Thorpe, Robin

"Cytokine Storm" in the Phase I Trial of Monoclonal Antibody TGN1412: Better Understanding the Causes to Improve PreClinical Testing of Immunotherapeutics

Stebbings, R., Findlay, L., Edwards, C., Eastwood, D., Bird, C., North, D., Mistry, Y., Dilger, P., Liefooghe, E., Cludts, I., et al. (2007) · The Journal of Immunology

Immunotoxicology and immune responsesMonoclonal and Polyclonal Antibodies Research

Cited by 316

Monoclonal antibody TGN1412 trial failure explained by species differences in CD28 expression on CD4 + effector memory T‐cells

Eastwood, D., Findlay, L., Poole, S., Bird, C., Wadhwa, M., Moore, M., Burns, C., Thorpe, R., & Stebbings, R. (2010) · British Journal of Pharmacology

Immunotoxicology and immune responsesMonoclonal and Polyclonal Antibodies Research

Cited by 300

Cytokine gene expression in a murine wound healing model

Bryan, D., Walker, K. B., Ferguson, M., & Thorpe, R. (2005) · Cytokine

Wound Healing and TreatmentsInflammation biomarkers and pathways

Cited by 80

Improved in vitro methods to predict the in vivo toxicity in man of therapeutic monoclonal antibodies including TGN1412

Findlay, L., Eastwood, D., Stebbings, R., Sharp, G., Mistry, Y., Ball, C., Hood, J., Thorpe, R., & Poole, S. (2010) · Journal of Immunological Methods

Monoclonal and Polyclonal Antibodies ResearchImmunotoxicology and immune responses

Cited by 74

After TGN1412: Recent developments in cytokine release assays

Stebbings, R., Eastwood, D., Poole, S., & Thorpe, R. (2013) · Journal of Immunotoxicology

Immunotoxicology and immune responsesAnimal testing and alternatives

Cited by 73

Safety of biologics, lessons learnt from TGN1412

Stebbings, R., Poole, S., & Thorpe, R. (2009) · Current Opinion in Biotechnology

Biosimilars and Bioanalytical MethodsImmunotoxicology and immune responses

Cited by 70

Severity of the TGN 1412 trial disaster cytokine storm correlated with IL‐2 release

Eastwood, D., Bird, C., Dilger, P., Hockley, J., Findlay, L., Poole, S., Thorpe, S. J., Wadhwa, M., Thorpe, R., & Stebbings, R. (2013) · British Journal of Clinical Pharmacology

Monoclonal and Polyclonal Antibodies ResearchImmunotoxicology and immune responses

Cited by 58

Systematic comparison and validation of quantitative real-time PCR methods for the quantitation of adeno-associated viral products

Werling, N. J., Satkunanathan, S., Thorpe, R., & Zhao, Y. (2015) · Human Gene Therapy Methods

Virus-based gene therapy researchMolecular Biology Techniques and Applications

Cited by 53

Endothelial cells co-stimulate peripheral blood mononuclear cell responses to monoclonal antibody TGN1412 in culture

Findlay, L., Sharp, G., Fox, B., Ball, C., Robinson, C. J., Bird, C., Stebbings, R., Eastwood, D., Wadhwa, M., Poole, S., et al. (2011) · Cytokine

Immunotoxicology and immune responsesMonoclonal and Polyclonal Antibodies Research

Cited by 29

The function of DNA binding protein nucleophosmin in AAV replication

Satkunanathan, S., Thorpe, R., & Zhao, Y. (2017) · Virology

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 24