Cotton, Thomas R.

When two’s a crowd - Structural mapping of PEAK pseudokinase interactions identifies 14 3 3 as a molecular switch for PEAK3/Crk signaling.

Lucet, I., Roy, M., Surudoi, M., Kropp, A., Hou, J., Dai, W., Hardy, J., Liang, L.-Y., Cotton, T., Lechtenberg, B., et al. (2022) · Nature Communications

14-3-3 protein interactionsProtein Kinase Regulation and GTPase Signaling

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Activation of CAMK2 by pseudokinase PEAK1 represents a targetable pathway in triple negative breast cancer

Yang, X., Ma, X., Zhao, T., Croucher, D. R., Nguyen, E. V., Clark, K. C., Hu, C., Latham, S. L., Bayly-Jones, C., Nguyen, B. V., et al. (2025) · Nature Communications

Protein Kinase Regulation and GTPase SignalingCancer Mechanisms and Therapy

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Feed-forward stimulation of CAMK2 by the oncogenic pseudokinase PEAK1 generates a therapeutically ‘actionable’ signalling axis in triple negative breast cancer

Yang, X., Ma, X., Zhao, T., Croucher, D. R., Nguyen, E. V., Clark, K. C., Hu, C., Latham, S. L., Bayly-Jones, C., Nguyen, V. C. B., et al. (2024) · Nature Communications

Protein Kinase Regulation and GTPase SignalingCancer Mechanisms and Therapy

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