Michalakis, Stylianos

Safety and Vision Outcomes of Subretinal Gene Therapy Targeting Cone Photoreceptors in Achromatopsia: A Nonrandomized Controlled Trial

Fischer, M. D., Michalakis, S., Wilhelm, B., Zobor, D., Muehlfriedel, R., Kohl, S., Weisschuh, N., Ochakovski, G. A., Klein, R., Schoen, C., et al. (2020) · JAMA Ophthalmology

Retinal Development and DisordersVirus-based gene therapy research

Cited by 177

AAV8 Can Induce Innate and Adaptive Immune Response in the Primate Eye

Reichel, F. F., Dauletbekov, D. L., Klein, R., Peters, T., Ochakovski, G. A., Seitz, I. P., Wilhelm, B., Ueffing, M., Biel, M., Wissinger, B., et al. (2017) · Molecular Therapy

Virus-based gene therapy researchRetinal Development and Disorders

Cited by 145

TET3 Is Recruited by REST for Context-Specific Hydroxymethylation and Induction of Gene Expression

Perera, A., Eisen, D., Wagner, M., Laube, S. K., Künzel, A. F., Koch, S., Steinbacher, J., Schulze, E., Splith, V., Mittermeier, N., et al. (2015) · Cell Reports

Epigenetics and DNA MethylationGenomics and Chromatin Dynamics

Cited by 145

Novel AAV capsids for intravitreal gene therapy of photoreceptor disorders

Pavlou, M., Schön, C., Occelli, L. M., Rossi, A., Meumann, N., Boyd, R. F., Bartoe, J. T., Siedlecki, J., Gerhardt, M. J., Babutzka, S., et al. (2021) · EMBO Molecular Medicine

Virus-based gene therapy researchRetinal Development and Disorders

Cited by 135

Superior retinal gene transfer and biodistribution profile of subretinal versus intravitreal delivery of AAV8 in nonhuman primates

Seitz, I. P., Michalakis, S., Wilhelm, B., Reichel, F. F., Ochakovski, G. A., Zrenner, E., Ueffing, M., Biel, M., Wissinger, B., Bartz-Schmidt, K. U., et al. (2017) · Investigative Opthalmology & Visual Science

Virus-based gene therapy researchRetinal Development and Disorders

Cited by 108

Humoral immune response after intravitreal but not after subretinal AAV8 in primates and patients

Reichel, F. F., Peters, T., Wilhelm, B., Biel, M., Ueffing, M., Wissinger, B., Bartz-Schmidt, K. U., Klein, R., Michalakis, S., Fischer, M. D., et al. (2018) · Investigative Opthalmology & Visual Science

Virus-based gene therapy researchRetinal Development and Disorders

Cited by 86

More than meets the eye: The role of microglia in healthy and diseased retina

Murenu, E., Gerhardt, M.-J., Biel, M., & Michalakis, S. (2022) · Frontiers in Immunology

Neuroinflammation and Neurodegeneration MechanismsRetinal Development and Disorders

Cited by 73

Gene therapy for achromatopsia

Michalakis, S., Schön, C., Becirovic, E., & Biel, M. (2017) · The Journal of Gene Medicine

Retinal Development and DisordersVirus-based gene therapy research

Cited by 41

Subretinal Injection for Gene Therapy Does Not Cause Clinically Significant Outer Nuclear Layer Thinning in Normal Primate Foveae

Ochakovski, G. A., Peters, T., Michalakis, S., Wilhelm, B., Wissinger, B., Biel, M., Bartz-Schmidt, K. U., Fischer, M. D., & for the RD-CURE Consortium (2017) · Investigative Opthalmology & Visual Science

Retinal Development and DisordersRetinal Diseases and Treatments

Cited by 38

Optimized Subretinal Injection Technique for Gene Therapy Approaches

Mühlfriedel, R., Michalakis, S., Garrido, M. G., Sothilingam, V., Schön, C., Biel, M., & Seeliger, M. W. (2019) · Methods in Molecular Biology

Retinal Development and DisordersVirus-based gene therapy research

Cited by 14