Kaufman, Randal J.

Mechanisms, regulation and functions of the unfolded protein response

Hetz, C., Zhang, K., & Kaufman, R. J. (2020) · Nature Reviews Molecular Cell Biology

Endoplasmic Reticulum Stress and DiseaseHeat shock proteins research

Cited by 2,666

From endoplasmic-reticulum stress to the inflammatory response

Zhang, K., & Kaufman, R. J. (2008) · Nature

Endoplasmic Reticulum Stress and DiseaseIon Channels and Receptors

Cited by 2,010

ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death

Han, J., Back, S. H., Hur, J., Lin, Y.-H., Gildersleeve, R., Shan, J., Yuan, C. L., Krokowski, D., Wang, S., Hatzoglou, M., et al. (2013) · Nature Cell Biology

Endoplasmic Reticulum Stress and DiseaseHeat shock proteins research

Cited by 1,691

Protein misfolding in the endoplasmic reticulum as a conduit to human disease

Wang, M., & Kaufman, R. J. (2016) · Nature

Endoplasmic Reticulum Stress and DiseaseHeat shock proteins research

Cited by 1,630

Orchestrating the unfolded protein response in health and disease

Kaufman, R. J. (2002) · Journal of Clinical Investigation

Endoplasmic Reticulum Stress and DiseaseIon Channels and Receptors

Cited by 1,015

ER stress (PERK/eIF2α phosphorylation) mediates the polyglutamine-induced LC3 conversion, an essential step for autophagy formation

Kouroku, Y., Fujita, E., Tanida, I., Ueno, T., Isoai, A., Kumagai, H., Ogawa, S., Kaufman, R. J., Kominami, E., & Momoi, T. (2007) · Cell Death & Differentiation

Genetic Neurodegenerative DiseasesAutophagy in Disease and Therapy

Cited by 934

Endoplasmic Reticulum Chaperone Protein GRP78 Protects Cells from Apoptosis Induced by Topoisomerase Inhibitors

Reddy, R. K., Mao, C., Baumeister, P., Austin, R. C., Kaufman, R. J., & Lee, A. S. (2003) · Journal of Biological Chemistry

Endoplasmic Reticulum Stress and DiseaseCell death mechanisms and regulation

Cited by 695

ER Stress Cooperates with Hypernutrition to Trigger TNF-Dependent Spontaneous HCC Development

Nakagawa, H., Umemura, A., Taniguchi, K., Font-Burgada, J., Dhar, D., Ogata, H., Zhong, Z., Valasek, M. A., Seki, E., Hidalgo, J., et al. (2014) · Cancer Cell

Endoplasmic Reticulum Stress and DiseaseCancer, Lipids, and Metabolism

Cited by 525

Phosphorylation of Eukaryotic Translation Initiation Factor 2 Mediates Apoptosis in Response to Activation of the Double-stranded RNA-dependent Protein Kinase

Srivastava, S. P., Kumar, K. U., & Kaufman, R. J. (1998) · Journal of Biological Chemistry

Endoplasmic Reticulum Stress and DiseaseCell death mechanisms and regulation

Cited by 378

Anti-oncogenic role of the endoplasmic reticulum differentially activated by mutations in the MAPK pathway

Denoyelle, C., Abou-Rjaily, G., Bezrookove, V., Verhaegen, M., Johnson, T. M., Fullen, D. R., Pointer, J. N., Gruber, S. B., Su, L. D., Nikiforov, M. A., et al. (2006) · Nature Cell Biology

Endoplasmic Reticulum Stress and DiseaseMelanoma and MAPK Pathways

Cited by 349

ER Stress Drives Lipogenesis and Steatohepatitis via Caspase-2 Activation of S1P

Kim, J. Y., Garcia-Carbonell, R., Yamachika, S., Zhao, P., Dhar, D., Loomba, R., Kaufman, R. J., Saltiel, A. R., & Karin, M. (2018) · Cell

Liver Disease Diagnosis and TreatmentEndoplasmic Reticulum Stress and Disease

Cited by 333

The Unfolded Protein Response Mediates Adaptation to Exercise in Skeletal Muscle through a PGC-1α/ATF6α Complex

Wu, J., Ruas, J. L., Estall, J. L., Rasbach, K. A., Choi, J. H., Ye, L., Boström, P., Tyra, H. M., Crawford, R. W., Campbell, K. P., et al. (2011) · Cell Metabolism

Endoplasmic Reticulum Stress and DiseaseMuscle Physiology and Disorders

Cited by 312

The amino acid sensor GCN2 controls gut inflammation by inhibiting inflammasome activation

Ravindran, R., Loebbermann, J., Nakaya, H. I., Khan, N., Ma, H., Gama, L., Machiah, D. K., Lawson, B., Hakimpour, P., Wang, Y.-C., et al. (2016) · Nature

Inflammatory Bowel DiseaseInflammasome and immune disorders

Cited by 312

ER Stress Controls Iron Metabolism Through Induction of Hepcidin

Vecchi, C., Montosi, G., Zhang, K., Lamberti, I., Duncan, S. A., Kaufman, R. J., & Pietrangelo, A. (2009) · Science

Iron Metabolism and DisordersEndoplasmic Reticulum Stress and Disease

Cited by 310

Bleeding due to disruption of a cargo-specific ER-to-Golgi transport complex

Zhang, B., Cunningham, M. A., Nichols, W. C., Bernat, J. A., Seligsohn, U., Pipe, S. W., McVey, J. H., Schulte-Overberg, U., de Bosch, N. B., Ruiz-Saez, A., et al. (2003) · Nature Genetics

Cellular transport and secretionHemophilia Treatment and Research

Cited by 309

Ppp1r15 gene knockout reveals an essential role for translation initiation factor 2 alpha (eIF2α) dephosphorylation in mammalian development

Harding, H. P., Zhang, Y., Scheuner, D., Chen, J.-J., Kaufman, R. J., & Ron, D. (2009) · Proceedings of the National Academy of Sciences

Endoplasmic Reticulum Stress and DiseaseRNA and protein synthesis mechanisms

Cited by 267

Senescence-associated secretory phenotype contributes to pathological angiogenesis in retinopathy

Oubaha, M., Miloudi, K., Dejda, A., Guber, V., Mawambo, G., Germain, M.-A., Bourdel, G., Popovic, N., Rezende, F. A., Kaufman, R. J., et al. (2016) · Science Translational Medicine

Telomeres, Telomerase, and SenescenceRetinal Diseases and Treatments

Cited by 259

Gut microbiota dependent anti-tumor immunity restricts melanoma growth in Rnf5−/− mice

Li, Y., Tinoco, R., Elmén, L., Segota, I., Xian, Y., Fujita, Y., Sahu, A., Zarecki, R., Marie, K., Feng, Y., et al. (2019) · Nature Communications

Gut microbiota and healthCancer Immunotherapy and Biomarkers

Cited by 212

Protein Folding in the Endoplasmic Reticulum and the Unfolded Protein Response

Zhang, K., & Kaufman, R. J. (2005) · Handbook of Experimental Pharmacology

Endoplasmic Reticulum Stress and DiseaseHeat shock proteins research

Cited by 152

Adaptation of endoplasmic reticulum exit sites to acute and chronic increases in cargo load

Farhan, H., Weiss, M., Tani, K., Kaufman, R. J., & Hauri, H. (2008) · The EMBO Journal

Cellular transport and secretionEndoplasmic Reticulum Stress and Disease

Cited by 138

Identification of the components necessary for adenovirus translational control and their utilization in cDNA expression vectors

Kaufman, R. J. (1985) · Proceedings of the National Academy of Sciences

RNA and protein synthesis mechanismsRNA Research and Splicing

Cited by 135

Integrated Stress Response Modulates Cellular Redox State via Induction of Cystathionine γ-Lyase

Dickhout, J. G., Carlisle, R. E., Jerome, D. E., Mohammed-Ali, Z., Jiang, H., Yang, G., Mani, S., Garg, S. K., Banerjee, R., Kaufman, R. J., et al. (2012) · Journal of Biological Chemistry

Endoplasmic Reticulum Stress and DiseaseSulfur Compounds in Biology

Cited by 129

Persistent Glycoprotein Misfolding Activates the Glucosidase II/UGT1-Driven Calnexin Cycle to Delay Aggregation and Loss of Folding Competence

Molinari, M., Galli, C., Vanoni, O., Arnold, S. M., & Kaufman, R. J. (2005) · Molecular Cell

Endoplasmic Reticulum Stress and DiseaseHeat shock proteins research

Cited by 121

In vitro and in vivo functional characterization of bovine vitamin K-dependent gamma-carboxylase expressed in Chinese hamster ovary cells

Rehemtulla, A., Roth, D. A., Wasley, L. C., Kuliopulos, A., Walsh, C. T., Furie, B., Furie, B. C., & Kaufman, R. J. (1993) · Proceedings of the National Academy of Sciences

Hemophilia Treatment and ResearchViral Infectious Diseases and Gene Expression in Insects

Cited by 70