Liu, Jun O.

Genetic and pharmacological disruption of the TEAD–YAP complex suppresses the oncogenic activity of YAP

Liu-Chittenden, Y., Huang, B., Shim, J. S., Chen, Q., Lee, S.-J., Anders, R. A., Liu, J. O., & Pan, D. (2012) · Genes & Development

Hippo pathway signaling and YAP/TAZCancer-related molecular mechanisms research

Cited by 1,452

Digoxin and other cardiac glycosides inhibit HIF-1α synthesis and block tumor growth

Zhang, H., Qian, D. Z., Tan, Y. S., Lee, K., Gao, P., Ren, Y. R., Rey, S., Hammers, H., Chang, D., Pili, R., et al. (2008) · Proceedings of the National Academy of Sciences

Cancer, Hypoxia, and MetabolismAngiogenesis and VEGF in Cancer

Cited by 624

Itraconazole, a Commonly Used Antifungal that Inhibits Hedgehog Pathway Activity and Cancer Growth

Kim, J., Tang, J. Y., Gong, R., Kim, J., Lee, J. J., Clemons, K. V., Chong, C. R., Chang, K. S., Fereshteh, M., Gardner, D., et al. (2010) · Cancer Cell

Hedgehog Signaling Pathway StudiesHippo pathway signaling and YAP/TAZ

Cited by 527

RETRACTED: Acriflavine inhibits HIF-1 dimerization, tumor growth, and vascularization

Lee, K., Zhang, H., Qian, D. Z., Rey, S., Liu, J. O., & Semenza, G. L. (2009) · Proceedings of the National Academy of Sciences

Cancer, Hypoxia, and MetabolismAngiogenesis and VEGF in Cancer

Cited by 451

Recent Advances in Drug Repositioning for the Discovery of New Anticancer Drugs

Shim, J. S., & Liu, J. O. (2014) · International Journal of Biological Sciences

Computational Drug Discovery MethodsCancer Mechanisms and Therapy

Cited by 382

RETRACTED: Anthracycline chemotherapy inhibits HIF-1 transcriptional activity and tumor-induced mobilization of circulating angiogenic cells

Lee, K., Qian, D. Z., Rey, S., Wei, H., Liu, J. O., & Semenza, G. L. (2009) · Proceedings of the National Academy of Sciences

Cancer, Hypoxia, and MetabolismAngiogenesis and VEGF in Cancer

Cited by 289

Post-translational Modifications of Three Members of the Human MAP1LC3 Family and Detection of a Novel Type of Modification for MAP1LC3B

He, H., Dang, Y., Dai, F., Guo, Z., Wu, J., She, X., Pei, Y., Chen, Y., Ling, W., Wu, C., et al. (2003) · Journal of Biological Chemistry

Autophagy in Disease and TherapyUbiquitin and proteasome pathways

Cited by 273

Inhibition of Angiogenesis by the Antifungal Drug Itraconazole

Chong, C. R., Xu, J., Lu, J., Bhat, S., Sullivan, D. J., & Liu, J. O. (2007) · ACS Chemical Biology

Angiogenesis and VEGF in CancerHeterocyclic Compound Synthesis and Bioactivity

Cited by 210

Cholesterol trafficking is required for mTOR activation in endothelial cells

Xu, J., Dang, Y., Ren, Y. R., & Liu, J. O. (2010) · Proceedings of the National Academy of Sciences

PI3K/AKT/mTOR signaling in cancerCholesterol and Lipid Metabolism

Cited by 209

Itraconazole Inhibits Angiogenesis and Tumor Growth in Non–Small Cell Lung Cancer

Aftab, B. T., Dobromilskaya, I., Liu, J. O., & Rudin, C. M. (2011) · Cancer Research

Angiogenesis and VEGF in CancerCancer, Hypoxia, and Metabolism

Cited by 167

Rapamycin-inspired macrocycles with new target specificity

Guo, Z., Hong, S. Y., Wang, J., Rehan, S., Liu, W., Peng, H., Das, M., Li, W., Bhat, S., Peiffer, B., et al. (2019) · Nature Chemistry

Chemical Synthesis and AnalysisSupramolecular Chemistry and Complexes

Cited by 120

Antifungal drug itraconazole targets VDAC1 to modulate the AMPK/mTOR signaling axis in endothelial cells

Head, S. A., Shi, W., Zhao, L., Gorshkov, K., Pasunooti, K., Chen, Y., Deng, Z., Li, R.-J., Shim, J. S., Tan, W., et al. (2015) · Proceedings of the National Academy of Sciences

PI3K/AKT/mTOR signaling in cancerAngiogenesis and VEGF in Cancer

Cited by 111

Total synthesis of the cyclodepsipeptide apratoxin A and its analogues and assessment of their biological activities

Ma, D., Zou, B., Cai, G., Hu, X., & Liu, J. O. (2006) · Chemistry – A European Journal

Chemical Synthesis and AnalysisAdvanced Synthetic Organic Chemistry

Cited by 99

Simultaneous Targeting of NPC1 and VDAC1 by Itraconazole Leads to Synergistic Inhibition of mTOR Signaling and Angiogenesis

Head, S. A., Shi, W. Q., Yang, E. J., Nacev, B. A., Hong, S. Y., Pasunooti, K. K., Li, R.-J., Shim, J. S., & Liu, J. O. (2017) · ACS Chemical Biology

PI3K/AKT/mTOR signaling in cancerCancer, Lipids, and Metabolism

Cited by 82

Binding and regulation of the transcription factor NFAT by the peptidyl prolyl cis–trans isomerase Pin1

Liu, W., Youn, H.-D., Zhou, X. Z., Lu, K. P., & Liu, J. O. (2001) · FEBS Letters

Signaling Pathways in DiseaseProtein Structure and Dynamics

Cited by 52

Novel Tetrazole-Containing Analogues of Itraconazole as Potent Antiangiogenic Agents with Reduced Cytochrome P450 3A4 Inhibition

Li, Y., Pasunooti, K. K., Li, R.-J., Liu, W., Head, S. A., Shi, W. Q., & Liu, J. O. (2018) · Journal of Medicinal Chemistry

Synthesis of Tetrazole DerivativesHeterocyclic Compound Synthesis and Bioactivity

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Daily administration of low-dose daunorubicin or doxorubicin inhibits hypoxia-inducible factor 1 and tumor vascularization

Yang, Y., Qian, D. Z., Rey, S., Liu, J. O., & Semenza, G. L. (2022) · bioRxiv (Cold Spring Harbor Laboratory)

Cancer, Hypoxia, and MetabolismAngiogenesis and VEGF in Cancer

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