Pike, Ashley C. W.

Molecular basis of agonism and antagonism in the oestrogen receptor

Brzozowski, A. M., Pike, A. C. W., Dauter, Z., Hubbard, R. E., Bonn, T., Engström, O., Öhman, L., Greene, G. L., Gustafsson, J.-Å., & Carlquist, M. (1997) · Nature

Estrogen and related hormone effectsReceptor Mechanisms and Signaling

Cited by 3,355

Estrogen receptors: how do they signal and what are their targets

Heldring, N., Pike, A., Andersson, S., Matthews, J., Cheng, G., Hartman, J., Tujague, M., Ström, A., Treuter, E., Warner, M., et al. (2007) · Physiological Reviews

Estrogen and related hormone effectsBreast Cancer Treatment Studies

Cited by 1,857

Structural basis for Cul3 protein assembly with the BTB-Kelch family of E3 ubiquitin ligases

Canning, P., Cooper, C. D. O., Krojer, T., Murray, J. W., Pike, A. C. W., Chaikuad, A., Keates, T., Thangaratnarajah, C., Hojzan, V., Marsden, B. D., et al. (2013) · Journal of Biological Chemistry

Ubiquitin and proteasome pathwaysEnzyme Structure and Function

Cited by 284

Structure of the CaMKIIδ/Calmodulin Complex Reveals the Molecular Mechanism of CaMKII Kinase Activation

Rellos, P., Pike, A. C. W., Niesen, F. H., Salah, E., Lee, W. H., von Delft, F., & Knapp, S. (2010) · PLoS Biology

Protein Kinase Regulation and GTPase SignalingNeuroscience and Neuropharmacology Research

Cited by 279

Distinct recognition modes of FXXLF and LXXLL motifs by the androgen receptor

Dubbink, H. J., Hersmus, R., Verma, C. S., van der Korput, H. A. G. M., Berrevoets, C. A., van Tol, J., Ziel-van der Made, A. C. J., Brinkmann, A. O., Pike, A. C. W., & Trapman, J. (2004) · Molecular Endocrinology

Estrogen and related hormone effectsProstate Cancer Treatment and Research

Cited by 118

Androgen receptor ligand-binding domain interaction and nuclear receptor specificity of FXXLF and LXXLL motifs as determined by L/F swapping

Dubbink, H. J., Hersmus, R., Pike, A. C. W., Molier, M., Brinkmann, A. O., Jenster, G., & Trapman, J. (2006) · Molecular Endocrinology

Prostate Cancer Treatment and ResearchEstrogen and related hormone effects

Cited by 47

Structural basis of the mechanism and inhibition of a human ceramide synthase

Pascoa, T. C., Pike, A. C. W., Tautermann, C. S., Chi, G., Traub, M., Quigley, A., Chalk, R., Štefanic, S., Thamm, S., Pautsch, A., et al. (2023) · Nature Structural & Molecular Biology

Sphingolipid Metabolism and SignalingLysosomal Storage Disorders Research

Cited by 25

Structural basis of the mechanism and inhibition of a human ceramide synthase

Pascoa, T. C., Pike, A. C. W., Tautermann, C. S., Chi, G., Traub, M., Quigley, A., Chalk, R., Štefanić, S., Thamm, S., Pautsch, A., et al. (2025) · Nature Structural & Molecular Biology

Sphingolipid Metabolism and SignalingLysosomal Storage Disorders Research

Cited by 25

Transport and inhibition of the sphingosine-1-phosphate exporter SPNS2

Sauer, D., Li, H., Pike, A., Chang, Y.-N., Prakaash, D., Gelova, Z., Stanka, J., Moreau, C., Scott, H., Wunder, F., et al. (2023) · Nature Communications

Sphingolipid Metabolism and SignalingDrug Transport and Resistance Mechanisms

Cited by 15

Amino acid and viral binding by the high-affinity Cationic Amino acid Transporter 1 (CAT1) from Mus musculus

Ye, M., Liang, Z., Zhou, D., Pike, A. C. W., Wang, S., Wang, D., Bakshi, S., Brooke, L., Williams, E. P., Elkins, J. M., et al. (2026) · Nature Communications

Amino Acid Enzymes and MetabolismEnzyme Structure and Function

Cited by 1