An atlas of β-glucuronidases in the human intestinal microbiome

Pollet, Rebecca M.; D'Agostino, Emma H.; Walton, William G.; Xu, Yongmei; Little, Michael S.; Biernat, Kristen A.; Pellock, Samuel J.; Patterson, Loraine M.; Creekmore, Benjamin C.; Isenberg, Hanna N.; Bahethi, Rohini R.; Bhatt, Aadra P.; Liu, Jian; Gharaibeh, Raad Z.; Redinbo, Matthew R.

doi:10.1016/j.str.2017.05.003

Cited by 292Gut microbiota and healthPharmacogenetics and Drug MetabolismAntibiotic Resistance in Bacteria

An atlas of β-glucuronidases in the human intestinal microbiome

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Pollet, Rebecca M., D'Agostino, Emma H., Walton, William G., Xu, Yongmei, Little, Michael S., Biernat, Kristen A., Pellock, Samuel J., Patterson, Loraine M. +7 more·2017·Structure

DOI 10.1016/j.str.2017.05.003PMC PMC5533298

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Abstract

Microbiome-encoded β-glucuronidase (GUS) enzymes play important roles in human health by metabolizing drugs in the gastrointestinal (GI) tract. The numbers, types, and diversity of these proteins in the human GI microbiome, however, remain undefined. We present an atlas of GUS enzymes comprehensive for the Human Microbiome Project GI database. We identify 3,013 total and 279 unique microbiome-encoded GUS proteins clustered into six unique structural categories. We assign their taxonomy, assess cellular localization, reveal the inter-individual variability within the 139 individuals sampled, and discover 112 novel microbial GUS enzymes. A representative in vitro panel of the most common GUS proteins by read abundances highlights structural and functional variabilities within the family, including their differential processing of smaller glucuronides and larger carbohydrates. These data provide a sequencing-to-molecular roadmap for examining microbiome-encoded enzymes essential to human health.

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A recent analysis of the Human Microbiome Project gastrointestinal database revealed a total of 3013 microbiome-encoded beta-glucuronidases, which clustered into structural categories with differing functional capacities for various glucuronide substrates.
“A recent analysis of the Human Microbiome Project gastrointestinal database is instructive on the complexity of this metabolic function, revealing a total of 3013 microbiome-encoded b-glucuronidases, which clustered into structural categories with differing functional capacities for various glucuronide substrates (Pollet et al., 2017).”
From Gut reactions: Breaking down xenobiotic–microbiome interactions (2019) · cites this paper as Pollet et al., 2017
Microbial enzymes such as b-glucuronidases can differ in substrate selectivity and activity depending on the bacteria from which they arise.
“Microbial enzymes, such as b-glucuronidases, can differ in substrate selectivity and activity depending on the bacteria from which they arise (Pollet et al., 2017).”
From Gut reactions: Breaking down xenobiotic–microbiome interactions (2019) · cites this paper as Pollet et al., 2017

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Mouse Gut Microbiome-Encoded β-Glucuronidases Identified using MAPS, Metagenome Analysis by Protein Structure
Creekmore, B. C. (2019) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/6wg7-gp86
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Three structurally and functionally distinct β-glucuronidases from the human gut microbe Bacteroides uniformis
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Mouse Gut Microbiome-Encoded β-Glucuronidases Identified Using Metagenome Analysis Guided by Protein Structure
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THE STRUCTURE, FUNCTION, AND INHIBITION OF GUT BACTERIAL β-GLUCURONIDASES
Pellock, S. J. (2022) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/r82v-r124

Authors: Pollet, R. M., D'Agostino, E. H., Walton, W. G., Xu, Y., Little, M. S., Biernat, K. A., Pellock, S. J., Patterson, L. M., Creekmore, B. C., Isenberg, H. N., Bahethi, R. R., Bhatt, A. P., Liu, J., Gharaibeh, R. Z., & Redinbo, M. R.
Affiliations: University of North Carolina at Chapel Hill (US)
University of North Carolina at Charlotte (US)
Corresponding author: Redinbo, Matthew R.
ORCID: Pollet, Rebecca M.
Walton, William G.
Xu, Yongmei
Pellock, Samuel J.
Patterson, Loraine M.
Creekmore, Benjamin C.
Bahethi, Rohini R.
Bhatt, Aadra P.
Liu, Jian
Gharaibeh, Raad Z.
Redinbo, Matthew R.
Venue: Structure
Publisher: Elsevier BV
Published: 2017-07
Volume: 25
Issue: 7
Pages: 967-977.e5
ISSN: 0969-2126 (ISSN-L)
DOI: 10.1016/j.str.2017.05.003
PMC: PMC5533298
OpenAlex: W2620740368
Cited by: 289
References: 55
Citations by year: 2026: 40 · 2025: 43 · 2024: 47 · 2023: 33 · 2022: 43 · 2021: 26 · 2020: 22 · 2019: 20 · 2018: 13 · 2017: 1
FWCI: 6.26
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 369 d)
Locations: Structure (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: NIH (CA098468, CA207416)
Eshelman Institute for Innovation (T32 DK007737, GM102137, HL094463)
Tom and Elizabeth Long Research Award
J. Thurman Frieze Summer Research Scholarship
University of North Carolina (5T32GM008570-20)
NSF Graduate Research Fellowships
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Antibiotic Resistance in Bacteria
Keywords: beta-glucuronidase, drug metabolism, glucuronide metabolism, enzyme diversity, enzyme discovery, interindividual variability, subcellular localization
MeSH terms: Gastrointestinal Microbiome, Bacterial Proteins, Glucuronidase, Humans

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An atlas of β-glucuronidases in the human intestinal microbiome

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