Itraconazole, a Commonly Used Antifungal that Inhibits Hedgehog Pathway Activity and Cancer Growth
Open accessAbstract
In a screen of drugs previously tested in humans we identified itraconazole, a systemic antifungal, as a potent antagonist of the Hedgehog (Hh) signaling pathway that acts by a mechanism distinct from its inhibitory effect on fungal sterol biosynthesis. Systemically administered itraconazole, like other Hh pathway antagonists, can suppress Hh pathway activity and the growth of medulloblastoma in a mouse allograft model and does so at serum levels comparable to those in patients undergoing antifungal therapy. Mechanistically, itraconazole appears to act on the essential Hh pathway component Smoothened (SMO) by a mechanism distinct from that of cyclopamine and other known SMO antagonists, and prevents the ciliary accumulation of SMO normally caused by Hh stimulation.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
The price of innovation: new estimates of drug development costs
DiMasi, J. A., Hansen, R. W., & Grabowski, H. G. (2003) · Journal of Health Economics · doi:10.1016/s0167-6296(02)00126-1 · Cited by 4,265 · see citing works
Altered Neural Cell Fates and Medulloblastoma in Mouse <i>patched</i> Mutants
Goodrich, L. V., Milenković, L., Higgins, K. M., & Scott, M. P. (1997) · Science · doi:10.1126/science.277.5329.1109 · Cited by 1,696 · see citing works
Vertebrate Smoothened functions at the primary cilium
Corbit, K. C., Aanstad, P., Singla, V., Norman, A. R., Stainier, D. Y. R., & Reiter, J. F. (2005) · Nature · doi:10.1038/nature04117 · Cited by 1,481 · see citing works
Inhibition of Hedgehog signaling by direct binding of cyclopamine to SmoothenedPreprint
Chen, J., Taipale, J., Cooper, M. K., & Beachy, P. A. (2002) · Genes & Development · doi:10.1101/gad.1025302 · Cited by 1,464 · see citing works
Self-citationPatched1 Regulates Hedgehog Signaling at the Primary Cilium
Rohatgi, R., Milenkovic, L., & Scott, M. P. (2007) · Science · doi:10.1126/science.1139740 · Cited by 1,426 · see citing works
The Hedgehog and Wnt signalling pathways in cancer
Taipale, J., & Beachy, P. A. (2001) · Nature · doi:10.1038/35077219 · Cited by 1,392 · see citing works
Self-citationActivating Smoothened mutations in sporadic basal-cell carcinoma
Xie, J., Murone, M., Luoh, S.-M., Ryan, A. M., Gu, Q., Zhang, C., Bonifas, J. M., Lam, C.-W., Hynes, M., Goddard, A. D., et al. (1998) · Nature · doi:10.1038/34201 · Cited by 1,333 · see citing works
Self-citationEffects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine
Taipale, J., Chen, J., Cooper, M. K., Wang, B., Mann, R. K., Milenković, L., Scott, M. P., & Beachy, P. A. (2000) · Nature · doi:10.1038/35023008 · Cited by 1,314 · see citing works
Self-citationHedgehog: functions and mechanisms
Varjosalo, M., & Taipale, J. (2008) · Genes & Development · doi:10.1101/gad.1693608 · Cited by 1,217 · see citing works
Tissue repair and stem cell renewal in carcinogenesis
Beachy, P. A., Karhadkar, S. S., & Berman, D. M. (2004) · Nature · doi:10.1038/nature03100 · Cited by 1,194 · see citing works
Self-citationInhibition of the Hedgehog Pathway in Advanced Basal-Cell Carcinoma
Hoff, D. D. V., LoRusso, P. M., Rudin, C. M., Reddy, J. C., Yauch, R. L., Tibes, R., Weiss, G. J., Borad, M. J., Hann, C. L., Brahmer, J. R., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0905360 · Cited by 1,109 · see citing works
Jonkers, J., Meuwissen, R. L. J., van der Gulden, H. M. L., Peterse, H. L., van der Valk, M., & Berns, A. J. M. (2001) · Nature Genetics · doi:10.1038/ng747 · Cited by 1,053 · see citing works
Treatment of Medulloblastoma with Hedgehog Pathway Inhibitor GDC-0449
Rudin, C. M., Hann, C. L., Laterra, J., Yauch, R. L., Callahan, C. A., Fu, L., Holcomb, T., Stinson, J., Gould, S. E., Coleman, B., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0902903 · Cited by 1,017 · see citing works
Small molecule modulation of Smoothened activity
Chen, J., Taipale, J., Young, K. E., Maiti, T., & Beachy, P. A. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.182542899 · Cited by 991 · see citing works
Self-citationA paracrine requirement for hedgehog signalling in cancer
Yauch, R. L., Gould, S. E., Scales, S. J., Tang, T. T.-L., Tian, H., Ahn, C. P., Marshall, D. C. L., Fu, L., Januario, T., Kallop, D. Y., et al. (2008) · Nature · doi:10.1038/nature07275 · Cited by 961 · see citing works
Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia
Zhao, C., Chen, A., Jamieson, C. H. M., Fereshteh, M., Abrahamsson, A. E., Blum, J. M., Kwon, H. Y., Kim, J., Chute, J. P., Rizzieri, D. A., et al. (2009) · Nature · doi:10.1038/nature07737 · Cited by 868 · see citing works
Self-citationTeratogen-Mediated Inhibition of Target Tissue Response to <i>Shh</i> Signaling
Cooper, M. K., Porter, J. A., Young, K. E., & Beachy, P. A. (1998) · Science · doi:10.1126/science.280.5369.1603 · Cited by 848 · see citing works
Self-citationMedulloblastoma Growth Inhibition by Hedgehog Pathway Blockade
Berman, D. M., Karhadkar, S. S., Hallahan, A. R., Pritchard, J. I., Eberhart, C. G., Watkins, D. N., Chen, J., Cooper, M. K., Taipale, J., Olson, J. M., et al. (2002) · Science · doi:10.1126/science.1073733 · Cited by 802 · see citing works
Self-citationFeldmann, G., Dhara, S., Fendrich, V., Bedja, D., Beaty, R. M., Mullendore, M. E., Karikari, C. A., Alvarez, H., Iacobuzio–Donahue, C. A., Jimeno, A., et al. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-3281 · Cited by 685 · see citing works
The teratogenic Veratrum alkaloid cyclopamine inhibits Sonic hedgehog signal transduction
Incardona, J. P., Gaffield, W., Kapur, R. P., & Roelink, H. (1998) · Development · doi:10.1242/dev.125.18.3553 · Cited by 657 · see citing works
Principles of Drug Action: The Basis of Pharmacology.
D, A. G. M., Aronow, L., Kalman, S. M., & Kalman, S. M. (1975) · Annals of Internal Medicine · doi:10.7326/0003-4819-82-1-130_2 · Cited by 613 · see citing works
Costa, T., & Herz, A. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.19.7321 · Cited by 537 · see citing works
Romer, J. T., Kimura, H., Magdaleno, S. M., Sasai, K., Fuller, C. E., Baines, H., Connelly, M., Stewart, C. F., Gould, S. E., Rubin, L. L., et al. (2004) · Cancer Cell · doi:10.1016/j.ccr.2004.08.019 · Cited by 521 · see citing works
Expansion of Bcr-Abl-Positive Leukemic Stem Cells Is Dependent on Hedgehog Pathway Activation
Dierks, C., Beigi, R., Guo, G.-R., et al. (2008) · Cancer Cell · doi:10.1016/j.ccr.2008.08.003 · Cited by 516 · see citing works
Antifungal agents: chemotherapeutic targets and immunologic strategies
Georgopapadakou, N. H., & Walsh, T. J. (1996) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.40.2.279 · Cited by 495 · see citing works
Frank-Kamenetsky, M. D., Zhang, X. M., Bottega, S., Guicherit, O. M., Wichterle, H., Dudek, H., Bumcrot, D. A., Wang, F. Y., Jones, S. S., Shulok, J. R., et al. (2002) · Journal of Biology · doi:10.1186/1475-4924-1-10 · Cited by 488 · see citing works
Sterol 14α-demethylase cytochrome P450 (CYP51), a P450 in all biological kingdoms
Lepesheva, G. I., & Waterman, M. R. (2006) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2006.07.018 · Cited by 476 · see citing works
Bond, R. A., Leff, P., Johnson, T. D., et al. (1995) · Nature · doi:10.1038/374272a0 · Cited by 421 · see citing works
A defective response to Hedgehog signaling in disorders of cholesterol biosynthesis
Cooper, M. K., Wassif, C. A., Krakowiak, P. A., Taipale, J., Gong, R., Kelley, R. I., Porter, F. D., & Beachy, P. A. (2003) · Nature Genetics · doi:10.1038/ng1134 · Cited by 390 · see citing works
Self-citationTHE MAMMALIAN LOW-DENSITY LIPOPROTEIN RECEPTOR FAMILY
Hussain, M. M., Strickland, D. K., & Bakillah, A. (1999) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.19.1.141 · Cited by 376 · see citing works
Kim, J., Kato, M., & Beachy, P. A. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0912180106 · Cited by 347 · see citing works
Self-citationWnt-mediated self-renewal of neural stem/progenitor cells
Kalani, M. Y. S., Cheshier, S. H., Cord, B. J., Bababeygy, S. R., Vogel, H. S., Weissman, I. L., Palmer, T. D., & Nusse, R. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0808616105 · Cited by 333 · see citing works
Oxysterols stimulate Sonic hedgehog signal transduction and proliferation of medulloblastoma cells
Corcoran, R. B., & Scott, M. P. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0602852103 · Cited by 314 · see citing works
Oxysterols Are Novel Activators of the Hedgehog Signaling Pathway in Pluripotent Mesenchymal Cells
Dwyer, J. R., Sever, N., Carlson, M. R. J., Nelson, S. F., Beachy, P. A., & Parhami, F. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m611741200 · Cited by 300 · see citing works
Self-citationA clinical drug library screen identifies astemizole as an antimalarial agent
Chong, C. R., Chen, X., Shi, L., Liu, J. O., & Sullivan, D. J. (2006) · Nature Chemical Biology · doi:10.1038/nchembio806 · Cited by 291 · see citing works
Self-citationHedgehog signal transduction by Smoothened: Pharmacologic evidence for a 2-step activation process
Rohatgi, R., Milenković, L., Corcoran, R. B., & Scott, M. P. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0813373106 · Cited by 280 · see citing works
Barone, J. A., Koh, J.-S., Bierman, R. H., Colaizzi, J. L., Swanson, K. A., Gaffar, M. C., Moskovitz, B. L., Mechlinski, W., & de Velde, V. V. (1993) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.37.4.778 · Cited by 226 · see citing works
Megalin Functions as an Endocytic Sonic Hedgehog Receptor
McCarthy, R. A., Barth, J. L., Chintalapudi, M. R., Knaak, C., & Argraves, W. S. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m201933200 · Cited by 209 · see citing works
Wang, Y., Zhou, Z., Walsh, C. T., & McMahon, A. P. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0812110106 · Cited by 199 · see citing works
Principles of Drug Action. The Basis of Pharmacology
Lennard, L. (1991) · Journal of Clinical Pathology · doi:10.1136/jcp.44.1.88-a · Cited by 165 · see citing works
High-dose itraconazole in the treatment of severe mycoses
Sharkey, P. K., Rinaldi, M. G., Dunn, J. F., Hardin, T. C., Fetchick, R. J., & Graybill, J. R. (1991) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.35.4.707 · Cited by 155 · see citing works
The use of fluconazole and itraconazole in the treatment of Candida albicans infections: a review
Martin, M. V. (1999) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/44.4.429 · Cited by 149 · see citing works
Effect of cyclodextrin on the pharmacology of antifungal oral azoles
Hostetler, J. S., Hanson, L. H., & Stevens, D. A. (1992) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.36.2.477 · Cited by 141 · see citing works
Self-citationPharmacology and toxicity of high-dose ketoconazole
Sugar, A. M., Alsip, S. G., Galgiani, J. N., Graybill, J. R., Dismukes, W. E., Cloud, G. A., Craven, P. C., & Stevens, D. A. (1987) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.31.12.1874 · Cited by 129 · see citing works
Self-citationNew estimates of drug development costs
Frank, R. G. (2003) · Journal of Health Economics · doi:10.1016/s0167-6296(03)00002-x · Cited by 115 · see citing works
Molecular mechanisms of Sonic hedgehog mutant effects in holoprosencephaly
Maity, T. K., Fuse, N., & Beachy, P. A. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0507848102 · Cited by 106 · see citing works
Self-citationThe role of megalin (LRP-2/Gp330) during development
Fisher, C. E., & Howie, S. (2006) · Developmental Biology · doi:10.1016/j.ydbio.2006.06.007 · Cited by 102 · see citing works
Emergence of Methicillin-Resistant Staphylococcus aureus with Intermediate Glycopeptide Resistance
Rybak, M. J., & Akins, R. L. (2001) · Drugs · doi:10.2165/00003495-200161010-00001 · Cited by 101 · see citing works
Trösken, E. R., Adamska, M., Arand, M., Zarn, J. A., Patten, C., Völkel, W., & Lutz, W. K. (2006) · Toxicology · doi:10.1016/j.tox.2006.08.007 · Cited by 95 · see citing works
Identification of Type 1 Inosine Monophosphate Dehydrogenase as an Antiangiogenic Drug Target
Chong, C. R., Qian, D. Z., Pan, F., Wei, Y., Пили, Р., Sullivan, D. J., & Liu, J. O. (2006) · Journal of Medicinal Chemistry · doi:10.1021/jm051225t · Cited by 93 · see citing works
Self-citationHostetler, J. S., Heykants, J., Clemons, K. V., et al. (1993) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.37.10.2224 · Cited by 87 · see citing works
Self-citationTrump, D. L., Havlin, K. H., Messing, E. M., Cummings, K. B., Lange, P. H., & Jordan, V. C. (1989) · Journal of Clinical Oncology · doi:10.1200/jco.1989.7.8.1093 · Cited by 83 · see citing works
Clemons, K. V., Sobel, R. A., Williams, P. L., Pappagianis, D., & Stevens, D. A. (2002) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.46.8.2420-2426.2002 · Cited by 78 · see citing works
Self-citationRecent patents for Hedgehog pathway inhibitors for the treatment of malignancy
Tremblay, M. R., Nesler, M., Weatherhead, R., & Castro, A. C. (2009) · Expert Opinion on Therapeutic Patents · doi:10.1517/13543770903008551 · Cited by 76 · see citing works
Benzo(a)pyrene uptake by human plasma lipoproteins in vitro.
Shu, H. P., & Nichols, A. V. (1979) · PubMed · Cited by 69 · see citing works
Treatment of Cerebral Aspergillosis with Itraconazole: Do High Doses Improve the Prognosis?
Sanchez, C., Mauri, E., Dalman, D., Quintana, S., Aparicio, A., & Garau, J. (1995) · Clinical Infectious Diseases · doi:10.1093/clinids/21.6.1485 · Cited by 61 · see citing works
So, P.-L., Lee, K. M. L., Hebert, J. L., Walker, P., Lü, Y., Hwang, J., Kopelovich, L., Athar, M., Bickers, D. R., Aszterbaum, M., et al. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-1927 · Cited by 57 · see citing works
Self-citationFollowing the Hedgehog to New Cancer Therapies
Dlugosz, A. A., & Talpaz, M. (2009) · New England Journal of Medicine · doi:10.1056/nejme0906092 · Cited by 56 · see citing works
Rex, J. H., Hanson, L. H., Amantea, M., et al. (1991) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.35.5.846 · Cited by 55 · see citing works
Scholz, M. C., Jennrich, R. I., Strum, S. B., et al. (2005) · The Journal of Urology · doi:10.1097/01.ju.0000158449.83022.40 · Cited by 47 · see citing works
Harvey, R. P., Isenberg, R. A., & Stevens, D. A. (1980) · Clinical Infectious Diseases · doi:10.1093/clinids/2.4.559 · Cited by 43 · see citing works
Self-citationClever, B., Schmuckli‐Maurer, J., Sigrist, M., Glassner, B. J., & Heyer, W. (1999) · Yeast · doi:10.1002/(sici)1097-0061(19990630)15:9 · Cited by 40 · see citing works
Effect of low-density lipoprotein on the incorporation of benzo(a)pyrene by cultured cells.
Remsen, J. F., & Shireman, R. B. (1981) · PubMed · Cited by 38 · see citing works
Targeted Somatic Mutagenesis in the Mouse Epidermis
Metzger, D. E., Li, M., & Chambon, P. (2004) · Humana Press eBooks · doi:10.1385/1-59259-830-7:329 · Cited by 33 · see citing works
Chen, T. C., Bradley, W. A., Gotto, A. M., et al. (1979) · FEBS Letters · doi:10.1016/0014-5793(79)80822-4 · Cited by 27 · see citing works
Effects of high-dose itraconazole treatment on lipoproteins in men
Schneider, B., Gerdsen, R., Plat, J., et al. (2007) · International Journal of Clinical Pharmacology and Therapeutics · doi:10.5414/cpp45377 · Cited by 13 · see citing works
Takagi, K., Yoshida, A., Yamauchi, T., et al. (2001) · Leukemia · doi:10.1038/sj.leu.2402209 · Cited by 11 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Metabolic Reprogramming: the Emerging Concept and Associated Therapeutic Strategies
Yoshida, G. J. (2015) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-015-0221-y · Cited by 716 · see citing works
Recent Advances in Drug Repositioning for the Discovery of New Anticancer Drugs
Shim, J. S., & Liu, J. O. (2014) · International Journal of Biological Sciences · doi:10.7150/ijbs.9224 · Cited by 382 · see citing works
Self-citationSleire, L., Førde, H. E., Netland, I. A., Leiss, L., Skeie, B. S., & Enger, P. Ø. (2017) · Pharmacological Research · doi:10.1016/j.phrs.2017.07.013 · Cited by 329 · see citing works
Oxysterols are allosteric activators of the oncoprotein Smoothened
Nachtergaele, S., Mydock, L. K., Krishnan, K., Rammohan, J., Schlesinger, P. H., Covey, D. F., & Rohatgi, R. (2012) · Nature Chemical Biology · doi:10.1038/nchembio.765 · Cited by 284 · see citing works
Kim, D. J., Kim, J., Spaunhurst, K., Montoya, J., Khodosh, R., Chandra, K., Fu, T., Gilliam, A., Molgo, M., Beachy, P. A., et al. (2014) · Journal of Clinical Oncology · doi:10.1200/jco.2013.49.9525 · Cited by 289 · see citing works
Self-citationAntonarakis, E. S., Heath, E. I., Smith, D. C., Rathkopf, D., Blackford, A. L., Danila, D. C., King, S., Frost, A., Ajiboye, A. S., Zhao, M., et al. (2013) · The Oncologist · doi:10.1634/theoncologist.2012-314 · Cited by 180 · see citing works
Liu, R., Li, J., Zhang, T., Zou, L., Chen, Y., Wang, K., Lei, Y., Yuan, K., Li, Y., Lan, J., et al. (2014) · Autophagy · doi:10.4161/auto.28912 · Cited by 178 · see citing works
The role of hedgehog signalling in skeletal health and disease
Alman, B. A. (2015) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2015.84 · Cited by 141 · see citing works
Repurposing itraconazole as an anticancer agent
Tsubamoto, H., Ueda, T., Inoue, K., Sakata, K., Shibahara, H., & Sonoda, T. (2017) · Oncology Letters · doi:10.3892/ol.2017.6325 · Cited by 107 · see citing works
Head, S. A., Shi, W. Q., Yang, E. J., Nacev, B. A., Hong, S. Y., Pasunooti, K. K., Li, R.-J., Shim, J. S., & Liu, J. O. (2017) · ACS Chemical Biology · doi:10.1021/acschembio.6b00849 · Cited by 82 · see citing works
Self-citationLiang, G., Liu, M., Wang, Q., Shen, Y., Mei, H., Li, D., & Liu, W. (2017) · Oncotarget · doi:10.18632/oncotarget.15324 · Cited by 78 · see citing works
Hu, Q., Hou, Y.-C., Huang, J., Fang, J.-Y., & Xiong, H. (2017) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-017-0526-0 · Cited by 63 · see citing works
Medulloblastoma: Molecular understanding, treatment evolution, and new developments
Liu, X., Ding, C., Tan, W., & Zhang, A. (2020) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2020.107516 · Cited by 54 · see citing works
Li, C.-L., Fang, Z.-X., Wu, Z., Hou, Y.-Y., Wu, H.-T., & Liu, J. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113616 · Cited by 46 · see citing works
Self-citationRetractedDing, J., Zhou, X.-T., Zou, H.-Y., & Wu, J. (2017) · Laboratory Investigation · doi:10.1038/labinvest.2017.34 · Cited by 42 · see citing works
Itraconazole Reverts ABCB1-Mediated Docetaxel Resistance in Prostate Cancer
Lima, T. S., Souza, L. O., Iglesias-Gato, D., Elversang, J., Jørgensen, F. S., Kallunki, T., Røder, M. A., Brasso, K., & Moreira, J. M. A. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.869461 · Cited by 26 · see citing works
Itraconazole Inhibits the Growth of Cutaneous Squamous Cell Carcinoma by Targeting HMGCS1/ACSL4 Axis
Xu, C., Zhuo, Y., Liu, Y., & Chen, H. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.828983 · Cited by 23 · see citing works
Subhadarshani, S., Athar, M., & Elmets, C. A. (2020) · Current Dermatology Reports · doi:10.1007/s13671-020-00307-0 · Cited by 21 · see citing works
Cai, J., Chen, X., You, H., Li, X., & Ji, M. (2022) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2022.129011 · Cited by 4 · see citing works
Jin, S., Liu, X., Cai, L., Yan, J., Li, L., Dong, H., Gao, Y., Zhu, X., Zhang, C., & Xu, X. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1545243 · Cited by 4 · see citing works
Marzi, M., Ghasemian, A., Ghanbariasad, A., Nournia, E., & Zarenezhad, E. (2026) · RSC Advances · doi:10.1039/d5ra09799a
- Authors
- Kim, J., Tang, J. Y., Gong, R., Kim, J., Lee, J. J., Clemons, K. V., Chong, C. R., Chang, K. S., Fereshteh, M., Gardner, D., Reya, T., Liu, J. O., Epstein, E. H., Stevens, D. A., & Beachy, P. A.
- Affiliations
- Stanford University (US)
- Howard Hughes Medical Institute (US)
- Santa Clara Valley Medical Center (US)
- Johns Hopkins University (US)
- Duke Medical Center (US)
- Poisonous Plant Research Laboratory (US)
- Corresponding author
- Beachy, Philip A.
- ORCID
- Venue
- Cancer Cell
- Publisher
- Elsevier BV
- Published
- 2010-04
- Volume
- 17
- Issue
- 4
- Pages
- 388-399
- ISSN
- 1535-6108 (ISSN-L)
- PMC
- PMC4039177
- OpenAlex
- W2166221624
- Cited by
- 527
- References
- 67
- Citations by year
- 2026: 22 · 2025: 23 · 2024: 22 · 2023: 29 · 2022: 32 · 2021: 36 · 2020: 34 · 2019: 40 · 2018: 46 · 2017: 38 · 2016: 24 · 2015: 50 · 2014: 40 · 2013: 28 · 2012: 35
- FWCI
- 11.85
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cancer Cell (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Howard Hughes Medical Institute
- Prostate Cancer Foundation
- Johns Hopkins University
- National Cancer Institute (R21CA158640)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD039306)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Hedgehog Signaling Pathway Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Hippo pathway signaling and YAP/TAZ
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
- Keywords
- itraconazole, Hedgehog signaling, Smoothened, medulloblastoma, antifungal agents, drug repurposing, cyclopamine, cancer growth inhibition
- MeSH terms
- Animals, Antifungal Agents, Antineoplastic Agents, Basal Cell Carcinoma, Cell Division, Cyclodextrins, Humans, Kinetics, Lipoproteins, LDL, Models, Molecular, Signal Transduction, Itraconazole, Mice, Hedgehog Proteins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
