Munc13 C2B domain is an activity-dependent Ca2+ regulator of synaptic exocytosis
Open accessAbstract
Munc13 is a multidomain protein present in presynaptic active zones that mediates the priming and plasticity of synaptic vesicle exocytosis, but the mechanisms involved remain unclear. Here we use biophysical, biochemical and electrophysiological approaches to show that the central C(2)B domain of Munc13 functions as a Ca(2+) regulator of short-term synaptic plasticity. The crystal structure of the C(2)B domain revealed an unusual Ca(2+)-binding site with an amphipathic alpha-helix. This configuration confers onto the C(2)B domain unique Ca(2+)-dependent phospholipid-binding properties that favor phosphatidylinositolphosphates. A mutation that inactivated Ca(2+)-dependent phospholipid binding to the C(2)B domain did not alter neurotransmitter release evoked by isolated action potentials, but it did depress release evoked by action-potential trains. In contrast, a mutation that increased Ca(2+)-dependent phosphatidylinositolbisphosphate binding to the C(2)B domain enhanced release evoked by isolated action potentials and by action-potential trains. Our data suggest that, during repeated action potentials, Ca(2+) and phosphatidylinositolphosphate binding to the Munc13 C(2)B domain potentiate synaptic vesicle exocytosis, thereby offsetting synaptic depression induced by vesicle depletion.
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The C2B domain of Munc13 binds Ca2+ with a relatively high affinity, but only in the presence of phosphatidyl-inositolphosphates.
“The C2B domain of Munc13—the only Munc13 signaling domain shared by all isoforms (Figure 2)—binds Ca2+ with a relatively high affinity, but only in the presence of phosphatidyl-inositolphosphates (Shin et al., 2010).”
From The Presynaptic Active Zone (2012) · cites this paper as Shin et al., 2010
The Results sections on Ca2+ binding and Ca2+/phospholipid binding report that Munc13 C2B binds Ca2+ and has an apparent Ca2+ affinity of about 5.5 μM in a liposome-binding assay. But the Ca2+-binding experiments also demonstrate binding by purified C2B domains without phosphatidylinositolphosphates. The PIP/PIP2 requirement concerns Ca2+-dependent phospholipid binding, not Ca2+ binding itself; page numbers are unavailable in our copy. (LLM, conf=0.88)
Experimental — accuracy not yet measuredBlocking of Ca2+ binding to the C2B domain by a mutation in Munc13 dramatically depresses neurotransmitter release during action potential trains.
“Blocking of Ca2+ binding to the C2B domain by a mutation in Munc13 dramatically depresses neurotransmitter release during action potential trains”
From The Presynaptic Active Zone (2012) · cites this paper as Shin et al., 2010
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- Authors
- Shin, O.-H., Lu, J., Rhee, J.-S., Tomchick, D. R., Pang, Z. P., Wojcik, S. M., Camacho-Perez, M., Brose, N., Machius, M., Rizo, J., Rosenmund, C., & Südhof, T. C.
- Affiliations
- The University of Texas Southwestern Medical Center (US)
- Max Planck Society (DE)
- Baylor College of Medicine (US)
- Max Planck Institute of Experimental Medicine (DE)
- Howard Hughes Medical Institute (US)
- Corresponding author
- Rizo, Josep
- Rosenmund, Christian
- Südhof, Thomas C
- ORCID
- Venue
- Nature Structural & Molecular Biology
- Published
- 2010-02-14
- Volume
- 17
- Issue
- 3
- Pages
- 280-288
- ISSN
- 1545-9985 (ISSN-L)
- 1545-9993
- PMC
- PMC2916016
- OpenAlex
- W2133603739
- Cited by
- 243
- References
- 73
- Citations by year
- 2026: 7 · 2025: 17 · 2024: 5 · 2023: 12 · 2022: 23 · 2021: 19 · 2020: 12 · 2019: 10 · 2018: 17 · 2017: 25 · 2016: 7 · 2015: 14 · 2014: 20 · 2013: 15 · 2012: 18
- FWCI
- 7.56
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- Locations
- Nature Structural & Molecular Biology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Max Planck Institute for Plasma Physics (submittedVersion)
- GRO (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Funders
- Howard Hughes Medical Institute
- National Institute of Neurological Disorders and Stroke (NS40944, R01NS051262, NS051262, R01NS040944)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Keywords
- Munc13, C2B domain, synaptic vesicle exocytosis, calcium binding, phospholipid binding, phosphoinositides, phosphatidylinositol bisphosphate, short-term plasticity, action potential trains, synaptic depression, vesicle depletion, active zone, vesicle priming, crystal structure
- MeSH terms
- Amino Acid Sequence, Animals, Calcium, Electrophysiology, Exocytosis, Molecular Sequence Data, Nerve Tissue Proteins, Synaptic Transmission, Magnetic Resonance Spectroscopy, Phospholipids, Spectrometry, Fluorescence, Synaptic Vesicles, Sequence Homology, Amino Acid, Protein Structure, Tertiary, Crystallography, X-Ray, Rats
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