Ye, Dan

Inhibition of α-KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors

Xiao, M., Yang, H., Xu, W., Ma, S., Lin, H., Zhu, H., Liu, L., Liu, Y., Yang, C., Xu, Y., et al. (2012) · Genes & Development

Epigenetics and DNA MethylationCancer, Hypoxia, and Metabolism

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SIRT5 Desuccinylates and Activates Pyruvate Kinase M2 to Block Macrophage IL-1β Production and to Prevent DSS-Induced Colitis in Mice

Wang, F., Wang, K., Xu, W., Zhao, S., Ye, D., Wang, Y., Xu, Y., Zhou, L., Chu, Y., Zhang, C., et al. (2017) · Cell Reports

Sirtuins and Resveratrol in MedicineInflammasome and immune disorders

Cited by 340

Metabolism, Activity, and Targeting of D- and L-2-Hydroxyglutarates

Ye, D., Guan, K.-L., & Xiong, Y. (2018) · Trends in Cancer

Cancer, Hypoxia, and MetabolismBiochemical Acid Research Studies

Cited by 242

Oncometabolite D-2-Hydroxyglutarate Inhibits ALKBH DNA Repair Enzymes and Sensitizes IDH Mutant Cells to Alkylating Agents

Wang, P., Wu, J., Ma, S., Zhang, L., Yao, J., Hoadley, K. A., Wilkerson, M. D., Perou, C. M., Guan, K.-L., Ye, D., et al. (2015) · Cell Reports

Glioma Diagnosis and TreatmentDNA Repair Mechanisms

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Destabilization of Fatty Acid Synthase by Acetylation Inhibits De Novo Lipogenesis and Tumor Cell Growth

Lin, H.-P., Cheng, Z.-L., He, R.-Y., Song, L., Tian, M.-X., Zhou, L.-S., Groh, B. S., Liu, W.-R., Ji, M.-B., Ding, C., et al. (2016) · Cancer Research

Cancer, Lipids, and MetabolismLipid metabolism and biosynthesis

Cited by 150

SIRT5 deficiency suppresses mitochondrial ATP production and promotes AMPK activation in response to energy stress

Zhang, M., Wu, J., Sun, R., Tao, X., Wang, X., Kang, Q., Wang, H., Zhang, L., Liu, P., Zhang, J., et al. (2019) · PLOS ONE

Sirtuins and Resveratrol in MedicineMitochondrial Function and Pathology

Cited by 72

Hyperactivation of TORC1 drives resistance to the pan-HER tyrosine kinase inhibitor neratinib in HER2-mutant cancers

Sudhan, D. R., Guerrero-Zotano, A., Won, H., González Ericsson, P., Servetto, A., Huerta-Rosario, M., Ye, D., Lee, K.-M., Formisano, L., Guo, Y., et al. (2020) · Cancer Cell

PI3K/AKT/mTOR signaling in cancerHER2/EGFR in Cancer Research

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Single-Cell RNA-Sequencing and Optical Electrophysiology of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes Reveal Discordance Between Cardiac Subtype-Associated Gene Expression Patterns and Electrophysiological Phenotypes

Biendarra-Tiegs, S. M., Li, X., Ye, D., Brandt, E. B., Ackerman, M. J., & Nelson, T. J. (2019) · Stem Cells and Development

Pluripotent Stem Cells ResearchCardiac electrophysiology and arrhythmias

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