Fischer, Marcus

Wnt pathway inhibition via the targeting of Frizzled receptors results in decreased growth and tumorigenicity of human tumors

Gurney, A., Axelrod, F., Bond, C. J., Cain, J., Chartier, C., Donigan, L., Fischer, M., Chaudhari, A., Ji, M., Kapoun, A. M., et al. (2012) · Proceedings of the National Academy of Sciences

Wnt/β-catenin signaling in development and cancerHedgehog Signaling Pathway Studies

Cited by 614

Incorporation of protein flexibility and conformational energy penalties in docking screens to improve ligand discovery.

Fischer, M., Coleman, R. G., Fraser, J. S., & Shoichet, B. K. (2014) · Nature Chemistry

Computational Drug Discovery MethodsProtein Structure and Dynamics

Cited by 149

Selective CK1α degraders exert antiproliferative activity against a broad range of human cancer cell lines

Nishiguchi, G., Mascibroda, L. G., Young, S. M., Caine, E. A., Abdelhamed, S., Kooijman, J. J., Miller, D. J., Das, S., McGowan, K., Mayasundari, A., et al. (2024) · Nature Communications

Protein Degradation and InhibitorsUbiquitin and proteasome pathways

Cited by 57