LeBrasseur, Nathan K.

p21 induces a senescence program and skeletal muscle dysfunction

Englund, D. A., Jolliffe, A., Aversa, Z., Zhang, X., Sturmlechner, I., Sakamoto, A. E., Zeidler, J. D., Warner, G. M., McNinch, C., White, T. A., et al. (2023) · Molecular Metabolism

Telomeres, Telomerase, and SenescenceMuscle Physiology and Disorders

Cited by 90

Local senolysis in aged mice only partially replicates the benefits of systemic senolysis

Farr, J. N., Saul, D., Doolittle, M. L., Kaur, J., Rowsey, J. L., Vos, S. J., Froemming, M. N., Lagnado, A. B., Zhu, Y., Weivoda, M., et al. (2023) · Journal of Clinical Investigation

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 81

Changes in Function and Disability After Resistance Training: Does Velocity Matter?: A Pilot Study

Sayers, S. P., Bean, J., Cuoco, A., LeBrasseur, N. K., Jette, A., & Fielding, R. A. (2003) · American Journal of Physical Medicine & Rehabilitation

Balance, Gait, and Falls PreventionPhysical Activity and Health

Cited by 79

Associations between biomarkers of cellular senescence and physical function in humans: observations from the lifestyle interventions for elders (LIFE) study

Fielding, R. A., Atkinson, E. J., Aversa, Z., White, T. A., Heeren, A. A., Achenbach, S. J., Mielke, M. M., Cummings, S. R., Pahor, M., Leeuwenburgh, C., et al. (2022) · GeroScience

Telomeres, Telomerase, and SenescenceNutrition and Health in Aging

Cited by 75

Exercise Counters the Age-Related Accumulation of Senescent Cells

Zhang, X., Englund, D. A., Aversa, Z., Jachim, S. K., White, T. A., & LeBrasseur, N. K. (2022) · Exercise and Sport Sciences Reviews

Telomeres, Telomerase, and SenescenceExercise and Physiological Responses

Cited by 63

Corrigendum to ‘Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease’ EBioMedicine 47 (2019) 446–456

Hickson, L. J., Langhi Prata, L. G. P., Bobart, S. A., Evans, T. K., Giorgadze, N., Hashmi, S. K., Herrmann, S. M., Jensen, M. D., Jia, Q., Jordan, K. L., et al. (2020) · EBioMedicine

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 59

Understanding heterogeneity of responses to, and optimizing clinical efficacy of, exercise training in older adults: NIH NIA Workshop summary

Erickson, M. L., Allen, J. M., Beavers, D. P., Collins, L. M., Davidson, K. W., Erickson, K. I., Esser, K. A., Hesselink, M. K. C., Moreau, K. L., Laber, E. B., et al. (2023) · GeroScience

Cardiovascular and exercise physiologyPhysical Activity and Health

Cited by 47

Building muscle, browning fat and preventing obesity by inhibiting myostatin

LeBrasseur, N. K. (2012) · Diabetologia

Adipose Tissue and MetabolismMuscle Physiology and Disorders

Cited by 46

Distinct senotypes in p16- and p21-positive cells across human and mouse aging tissues

Saul, D., Jurk, D., Doolittle, M. L., Kosinsky, R. L., Han, Y., Zhang, X., Franco, A. C., Kim, S. Y., Wyles, S. P., Prakash, Y. S., et al. (2025) · The EMBO Journal

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 45

Advancing biological understanding of cellular senescence with computational multiomics

Li, S., Agudelo Garcia, P. A., Aliferis, C., Becich, M. J., Calyeca, J., Cosgrove, B. D., Elisseeff, J., Farzad, N., Fertig, E. J., Glass, C., et al. (2025) · Nature Genetics

Telomeres, Telomerase, and SenescenceSingle-cell and spatial transcriptomics

Cited by 40

Biomarkers of cellular senescence predict the onset of mobility disability and are reduced by physical activity in older adults

Fielding, R. A., Atkinson, E. J., Aversa, Z., White, T. A., Heeren, A. A., Mielke, M. M., Cummings, S. R., Pahor, M., Leeuwenburgh, C., & LeBrasseur, N. K. (2024) · The Journals of Gerontology: Series A

Telomeres, Telomerase, and SenescenceFrailty in Older Adults

Cited by 38

High prevalence of frailty in patients with adrenal adenomas and adrenocortical hormone excess: a cross-sectional multi-centre study with prospective enrolment

Dogra, P., Šambula, L., Saini, J., Thangamuthu, K., Athimulam, S., Delivanis, D. A., Baikousi, D. A., Nathani, R., Zhang, C. D., Genere, N., et al. (2023) · European Journal of Endocrinology

Frailty in Older AdultsAdrenal and Paraganglionic Tumors

Cited by 38

In vitro and in vivo effects of zoledronic acid on senescence and senescence-associated secretory phenotype markers

Samakkarnthai, P., Saul, D., Zhang, L., Aversa, Z., Doolittle, M. L., Sfeir, J. G., Kaur, J., Atkinson, E. J., Edwards, J. R., Russell, G. G., et al. (2023) · Aging

Telomeres, Telomerase, and SenescenceBone health and treatments

Cited by 34

Distinct secretomes in p16- and p21- positive senescent cells across tissues

Saul, D., Jurk, D., Doolittle, M. L., Kosinsky, R. L., Monroe, D. G., LeBrasseur, N. K., Robbins, P. D., Niedernhofer, L. J., Khosla, S., & Passos, J. F. (2023) · bioRxiv (Cold Spring Harbor Laboratory)

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 28