Oxygenation to improve cancer vaccines, adoptive cell transfer and blockade of immunological negative regulators
Open accessAbstract
Oxygenation of tumors weakens the tumor-protecting immunosuppressive signaling by A2A adenosine receptors in hypoxic and extracellular adenosine-rich microenvironments. This, in turn, unleashes the otherwise inhibited tumor-reactive T and natural killer (NK) cells. Oxygenation of tumors thus emerges as a novel checkpoint inhibitor of potential therapeutic value, but only in combination with cancer immunotherapies.
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Direct elimination of TME hypoxia can improve cancer immunotherapy in mice.
“Subsequently, it was shown that direct elimination of TME hypoxia can improve cancer immunotherapy in mice (27, 38, 39).”
From Targeting HIF-1α abrogates PD-L1–mediated immune evasion in tumor microenvironment but promotes tolerance in normal tissues (2022) · cites this paper as [39]
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- Authors
- Hatfield, S. M., & Sitkovsky, M.
- Affiliations
- Northeastern University (US)
- Corresponding author
- Sitkovsky, Michail
- Venue
- OncoImmunology
- Publisher
- Informa UK Limited
- Published
- 2015-06
- Volume
- 4
- Issue
- 12
- Pages
- e1052934
- ISSN
- 2162-4011 (ISSN-L)
- 2162-402X
- PMC
- PMC4635883
- OpenAlex
- W2136374665
- Cited by
- 31
- References
- 9
- Citations by year
- 2026: 3 · 2025: 3 · 2023: 1 · 2022: 6 · 2021: 6 · 2020: 2 · 2019: 5 · 2018: 4 · 2017: 1
- FWCI
- 1.40
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by-nc
- Locations
- OncoImmunology (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
- Funders
- National Cancer Institute (R01CA111985)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Adenosine and Purinergic Signaling
- Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Keywords
- tumor oxygenation, adenosine A2A receptor, tumor hypoxia, extracellular adenosine, tumor microenvironment, immunosuppression, cancer vaccines, adoptive cell transfer, immune checkpoint blockade, T cells, natural killer cells, cancer immunotherapy
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