SIRT5 deficiency suppresses mitochondrial ATP production and promotes AMPK activation in response to energy stress
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Sirtuin 5 (SIRT5) is a member of the NAD+-dependent sirtuin family of protein deacylase that catalyzes removal of post-translational modifications, such as succinylation, malonylation, and glutarylation on lysine residues. In light of the SIRT5's roles in regulating mitochondrion function, we show here that SIRT5 deficiency leads to suppression of mitochondrial NADH oxidation and inhibition of ATP synthase activity. As a result, SIRT5 deficiency decreases mitochondrial ATP production, increases AMP/ATP ratio, and subsequently activates AMP-activated protein kinase (AMPK) in cultured cells and mouse hearts under energy stress conditions. Moreover, Sirt5 knockout attenuates transverse aortic constriction (TAC)-induced cardiac hypertrophy and cardiac dysfunction in mice, which is associated with decreased ATP level, increased AMP/ATP ratio and enhanced AMPK activation. Our study thus uncovers an important role of SIRT5 in regulating cellular energy metabolism and AMPK activation in response to energy stress.
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SIRT5 controls cellular energy metabolism by AMPK activation upon energy stress, which further confirms the cardioprotective role of AMPK in left ventricular hypertrophy under the stress of pressure overload.
“Thus, this study unveils a crucial role of SIRT5 in controlling cellular energy metabolism by AMPK activation upon energy stress, which further confirms the cardioprotective role of AMPK in left ventricular hypertrophy under the stress of pressure overload [138].”
From AMPK, Mitochondrial Function, and Cardiovascular Disease (2020) · cites this paper as [138]
SIRT5 plays a vital role in mitochondrial function via increased mitochondrial nicotinamide adenine dinucleotide and ATP synthase activity.
“SIRT5, primarily localizing at the mitochondrial matrix, plays a vital role in mitochondrial function via increased mitochondrial nicotinamide adenine dinucleotide and ATP synthase activity [138].”
From AMPK, Mitochondrial Function, and Cardiovascular Disease (2020) · cites this paper as [138]
SIRT5 deficiency attenuated ATP production from mitochondrial ETC, increased the AMP-to-ATP ratio, and in turn activated AMPK in both cultured cells and hearts under the conditions of energy stress.
“SIRT5 deficiency attenuated ATP production from mitochondrial ETC, increased the AMP-to-ATP ratio, and in turn activated AMPK in both cultured cells and hearts under the conditions of energy stress [138].”
From AMPK, Mitochondrial Function, and Cardiovascular Disease (2020) · cites this paper as [138]
SIRT5 ablation attenuated cardiac hypertrophy and cardiac dysfunction in the TAC model, which is accompanied by the reduction of ATP, increase of AMP-to-ATP ratio, and enhancement of AMPK activity.
“Consistently, SIRT5 ablation attenuated cardiac hypertrophy and cardiac dysfunction in the TAC model, which is accompanied by the reduction of ATP, increase of AMP-to-ATP ratio, and enhancement of AMPK activity [138].”
From AMPK, Mitochondrial Function, and Cardiovascular Disease (2020) · cites this paper as [138]
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- Authors
- Zhang, M., Wu, J., Sun, R., Tao, X., Wang, X., Kang, Q., Wang, H., Zhang, L., Liu, P., Zhang, J., Xia, Y., Zhao, Y., Yang, Y., Xiong, Y., Guan, K.-L., Zou, Y., & Ye, D.
- Affiliations
- Shanghai Medical College of Fudan University (CN)
- Fudan University (CN)
- Waters (China) (CN)
- East China University of Science and Technology (CN)
- University of North Carolina at Chapel Hill (US)
- Corresponding author
- Guan, Kun-Liang
- Zou, Yunzeng
- Ye, Dan
- ORCID
- Venue
- PLOS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2019-02-13
- Volume
- 14
- Issue
- 2
- Pages
- e0211796
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC6373945
- OpenAlex
- W2914070955
- Cited by
- 72
- References
- 70
- Citations by year
- 2026: 4 · 2025: 12 · 2024: 13 · 2023: 7 · 2022: 11 · 2021: 11 · 2020: 9 · 2019: 5
- FWCI
- 4.74
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- PLoS ONE (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- eScholarship (California Digital Library) (submittedVersion)
- eScholarship (California Digital Library) (submittedVersion, cc-by)
- Figshare (submittedVersion, cc-by)
- Funders
- the National Key R&D Program of China (2016YFA0501800)
- National Natural Science Foundation of China (31871431, 81522033)
- the Shanghai Committee of Science and Technology, China (16JC1404000)
- National Institutes of Health (GM067113, CA063834, CA196878, GM51586)
- Waters corporation Shanghai Science & Technology Co Ltd (Salary)
- Topics
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Keywords
- SIRT5, sirtuins, mitochondrial ATP production, AMPK activation, energy stress, NADH oxidation, ATP synthase, succinylation, malonylation, AMP/ATP ratio, cardiac hypertrophy, transverse aortic constriction, heart failure, cellular energy metabolism
- MeSH terms
- Adenosine Triphosphate, Animals, Enzyme Activation, Cardiomegaly, Humans, Mitochondria, Heart, Stress, Physiological, Mice, Knockout, Sirtuins, Mice, AMP-Activated Protein Kinases, HEK293 Cells
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