Downing, James R.

Molecular classification of cancer: class discovery and class prediction by gene expression monitoring

Golub, T. R., Slonim, D. K., Tamayo, P., Huard, C., Gaasenbeek, M., Mesirov, J. P., Coller, H., Loh, M. L., Downing, J. R., Caligiuri, M. A., et al. (1999) · Science

Gene expression and cancer classificationBreast Cancer Treatment Studies

Cited by 11,516

Data-Driven Phenotypic Dissection of AML Reveals Progenitor-like Cells that Correlate with Prognosis

Levine, J. H., Simonds, E. F., Bendall, S. C., Davis, K. L., Amir, E.-A. D., Tadmor, M. D., Litvin, O., Fienberg, H. G., Jager, A., Zunder, E. R., et al. (2015) · Cell

Acute Myeloid Leukemia ResearchSingle-cell and spatial transcriptomics

Cited by 2,303

AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis.

Okuda, T., van Deursen, J., Hiebert, S. W., Grosveld, G., & Downing, J. R. (1996) · Cell

Acute Myeloid Leukemia ResearchHematopoietic Stem Cell Transplantation

Cited by 1,856

The genetic basis of early T-cell precursor acute lymphoblastic leukaemia

Zhang, J., Ding, L., Holmfeldt, L., Wu, G., Heatley, S. L., Payne-Turner, D., Easton, J., Chen, X., Wang, J., Rusch, M., et al. (2012) · Nature

Acute Lymphoblastic Leukemia researchAcute Myeloid Leukemia Research

Cited by 1,596

Tumor Suppression at the Mouse INK4a Locus Mediated by the Alternative Reading Frame Product p19

Kamijo, T., Zindy, F., Roussel, M. F., Quelle, D. E., Downing, J. R., Ashmun, R. A., Grosveld, G., & Sherr, C. J. (1997) · Cell

Cancer-related Molecular PathwaysTelomeres, Telomerase, and Senescence

Cited by 1,566

Deletion of IKZF1 and Prognosis in Acute Lymphoblastic Leukemia

Mullighan, C. G., Su, X., Zhang, J., Radtke, I., Phillips, L. A. A., Miller, C. B., Ma, J., Liu, W., Cheng, C., Schulman, B. A., et al. (2009) · New England Journal of Medicine

Acute Lymphoblastic Leukemia researchLymphoma Diagnosis and Treatment

Cited by 1,422

Germline Mutations in Predisposition Genes in Pediatric Cancer

Zhang, J., Walsh, M. F., Wu, G., Edmonson, M. N., Gruber, T. A., Easton, J., Hedges, D., Ma, X., Zhou, X., Yergeau, D. A., et al. (2015) · New England Journal of Medicine

BRCA gene mutations in cancerCancer Genomics and Diagnostics

Cited by 1,345

Treating Childhood Acute Lymphoblastic Leukemia without Cranial Irradiation

Pui, C.-H., Campana, D., Pei, D., Bowman, W. P., Sandlund, J. T., Kaste, S. C., Ribeiro, R. C., Rubnitz, J. E., Raimondi, S. C., Onciu, M., et al. (2009) · New England Journal of Medicine

Acute Lymphoblastic Leukemia researchCNS Lymphoma Diagnosis and Treatment

Cited by 1,215

BCR–ABL1 lymphoblastic leukaemia is characterized by the deletion of Ikaros

Mullighan, C. G., Miller, C. B., Radtke, I., Phillips, L. A., Dalton, J., Ma, J., White, D., Hughes, T. P., Le Beau, M. M., Pui, C.-H., et al. (2008) · Nature

Acute Lymphoblastic Leukemia researchChronic Myeloid Leukemia Treatments

Cited by 1,072

The genomic landscape of pediatric and young adult T-lineage acute lymphoblastic leukemia

Liu, Y., Easton, J., Shao, Y., Maciaszek, J., Wang, Z., Wilkinson, M. R., McCastlain, K., Edmonson, M., Pounds, S. B., Shi, L., et al. (2017) · Nature Genetics

Acute Lymphoblastic Leukemia researchAcute Myeloid Leukemia Research

Cited by 918

Recurrent Somatic Structural Variations Contribute to Tumorigenesis in Pediatric Osteosarcoma

Chen, X., Bahrami, A., Pappo, A., Easton, J., Dalton, J., Hedlund, E., Ellison, D., Shurtleff, S., Wu, G., Wei, L., et al. (2014) · Cell Reports

Sarcoma Diagnosis and TreatmentCancer Genomics and Diagnostics

Cited by 752

Bethesda proposals for classification of nonlymphoid hematopoietic neoplasms in mice

Kogan, S. C., Ward, J. M., Anver, M. R., Berman, J. J., Brayton, C., Cardiff, R. D., Carter, J. S., de Coronado, S., Downing, J. R., Fredrickson, T. N., et al. (2002) · Blood

Acute Myeloid Leukemia ResearchVeterinary Oncology Research

Cited by 418

Orthotopic patient-derived xenografts of paediatric solid tumours

Stewart, E., Federico, S. M., Chen, X., Shelat, A. A., Bradley, C., Gordon, B., Karlstrom, A., Twarog, N. R., Clay, M. R., Bahrami, A., et al. (2017) · Nature

Cancer Genomics and DiagnosticsCancer Cells and Metastasis

Cited by 286

The t(12;21) Translocation Converts AML-1B from an Activator to a Repressor of Transcription

Hiebert, S. W., Sun, W., Nathan Davis, J., Golub, T., Shurtleff, S., Buijs, A., Downing, J. R., Grosveld, G., Roussel, M. F., Gary Gilliland, D., et al. (1996) · Molecular and Cellular Biology

Acute Lymphoblastic Leukemia researchGenomics and Chromatin Dynamics

Cited by 272

The t(8;21) Fusion Product, AML-1–ETO, Associates with C/EBP-α, Inhibits C/EBP-α-Dependent Transcription, and Blocks Granulocytic Differentiation

Westendorf, J. J., Yamamoto, C. M., Lenny, N., Downing, J. R., Selsted, M. E., & Hiebert, S. W. (1998) · Molecular and Cellular Biology

Acute Myeloid Leukemia ResearchRetinoids in leukemia and cellular processes

Cited by 270

Both TEL and AML-1 Contribute Repression Domains to the t(12;21) Fusion Protein

Fenrick, R., Amann, J. M., Lutterbach, B., Wang, L., Westendorf, J. J., Downing, J. R., & Hiebert, S. W. (1999) · Molecular and Cellular Biology

Acute Lymphoblastic Leukemia researchGenomics and Chromatin Dynamics

Cited by 162

Identification of Therapeutic Targets in Rhabdomyosarcoma through Integrated Genomic, Epigenomic, and Proteomic Analyses

Stewart, E., McEvoy, J., Wang, H., Chen, X., Honnell, V., Ocarz, M., Gordon, B., Dapper, J., Blankenship, K., Yang, Y., et al. (2018) · Cancer Cell

Sarcoma Diagnosis and TreatmentChromatin Remodeling and Cancer

Cited by 153

Somatic deletions of genes regulating MSH2 protein stability cause DNA mismatch repair deficiency and drug resistance in human leukemia cells

Diouf, B., Cheng, Q., Krynetskaia, N. F., Yang, W., Cheok, M., Pei, D., Fan, Y., Cheng, C., Krynetskiy, E. Y., Geng, H., et al. (2011) · Nature Medicine

DNA Repair MechanismsAcute Lymphoblastic Leukemia research

Cited by 129

Haploinsufficiency of AML1 results in a decrease in the number of LTR-HSCs while simultaneously inducing an increase in more mature progenitors.

Sun, W., & Downing, J. R. (2004) · Blood

Hematopoietic Stem Cell TransplantationAcute Myeloid Leukemia Research

Cited by 118

Identification of AML-1 and the (8;21) Translocation Protein (AML-1/ETO) as Sequence-Specific DNA-Binding Proteins: the runt Homology Domain is Required for DNA Binding and Protein-Protein Interactions

Meyers, S., Downing, J. R., & Hiebert, S. W. (1993) · Molecular and Cellular Biology

Acute Myeloid Leukemia ResearchRetinoids in leukemia and cellular processes

Cited by 94

The Wave2 scaffold Hem-1 is required for transition of fetal liver hematopoiesis to bone marrow

Shao, L., Chang, J., Feng, W., Wang, X., Williamson, E. A., Li, Y., Schajnovitz, A., Scadden, D., Mortensen, L. J., Lin, C. P., et al. (2018) · Nature Communications

Hematopoietic Stem Cell TransplantationBlood disorders and treatments

Cited by 20