Tomchick, Diana R.

Artificial ligand binding within the HIF2α PAS-B domain of the HIF2 transcription factor

Scheuermann, T. H., Tomchick, D. R., Machius, M., Guo, Y., Bruick, R. K., & Gardner, K. H. (2009) · Proceedings of the National Academy of Sciences

Cancer, Hypoxia, and MetabolismHemoglobin structure and function

Cited by 301

Munc13 C2B domain is an activity-dependent Ca2+ regulator of synaptic exocytosis

Shin, O.-H., Lu, J., Rhee, J.-S., Tomchick, D. R., Pang, Z. P., Wojcik, S. M., Camacho-Perez, M., Brose, N., Machius, M., Rizo, J., et al. (2010) · Nature Structural & Molecular Biology

Cellular transport and secretionNeuroscience and Neuropharmacology Research

Cited by 243

Structure of cohesin subcomplex pinpoints direct shugoshin-Wapl antagonism in centromeric cohesion

Hara, K., Zheng, G., Qu, Q., Liu, H., Ouyang, Z., Chen, Z., Tomchick, D. R., & Yu, H. (2014) · Nature Structural & Molecular Biology

Microtubule and mitosis dynamicsGenomics and Chromatin Dynamics

Cited by 166

Structural and Energetic Mechanisms of Cooperative Autoinhibition and Activation of Vav1

Yu, B., Martins, I. R. S., Li, P., Amarasinghe, G. K., Umetani, J., Fernandez-Zapico, M. E., Billadeau, D. D., Machius, M., Tomchick, D. R., & Rosen, M. K. (2010) · Cell

Protein Kinase Regulation and GTPase SignalingProtein Structure and Dynamics

Cited by 156

Dynamic binding mode of a Synaptotagmin-1–SNARE complex in solution

Brewer, K. D., Bacaj, T., Cavalli, A., Camilloni, C., Swarbrick, J. D., Liu, J., Zhou, A., Zhou, P., Barlow, N., Xu, J., et al. (2015) · Nature Structural & Molecular Biology

Cellular transport and secretionNeuroscience and Neuropharmacology Research

Cited by 142

Structural Basis for a Munc13–1 Homodimer to Munc13–1/RIM Heterodimer Switch

Lu, J., Machius, M., Dulubova, I., Dai, H., Südhof, T. C., Tomchick, D. R., & Rizo, J. (2006) · PLoS Biology

Cellular transport and secretionNeuroscience and Neuropharmacology Research

Cited by 132

Mechanistic insights into neurotransmitter release and presynaptic plasticity from the crystal structure of Munc13-1 C1C2BMUN

Xu, J., Camacho, M., Xu, Y., Esser, V., Liu, X., Trimbuch, T., Pan, Y.-Z., Ma, C., Tomchick, D. R., Rosenmund, C., et al. (2017) · eLife

Cellular transport and secretionNeuroscience and Neuropharmacology Research

Cited by 119

Structure of the human cohesin inhibitor Wapl

Ouyang, Z., Zheng, G., Song, J., Borek, D. M., Otwinowski, Z., Brautigam, C. A., Tomchick, D. R., Rankin, S., & Yu, H. (2013) · Proceedings of the National Academy of Sciences

Microtubule and mitosis dynamicsGenomics and Chromatin Dynamics

Cited by 84

Structural and molecular characterization of iron-sensing hemerythrin-like domain within F-box and leucine-rich repeat protein 5 (FBXL5)

Thompson, J. W., Salahudeen, A. A., Chollangi, S., Ruiz, J. C., Brautigam, C. A., Makris, T. M., Lipscomb, J. D., Tomchick, D. R., & Bruick, R. K. (2012) · Journal of Biological Chemistry

Iron Metabolism and DisordersHemoglobin structure and function

Cited by 71

Crystal Structure of the Tp34 (TP0971) Lipoprotein of Treponema pallidum

Deka, R. K., Brautigam, C. A., Tomson, F. L., Lumpkins, S. B., Tomchick, D. R., Machius, M., & Norgard, M. V. (2007) · Journal of Biological Chemistry

Syphilis Diagnosis and TreatmentEnzyme Structure and Function

Cited by 50

Biochemical and structural insights into a 5’ to 3’ RNA ligase reveal a potential role in tRNA ligation

Hu, Y., Lopez, V. A., Xu, H., Pfister, J. P., Song, B., Servage, K. A., Sakurai, M., Jones, B. T., Mendell, J. T., Wang, T., et al. (2024) · Proceedings of the National Academy of Sciences

RNA and protein synthesis mechanismsRNA modifications and cancer

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