Birsoy, Kıvanç

Functional genomics reveal that the serine synthesis pathway is essential in breast cancer

Possemato, R., Marks, K. M., Shaul, Y. D., Pacold, M. E., Kim, D., Birsoy, K., Sethumadhavan, S., Woo, H.-K., Jang, H. G., Jha, A. K., et al. (2011) · Nature

Cancer, Hypoxia, and MetabolismAmino Acid Enzymes and Metabolism

Cited by 1,683

Identification and characterization of essential genes in the human genome

Wang, T., Birsoy, K., Hughes, N. W., Krupczak, K. M., Post, Y., Wei, J. J., Lander, E. S., & Sabatini, D. M. (2015) · Science

CRISPR and Genetic EngineeringChromatin Remodeling and Cancer

Cited by 1,617

An essential role of the mitochondrial electron transport chain in cell proliferation is to enable aspartate synthesis

Birsoy, K., Wang, T., Chen, W. W., Freinkman, E., Abu-Remaileh, M., & Sabatini, D. M. (2015) · Cell

Cancer, Hypoxia, and MetabolismMitochondrial Function and Pathology

Cited by 1,388

NFS1 undergoes positive selection in lung tumours and protects cells from ferroptosis

Alvarez, S. W., Sviderskiy, V. O., Terzi, E. M., Papagiannakopoulos, T., Moreira, A. L., Adams, S., Sabatini, D. M., Birsoy, K., & Possemato, R. (2017) · Nature

Ferroptosis and cancer prognosisCancer, Hypoxia, and Metabolism

Cited by 787

Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides

Birsoy, K., Possemato, R., Lorbeer, F. K., Bayraktar, E. C., Thiru, P., Yucel, B., Wang, T., Chen, W. W., Clish, C. B., & Sabatini, D. M. (2014) · Nature

Cancer, Hypoxia, and MetabolismMetabolism, Diabetes, and Cancer

Cited by 710

A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate

Pacold, M. E., Brimacombe, K. R., Chan, S. H., Rohde, J. M., Lewis, C. A., Swier, L. J. Y. M., Possemato, R., Chen, W. W., Sullivan, L. B., Fiske, B. P., et al. (2016) · Nature Chemical Biology

Cancer, Hypoxia, and MetabolismBiochemical and Molecular Research

Cited by 553

Absolute quantification of matrix metabolites reveals the dynamics of mitochondrial metabolism

Chen, W. W., Freinkman, E., Wang, T., Birsoy, K., & Sabatini, D. M. (2016) · Cell

Mitochondrial Function and PathologyMetabolomics and Mass Spectrometry Studies

Cited by 500

Aspartate is a limiting metabolite for cancer cell proliferation under hypoxia and in tumours

Garcia-Bermudez, J., Baudrier, L., La, K., Zhu, X. G., Fidelin, J., Sviderskiy, V. O., Papagiannakopoulos, T., Molina, H., Snuderl, M., Lewis, C. A., et al. (2018) · Nature Cell Biology

Cancer, Hypoxia, and MetabolismAmino Acid Enzymes and Metabolism

Cited by 442

Antidiabetic Effects of IGFBP2, a Leptin-Regulated Gene

Hedbacker, K., Birsoy, K., Wysocki, R. W., Asilmaz, E., Ahima, R. S., Farooqi, I. S., & Friedman, J. M. (2010) · Cell Metabolism

Regulation of Appetite and ObesityAdipokines, Inflammation, and Metabolic Diseases

Cited by 280

Maintaining Iron Homeostasis Is the Key Role of Lysosomal Acidity for Cell Proliferation

Weber, R. A., Yen, F. S., Nicholson, S. P. V., Alwaseem, H., Bayraktar, E. C., Alam, M., Timson, R. C., La, K., Abu-Remaileh, M., Molina, H., et al. (2020) · Molecular Cell

Autophagy in Disease and TherapyIron Metabolism and Disorders

Cited by 236

Functional genomics in vivo reveal metabolic dependencies of pancreatic cancer cells

Zhu, X. G., Chudnovskiy, A., Baudrier, L., Prizer, B., Liu, Y., Ostendorf, B. N., Yamaguchi, N., Arab, A., Tavora, B., Timson, R., et al. (2021) · Cell Metabolism

Pancreatic and Hepatic Oncology ResearchCancer, Hypoxia, and Metabolism

Cited by 130

Metabolic gene function discovery platform GeneMAP identifies SLC25A48 as necessary for mitochondrial choline import

Khan, A., Unlu, G., Lin, P., Liu, Y., Kilic, E., Kenny, T. C., Birsoy, K., & Gamazon, E. R. (2024) · Nature Genetics

Genetic Associations and EpidemiologyMetabolism and Genetic Disorders

Cited by 29