Functional genomics in vivo reveal metabolic dependencies of pancreatic cancer cells

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Autophagy Contributes to Metabolic Reprogramming and Therapeutic Resistance in Pancreatic Tumors

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Mitochondria and CancerPreprint

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Heme metabolism in nonerythroid cells

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Cancer metabolism within tumor microenvironments

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Porphyrin overdrive rewires cancer cell metabolism

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Challenges in Studying Stem Cell Metabolism

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The prognostic value of an autophagy-related lncRNA signature in hepatocellular carcinoma

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ENT1 blockade by CNX-774 overcomes resistance to DHODH inhibition in pancreatic cancer

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Methods and applications of in vivo CRISPR screening

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Simvastatin overcomes the pPCK1‐pLDHA‐SPRINGlac axis‐mediated ferroptosis and chemo‐immunotherapy resistance in AKT‐hyperactivated intrahepatic cholangiocarcinoma

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Metabolic plasticity in pancreatic cancer: The mitochondrial connection

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Beyond glucose and Warburg: finding the sweet spot in cancer metabolism models

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Genome-wide CRISPR screens define determinants of epithelial-mesenchymal transition mediated immune evasion by pancreatic cancer cells

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Metabolic landscape of disseminated cancer dormancy

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An Analysis of the Multifaceted Roles of Heme in the Pathogenesis of Cancer and Related Diseases

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SREBP-Dependent Regulation of Lipid Homeostasis Is Required for Progression and Growth of Pancreatic Ductal Adenocarcinoma

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ISL2 is a putative tumor suppressor whose epigenetic silencing reprograms the metabolism of pancreatic cancer

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TRIM65/NF2/YAP1 Signaling Coordinately Orchestrates Metabolic and Immune Advantages in Hepatocellular Carcinoma

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The Role of Stroma in Cancer MetabolismPreprint

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What’s on the menu?: metabolic constraints in the pancreatic tumor microenvironment

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De novo pyrimidine biosynthesis inhibition synergizes with BCL-XL targeting in pancreatic cancer

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Prkci Regulates Autophagy and Pancreatic Tumorigenesis in Mice

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Pancreatic ductal adenocarcinoma: Emerging therapeutic strategies

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Inhibition of Heme Export and/or Heme Synthesis Potentiates Metformin Anti-Proliferative Effect on Cancer Cell Lines

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A Targetable Secreted Neural Protein Drives Pancreatic Cancer Metastatic Colonization and HIF1α Nuclear Retention

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A novel gene signature unveils three distinct immune-metabolic rewiring patterns conserved across diverse tumor types and associated with outcomes

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Uncovering Porphyrin Accumulation in the Tumor Microenvironment

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Lessons to Learn for Adequate Targeted Therapy Development in Metastatic Colorectal Cancer Patients

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Autophagy as a critical driver of metabolic adaptation, therapeutic resistance, and immune evasion of cancer

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Unearthing FLVCR1a: tracing the path to a vital cellular transporter

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De Novo Purine Metabolism is a Metabolic Vulnerability of Cancers with Low p16 Expression

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Heme promotes venetoclax resistance in multiple myeloma through MEK-ERK signaling and purine biosynthesis

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Impaired mitochondrial metabolism is a critical cancer vulnerability for MYC inhibitors

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Disruption of proteome by an oncogenic fusion kinase alters metabolism in fibrolamellar hepatocellular carcinoma

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Metabolic plasticity in pancreatic ductal adenocarcinoma progression and response to treatment

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Autophagy modulation in cancer

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Recreating metabolic interactions of the tumour microenvironment

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Genome-aware annotation of CRISPR guides validates targets in variant cell lines and enhances discovery in screens

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Inhibition of MBTPS1 enhances antitumor immunity and potentiates anti-PD-1 immunotherapy

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Cell of Origin of Pancreatic cancer

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Autophagy and the pancreas: Healthy and disease states

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High-throughput screening for optimizing adoptive T cell therapies

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FLVCR1a Controls Cellular Cholesterol Levels through the Regulation of Heme Biosynthesis and Tricarboxylic Acid Cycle Flux in Endothelial Cells

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p53 increases phospholipid headgroup scavenging in senescence

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Photosensitive Hydrogel with Temperature‐Controlled Reversible Nano‐Apertures for Single‐Cell Protein Analysis

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Applying CRISPR Screen in Diabetes Research

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Reprogrammed mitochondria: a central hub of cancer cell metabolism

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Beyond Bulk Metabolomics: Emerging Technologies for Defining Cell-Type Specific Metabolic Pathways in Health and Disease

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Iron and metabolic rewiring in cancer

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Olaparib and Radiotherapy Induce Type I Interferon– and CD8+ T Cell–Dependent Sensitization to Immunotherapy in Pancreatic Cancer

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Integrated screens reveal that guanine nucleotide depletion, which is irreversible via targeting IMPDH2, inhibits pancreatic cancer and potentiates KRAS inhibition

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Establishment of Canine Oral Mucosal Melanoma Cell Lines and Their Xenogeneic Animal Models

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Arrayed CRISPR/Cas9 Screening for the Functional Validation of Cancer Genetic Dependencies

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Modelling and deciphering tumour metabolism in CRISPR screens

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Divergent iron regulatory states contribute to heterogeneity in breast cancer aggressiveness

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Multi-omic screening of invasive GBM cells in engineered biomaterials and patient biopsies reveals targetable transsulfuration pathway alterationsPreprint

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CRISPR/Cas9 genome engineering in PDAC: From preclinical studies to translation and clinical research

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The Dual Role of Autophagy in Cancer: Mechanisms and Therapeutic Strategies

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Stem cells: Mitochondrial biogenesis links growth and EGFR signaling

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Distinct Essentiality of the Mitochondrial Respiratory Chain in Proliferating Cells In Vivo

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P3H4 Promotes Malignant Progression of Lung Adenocarcinoma via Interaction with EGFR

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Porphyrin overdrive rewires pan-cancer cell metabolismPreprint

Adapa, S. R., Hunter, G. A., Amin, N. E., Marinescu, C., Borsky, A., Sagatys, E. M., Sebti, S. M., Reuther, G. W., Ferreira, G. C., & Jiang, R. H. Y. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.02.18.481061 · Cited by 3 · see citing works

Context‐Specific Metabolic Alterations in HPRT1 Knockout Cells Within a 3D Culture System

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A high throughput assay for phosphoribosylformylglycinamidine synthase

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Functional Genomics Identifies Metabolic Vulnerabilities in Pancreatic Cancer

Biancur, D. E., Kapner, K. S., Yamamoto, K., Banh, R. S., Neggers, J. E., Sohn, A. S. W., Wu, W., Manguso, R. T., Brown, A., Root, D. E., et al. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.10.018 · Cited by 82 · see citing works

Optical genomic mapping reveals balanced and unbalanced cytogenetic findings associated with tumor-forming potential in a prostate cancer cell line (M2205)

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Pancreatic cancer and adaptive metabolism in a nutrient-deficient environment

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Harnessing metabolic dependencies in pancreatic cancers

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Metabolism in Pancreatic Cancer

Poursaitidis, I., & Lamb, R. F. (2017) · Springer eBooks · doi:10.1007/978-1-4939-6631-8_68-1