Espey, Michael Graham

Pharmacologic ascorbic acid concentrations selectively kill cancer cells: Action as a pro-drug to deliver hydrogen peroxide to tissues

Chen, Q., Espey, M. G., Krishna, M. C., Mitchell, J. B., Corpe, C. P., Buettner, G. R., Shacter, E., & Levine, M. (2005) · Proceedings of the National Academy of Sciences

Vitamin C and Antioxidants ResearchCancer and biochemical research

Cited by 1,075

Pharmacologic doses of ascorbate act as a prooxidant and decrease growth of aggressive tumor xenografts in mice

Chen, Q., Espey, M. G., Sun, A. Y., Pooput, C., Kirk, K. L., Krishna, M. C., Khosh, D. B., Drisko, J., & Levine, M. (2008) · Proceedings of the National Academy of Sciences

Vitamin C and Antioxidants ResearchCancer and biochemical research

Cited by 854

Ascorbate in pharmacologic concentrations selectively generates ascorbate radical and hydrogen peroxide in extracellular fluid in vivo

Chen, Q., Espey, M. G., Sun, A. Y., Lee, J.-H., Krishna, M. C., Shacter, E., Choyke, P. L., Pooput, C., Kirk, K. L., Buettner, G. R., et al. (2007) · Proceedings of the National Academy of Sciences

Vitamin C and Antioxidants ResearchRedox biology and oxidative stress

Cited by 676

The emerging biology of the nitrite anion

Gladwin, M. T., Schechter, A. N., Kim-Shapiro, D. B., Patel, R. P., Hogg, N., Shiva, S., Cannon, R. O., Kelm, M., Wink, D. A., Espey, M. G., et al. (2005) · Nature Chemical Biology

Nitric Oxide and Endothelin EffectsRedox biology and oxidative stress

Cited by 609

Role of oxygen gradients in shaping redox relationships between the human intestine and its microbiota

Espey, M. G. (2013) · Free Radical Biology and Medicine

Gut microbiota and healthRedox biology and oxidative stress

Cited by 396

Vitamin C: A concentration-function approach yields pharmacology and therapeutic discoveries

Levine, M., Padayatty, S. J., & Espey, M. G. (2011) · Advances in Nutrition

Vitamin C and Antioxidants ResearchAntioxidant Activity and Oxidative Stress

Cited by 357

Nitric oxide-induced cellular stress and p53 activation in chronic inflammation

Hofseth, L. J., Saito, S., Hussain, S. P., Espey, M. G., Miranda, K. M., Araki, Y., Jhappan, C., Higashimoto, Y., He, P., Linke, S. P., et al. (2003) · Proceedings of the National Academy of Sciences

Cancer-related Molecular PathwaysRedox biology and oxidative stress

Cited by 355

The chemistry of nitrosative stress induced by nitric oxide and reactive nitrogen oxide species. Putting perspective on stressful biological situations

Ridnour, L. A., Thomas, D. D., Mancardi, D., Espey, M. G., Miranda, K. M., Paolocci, N., Feelisch, M., Fukuto, J., & Wink, D. A. (2004) · Biological Chemistry

Nitric Oxide and Endothelin EffectsRedox biology and oxidative stress

Cited by 312

Vitamin C: Intravenous Use by Complementary and Alternative Medicine Practitioners and Adverse Effects

Padayatty, S. J., Sun, A. Y., Chen, Q., Espey, M. G., Drisko, J., & Levine, M. (2010) · PLoS ONE

Complementary and Alternative Medicine StudiesVitamin C and Antioxidants Research

Cited by 304

Hypoxic inducible factor 1α, extracellular signal-regulated kinase, and p53 are regulated by distinct threshold concentrations of nitric oxide

Thomas, D. D., Espey, M. G., Ridnour, L. A., Hofseth, L. J., Mancardi, D., Harris, C. C., & Wink, D. A. (2004) · Proceedings of the National Academy of Sciences

Cancer, Hypoxia, and MetabolismNitric Oxide and Endothelin Effects

Cited by 289

A biochemical rationale for the discrete behavior of nitroxyl and nitric oxide in the cardiovascular system

Miranda, K. M., Paolocci, N., Katori, T., Thomas, D. D., Ford, E., Bartberger, M. D., Espey, M. G., Kass, D. A., Feelisch, M., Fukuto, J. M., et al. (2003) · Proceedings of the National Academy of Sciences

Nitric Oxide and Endothelin EffectsRedox biology and oxidative stress

Cited by 283

Thrombospondin-1 inhibits endothelial cell responses to nitric oxide in a cGMP-dependent manner

Isenberg, J. S., Ridnour, L. A., Perruccio, E. M., Espey, M. G., Wink, D. A., & Roberts, D. D. (2005) · Proceedings of the National Academy of Sciences

Angiogenesis and VEGF in CancerNitric Oxide and Endothelin Effects

Cited by 273

The biphasic nature of nitric oxide responses in tumor biology

Ridnour, L. A., Thomas, D. D., Donzelli, S., Espey, M. G., Roberts, D. D., Wink, D. A., & Isenberg, J. S. (2006) · Antioxidants & Redox Signaling

Nitric Oxide and Endothelin EffectsAngiogenesis and VEGF in Cancer

Cited by 247

Vitamin C transporter Slc23a1 links renal reabsorption, vitamin C tissue accumulation, and perinatal survival in mice

Corpe, C. P., Tu, H., Eck, P., Wang, J., Faulhaber-Walter, R., Schnermann, J., Margolis, S., Padayatty, S., Sun, H., Wang, Y., et al. (2010) · Journal of Clinical Investigation

Vitamin C and Antioxidants ResearchIron Metabolism and Disorders

Cited by 162

Superoxide fluxes limit nitric oxide-induced signaling

Thomas, D. D., Ridnour, L. A., Espey, M. G., Donzelli, S., Ambs, S., Hussain, S. P., Harris, C. C., DeGraff, W., Roberts, D. D., Mitchell, J. B., et al. (2006) · Journal of Biological Chemistry

Nitric Oxide and Endothelin EffectsRedox biology and oxidative stress

Cited by 121

Discriminating formation of HNO from other reactive nitrogen oxide species

Donzelli, S., Espey, M. G., Thomas, D. D., Mancardi, D., Tocchetti, C. G., Ridnour, L. A., Paolocci, N., King, S. B., Miranda, K. M., Lazzarino, G., et al. (2006) · Free Radical Biology and Medicine

Nitric Oxide and Endothelin EffectsRedox biology and oxidative stress

Cited by 112

Generation of nitroxyl by heme protein-mediated peroxidation of hydroxylamine but not N-hydroxy-l-arginine

Donzelli, S., Espey, M. G., Flores-Santana, W., Switzer, C. H., Yeh, G. C., Huang, J., Stuehr, D. J., King, S. B., Miranda, K. M., & Wink, D. A. (2008) · Free Radical Biology and Medicine

Hemoglobin structure and functionNitric Oxide and Endothelin Effects

Cited by 91

Heme Proteins and Nitric Oxide (NO): The Neglected, Eloquent Chemistry in NO Redox Signaling and Regulation

Thomas, D. D., Miranda, K. M., Colton, C. A., Citrin, D., Espey, M. G., & Wink, D. A. (2003) · Antioxidants & Redox Signaling

Hemoglobin structure and functionMetal-Catalyzed Oxygenation Mechanisms

Cited by 89

Inhibition of poly(ADP-ribose) polymerase (PARP) by nitric oxide and reactive nitrogen oxide species

Sidorkina, O., Espey, M. G., Miranda, K. M., Wink, D. A., & Laval, J. (2003) · Free Radical Biology and Medicine

Redox biology and oxidative stressPARP inhibition in cancer therapy

Cited by 79

Hypoxia modulates nitric oxide-induced regulation of NMDA receptor currents and neuronal cell death

Gbadegesin, M., Vicini, S., Hewett, S. J., Wink, D. A., Espey, M., Pluta, R. M., & Colton, C. A. (1999) · American Journal of Physiology-Cell Physiology

Neuroscience and Neuropharmacology ResearchNitric Oxide and Endothelin Effects

Cited by 47

Nitroxyl anion regulation of the NMDA receptor

Colton, C. A., Gbadegesin, M., Wink, D. A., Miranda, K. M., Espey, M. G., & Vicini, S. (2001) · Journal of Neurochemistry

Neuroscience and Neuropharmacology ResearchNitric Oxide and Endothelin Effects

Cited by 45

Comparison of control of Listeria by nitric oxide redox chemistry from murine macrophages and no donors: insights into listeriocidal activity of oxidative and nitrosative stress

Ogawa, R., Pacelli, R., Espey, M. G., Miranda, K. M., Friedman, N., Kim, S., Cox, G., Mitchell, J. B., Wink, D. A., & Russo, A. (2001) · Free Radical Biology and Medicine

Nitric Oxide and Endothelin EffectsRedox biology and oxidative stress

Cited by 35

In vitro and in vivo effects of probucol on hydrolysis of asymmetric dimethyl L-arginine and vasospasm in primates

Pluta, R. M., Jung, C. S., Harvey-White, J., Whitehead, A., Shilad, S., Espey, M. G., & Oldfield, E. H. (2005) · Journal of neurosurgery

Nitric Oxide and Endothelin EffectsIntracranial Aneurysms: Treatment and Complications

Cited by 20