Redinbo, Matthew R.

Alleviating Cancer Drug Toxicity by Inhibiting a Bacterial Enzyme

Wallace, B. D., Wang, H., Lane, K. T., Scott, J. E., Orans, J., Koo, J. S., Venkatesh, M., Jobin, C., Yeh, L.-A., Mani, S., et al. (2010) · Science

Pharmacogenetics and Drug MetabolismCancer therapeutics and mechanisms

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Symbiotic bacterial metabolites regulate gastrointestinal barrier function via the xenobiotic sensor PXR and Toll-like receptor 4

Venkatesh, M., Mukherjee, S., Wang, H., Li, H., Sun, K., Benechet, A. P., Qiu, Z., Maher, L., Redinbo, M. R., Phillips, R. S., et al. (2014) · Immunity

Gut microbiota and healthGastrointestinal motility and disorders

Cited by 1,066

The role of the microbiome in cancer development and therapy

Bhatt, A. P., Redinbo, M. R., & Bultman, S. J. (2017) · CA A Cancer Journal for Clinicians

Gut microbiota and healthBacterial Cancer Therapy

Cited by 653

Gut microbial β-glucuronidases reactivate estrogens as components of the estrobolome that reactivate estrogens

Ervin, S. M., Li, H., Lim, L., Roberts, L. R., Liang, X., Mani, S., & Redinbo, M. R. (2019) · Journal of Biological Chemistry

Gut microbiota and healthEstrogen and related hormone effects

Cited by 397

An atlas of β-glucuronidases in the human intestinal microbiome

Pollet, R. M., D'Agostino, E. H., Walton, W. G., Xu, Y., Little, M. S., Biernat, K. A., Pellock, S. J., Patterson, L. M., Creekmore, B. C., Isenberg, H. N., et al. (2017) · Structure

Gut microbiota and healthPharmacogenetics and Drug Metabolism

Cited by 289

Structure and Inhibition of Microbiome β-Glucuronidases Essential to the Alleviation of Cancer Drug Toxicity

Wallace, B. D., Roberts, A. B., Pollet, R. M., Ingle, J. D., Biernat, K. A., Pellock, S. J., Venkatesh, M. K., Guthrie, L., O’Neal, S. K., Robinson, S. J., et al. (2015) · Chemistry & Biology

Enzyme Structure and FunctionPharmacogenetics and Drug Metabolism

Cited by 285

Pharmacologic Targeting of Bacterial β-Glucuronidase Alleviates Nonsteroidal Anti-Inflammatory Drug-Induced Enteropathy in Mice

LoGuidice, A., Wallace, B. D., Bendel, L., Redinbo, M. R., & Boelsterli, U. A. (2012) · The Journal of Pharmacology and Experimental Therapeutics

Inflammatory mediators and NSAID effectsPharmacogenetics and Drug Metabolism

Cited by 197

Bile salt hydrolases shape the bile acid landscape and restrict Clostridioides difficile growth in the murine gut

Foley, M. H., Walker, M. E., Stewart, A. K., O’Flaherty, S., Gentry, E. C., Patel, S., Beaty, V. V., Allen, G., Pan, M., Simpson, J. B., et al. (2023) · Nature Microbiology

Clostridium difficile and Clostridium perfringens researchGut microbiota and health

Cited by 181

Bacterial β-glucuronidase inhibition protects mice against enteropathy induced by indomethacin, ketoprofen or diclofenac: mode of action and pharmacokinetics

Saitta, K. S., Zhang, C., Lee, K. K., Fujimoto, K., Redinbo, M. R., & Boelsterli, U. A. (2014) · Xenobiotica

Inflammatory mediators and NSAID effectsPharmacogenetics and Drug Metabolism

Cited by 165

Molecular Insights into Microbial β-Glucuronidase Inhibition to Abrogate CPT-11 Toxicity

Roberts, A. B., Wallace, B. D., Venkatesh, M. K., Mani, S., & Redinbo, M. R. (2013) · Molecular Pharmacology

Pharmacogenetics and Drug MetabolismDrug Transport and Resistance Mechanisms

Cited by 140

Gut microbial β-glucuronidases regulate host luminal proteases and are depleted in irritable bowel syndrome

Edwinson, A. L., Yang, L., Peters, S., Hanning, N., Jeraldo, P., Jagtap, P., Simpson, J. B., Yang, T.-Y., Kumar, P., Mehta, S., et al. (2022) · Nature Microbiology

Gut microbiota and healthGastrointestinal motility and disorders

Cited by 105

Understanding and Modulating Mammalian-Microbial Communication for Improved Human Health

Mani, S., Boelsterli, U. A., & Redinbo, M. R. (2014) · Annual Review of Pharmacology and Toxicology

Gut microbiota and healthPharmacogenetics and Drug Metabolism

Cited by 48

Metagenomics Combined with Activity-Based Proteomics Point to Gut Bacterial Enzymes that Reactivate Mycophenolate

Simpson, J. B., Sekela, J. J., Graboski, A. L., Borlandelli, V. B., Barker, N. K., Sorgen, A. A., Bivins, M. M., Mordant, A. L., Johnson, R. L., Bhatt, A. P., et al. (2022) · Gut Microbes

Pharmacogenetics and Drug MetabolismGut microbiota and health

Cited by 45

A High Throughput Assay for Discovery of Bacterial β-Glucuronidase Inhibitors

Ahmad, S., Hughes, M. A., Lane, K. T., Redinbo, M. R., Yeh, L.-A., & Scott, J. E. (2011) · Current Chemical Genomics

Pharmacogenetics and Drug MetabolismCancer therapeutics and mechanisms

Cited by 29