Ottmann, Christian

Modulators of Protein–Protein Interactions

Milroy, L.-G., Grossmann, T. N., Hennig, S., Brunsveld, L., & Ottmann, C. (2014) · Chemical Reviews

14-3-3 protein interactionsChemical Synthesis and Analysis

Cited by 497

Structure of a 14-3-3 Coordinated Hexamer of the Plant Plasma Membrane H+-ATPase by Combining X-Ray Crystallography and Electron Cryomicroscopy

Ottmann, C., Marco, S., Jaspert, N., Marcon, C., Schauer, N., Weyand, M., Vandermeeren, C., Duby, G., Boutry, M., Wittinghofer, A., et al. (2007) · Molecular Cell

14-3-3 protein interactionsATP Synthase and ATPases Research

Cited by 255

Constrained Peptides with Target‐Adapted Cross‐Links as Inhibitors of a Pathogenic Protein–Protein Interaction

Glas, A., Bier, D., Hahne, G., Rademacher, C., Ottmann, C., & Grossmann, T. N. (2014) · Angewandte Chemie International Edition

Chemical Synthesis and AnalysisBiochemical and Structural Characterization

Cited by 145

A Semisynthetic Fusicoccane Stabilizes a Protein-Protein Interaction and Enhances the Expression of K+ Channels at the Cell Surface

Anders, C., Higuchi, Y., Koschinsky, K., Bartel, M., Schumacher, B., Thiel, P., Nitta, H., Preisig-Müller, R., Schlichthörl, G., Renigunta, V., et al. (2013) · Chemistry & Biology

14-3-3 protein interactionsIon channel regulation and function

Cited by 106

A Structural Rationale for Selective Stabilization of Anti-tumor Interactions of 14-3-3 proteins by Cotylenin A

Ottmann, C., Weyand, M., Sassa, T., Inoue, T., Kato, N., Wittinghofer, A., & Oecking, C. (2009) · Journal of Molecular Biology

14-3-3 protein interactionsProtein Interaction Studies and Fluorescence Analysis

Cited by 94

Stabilization and Inhibition of Protein–Protein Interactions: The 14-3-3 Case Study

Milroy, L.-G., Brunsveld, L., & Ottmann, C. (2013) · ACS Chemical Biology

14-3-3 protein interactionsChemical Synthesis and Analysis

Cited by 88

Synthesis and Crystal Structure of a Phosphorylated Estrogen Receptor Ligand Binding Domain

Möcklinghoff, S., Rose, R., Carraz, M., Visser, A., Ottmann, C., & Brunsveld, L. (2010) · ChemBioChem

Chemical Synthesis and AnalysisEstrogen and related hormone effects

Cited by 87

Structure-based evolution of a promiscuous inhibitor to a selective stabilizer of protein–protein interactions

Sijbesma, E., Visser, E., Plitzko, K., Thiel, P., Milroy, L.-G., Kaiser, M., Brunsveld, L., & Ottmann, C. (2020) · Nature Communications

14-3-3 protein interactionsComputational Drug Discovery Methods

Cited by 72

Proline primed helix length as a modulator of the nuclear receptor-coactivator interaction

Fuchs, S., Nguyen, H. D., Phan, T. T. P., Burton, M. F., Nieto, L., de Vries-van Leeuwen, I. J., Schmidt, A., Goodarzifard, M., Agten, S. M., Rose, R., et al. (2013) · Journal of the American Chemical Society

Estrogen and related hormone effectsProtein Structure and Dynamics

Cited by 43