inhibition of T-Cell Activation and Expansion

Huang, S., Apasov, S., Koshiba, M., & Sitkovsky, M. (1997) · Blood

Adenosine and Purinergic SignalingBiochemical and Molecular Research

Cited by 531

Regulation of immune cells by local-tissue oxygen tension: HIF1α and adenosine receptors

Sitkovsky, M., & Lukashev, D. (2005) · Nature Reviews Immunology

Cancer, Hypoxia, and MetabolismAdenosine and Purinergic Signaling

Cited by 518

Differential Effects of Physiologically Relevant Hypoxic Conditions on T Lymphocyte Development and Effector Functions

Caldwell, C. C., Kojima, H., Lukashev, D., Armstrong, J., Farber, M., Apasov, S. G., & Sitkovsky, M. V. (2001) · The Journal of Immunology

T-cell and B-cell ImmunologyCancer, Hypoxia, and Metabolism

Cited by 420

Hypoxia-Adenosinergic Immunosuppression: Tumor Protection by T Regulatory Cells and Cancerous Tissue Hypoxia

Sitkovsky, M. V., Kjaergaard, J., Lukashev, D., & Ohta, A. (2008) · Clinical Cancer Research

Adenosine and Purinergic SignalingCancer Immunotherapy and Biomarkers

Cited by 253

Abnormal B lymphocyte development and autoimmunity in hypoxia-inducible factor 1α-deficient chimeric mice

Kojima, H., Gu, H., Nomura, S., Caldwell, C. C., Kobata, T., Carmeliet, P., Semenza, G. L., & Sitkovsky, M. V. (2002) · Proceedings of the National Academy of Sciences

T-cell and B-cell ImmunologySystemic Lupus Erythematosus Research

Cited by 224

Hostile, Hypoxia–A2-Adenosinergic Tumor Biology as the Next Barrier to Overcome for Tumor Immunologists

Sitkovsky, M. V., Hatfield, S., Abbott, R., Belikoff, B., Lukashev, D., & Ohta, A. (2014) · Cancer Immunology Research

Adenosine and Purinergic SignalingCancer Immunotherapy and Biomarkers

Cited by 215

Systemic oxygenation weakens the hypoxia and hypoxia inducible factor 1α-dependent and extracellular adenosine-mediated tumor protection

Hatfield, S. M., Kjaergaard, J., Lukashev, D., Belikoff, B., Schreiber, T. H., Sethumadhavan, S., Abbott, R., Philbrook, P., Thayer, M., Shujia, D., et al. (2014) · Journal of Molecular Medicine

Cancer, Hypoxia, and MetabolismAdenosine and Purinergic Signaling

Cited by 211

Cutting Edge: Hypoxia-Inducible Factor 1α and Its Activation-Inducible Short Isoform I.1 Negatively Regulate Functions of CD4+ and CD8+ T Lymphocytes

Lukashev, D., Klebanov, B., Kojima, H., Grinberg, A., Ohta, A., Berenfeld, L., Wenger, R. H., Ohta, A., & Sitkovsky, M. (2006) · The Journal of Immunology

Cancer, Hypoxia, and MetabolismT-cell and B-cell Immunology

Cited by 208

Targeted Deletion of HIF-1α Gene in T Cells Prevents their Inhibition in Hypoxic Inflamed Tissues and Improves Septic Mice Survival

Thiel, M., Caldwell, C. C., Kreth, S., Kuboki, S., Chen, P., Smith, P., Ohta, A., Lentsch, A. B., Lukashev, D., & Sitkovsky, M. V. (2007) · PLoS ONE

Cancer, Hypoxia, and MetabolismSepsis Diagnosis and Treatment

Cited by 175

A2A Adenosine Receptor Gene Deletion or Synthetic A2A Antagonist Liberate Tumor-Reactive CD8+ T Cells from Tumor-Induced Immunosuppression

Kjaergaard, J., Hatfield, S., Jones, G., Ohta, A., & Sitkovsky, M. (2018) · The Journal of Immunology

Adenosine and Purinergic SignalingCancer Immunotherapy and Biomarkers

Cited by 132

Hypoxia and hypoxia-inducible factor (HIF) downregulate antigen-presenting MHC class I molecules limiting tumor cell recognition by T cells

Sethumadhavan, S., Silva, M., Philbrook, P., Nguyen, T., Hatfield, S. M., Ohta, A., & Sitkovsky, M. V. (2017) · PLOS ONE

Immunotherapy and Immune ResponsesCancer, Hypoxia, and Metabolism

Cited by 119

Antihypoxic oxygenation agents with respiratory hyperoxia to improve cancer immunotherapy

Hatfield, S. M., & Sitkovsky, M. V. (2020) · Journal of Clinical Investigation

Cancer, Hypoxia, and MetabolismAdenosine and Purinergic Signaling

Cited by 73

Oxygenation to improve cancer vaccines, adoptive cell transfer and blockade of immunological negative regulators

Hatfield, S. M., & Sitkovsky, M. (2015) · OncoImmunology

Adenosine and Purinergic SignalingCancer Immunotherapy and Biomarkers

Cited by 31

Preferential expression of the novel alternative isoform I.3 of hypoxia-inducible factor 1α in activated human T lymphocytes

Lukashev, D., & Sitkovsky, M. (2008) · Human Immunology

Cancer, Hypoxia, and MetabolismT-cell and B-cell Immunology

Cited by 25