MacDonald, Patrick E.

A pancreatic islet-specific microRNA regulates insulin secretion

Poy, M. N., Eliasson, L., Krutzfeldt, J., Kuwajima, S., Ma, X., MacDonald, P. E., Pfeffer, S., Tuschl, T., Rajewsky, N., Rorsman, P., et al. (2004) · Nature

Pancreatic function and diabetesMicroRNA in disease regulation

Cited by 2,102

The Multiple Actions of GLP-1 on the Process of Glucose-Stimulated Insulin Secretion

MacDonald, P. E., El-kholy, W., Riedel, M. J., Salapatek, A. M. F., Light, P. E., & Wheeler, M. B. (2002) · Diabetes

Pancreatic function and diabetesDiabetes Treatment and Management

Cited by 590

The cell biology of systemic insulin function

Tokarz, V. L., MacDonald, P. E., & Klip, A. (2018) · Journal of Cell Biology

Metabolism, Diabetes, and CancerPancreatic function and diabetes

Cited by 471

Overexpression of uncoupling protein 2 inhibits glucose-stimulated insulin secretion from rat islets.

Chan, C. B., MacDonald, P. E., Saleh, M. C., Johns, D. C., Marbàn, E., & Wheeler, M. B. (1999) · Diabetes

Pancreatic function and diabetesMitochondrial Function and Pathology

Cited by 242

Isocitrate-to-SENP1 signaling amplifies insulin secretion and rescues dysfunctional β cells

Ferdaoussi, M., Dai, X., Jensen, M. V., Wang, R., Peterson, B. S., Huang, C., Ilkayeva, O., Smith, N., Miller, N., Hajmrle, C., et al. (2015) · Journal of Clinical Investigation

Pancreatic function and diabetesDiabetes Treatment and Management

Cited by 169

SSTR2 is the functionally dominant somatostatin receptor in human pancreatic β- and α-cells

Kailey, B., van de Bunt, M., Cheley, S., Johnson, P. R., MacDonald, P. E., Gloyn, A. L., Rorsman, P., & Braun, M. (2012) · American Journal of Physiology-Endocrinology and Metabolism

Pancreatic function and diabetesReceptor Mechanisms and Signaling

Cited by 164

Genetic variant effects on gene expression in human pancreatic islets and their implications for T2D

Viñuela, A., Varshney, A., van de Bunt, M., Prasad, R. B., Asplund, O., Bennett, A., Boehnke, M., Brown, A. A., Erdos, M. R., Fadista, J., et al. (2020) · Nature Communications

Genetic Associations and EpidemiologyPancreatic function and diabetes

Cited by 152

TCF1 links GIPR signaling to the control of beta cell function and survival

Campbell, J. E., Ussher, J. R., Mulvihill, E. E., Kolic, J., Baggio, L. L., Cao, X., Liu, Y., Lamont, B. J., Morii, T., Streutker, C. J., et al. (2016) · Nature Medicine

Pancreatic function and diabetesDiabetes Treatment and Management

Cited by 142

Islet cholesterol accumulation due to loss of ABCA1 leads to impaired exocytosis of insulin granules

Kruit, J. K., Wijesekara, N., Fox, J. E. M., Dai, X.-Q., Brunham, L. R., Searle, G. J., Morgan, G. P., Costin, A. J., Tang, R., Bhattacharjee, A., et al. (2011) · Diabetes

Pancreatic function and diabetesCellular transport and secretion

Cited by 113

Improvement of islet transplantation by the fusion of islet cells with functional blood vessels

Nalbach, L., Roma, L. P., Schmitt, B. M., Becker, V., Körbel, C., Wrublewsky, S., Pack, M., Später, T., Metzger, W., Menger, M. M., et al. (2021) · EMBO Molecular Medicine

Pancreatic function and diabetesTissue Engineering and Regenerative Medicine

Cited by 106

Glucagon-Like Peptide-1 Receptor Activation Antagonizes Voltage-Dependent Repolarizing K+ Currents in β-Cells

MacDonald, P. E., Salapatek, A. M. F., & Wheeler, M. B. (2002) · Diabetes

Pancreatic function and diabetesIon channel regulation and function

Cited by 103

Corelease and Differential Exit via the Fusion Pore of GABA, Serotonin, and ATP from LDCV in Rat Pancreatic β Cells

Braun, M., Wendt, A., Karanauskaite, J., Galvanovskis, J., Clark, A., MacDonald, P. E., & Rorsman, P. (2007) · The Journal of General Physiology

Pancreatic function and diabetesCellular transport and secretion

Cited by 100

Mitochondrial metabolism of pyruvate is essential for regulating glucose-stimulated insulin secretion

Patterson, J. N., Cousteils, K., Lou, J. W., Manning Fox, J. E., MacDonald, P. E., & Joseph, J. W. (2014) · Journal of Biological Chemistry

Pancreatic function and diabetesMitochondrial Function and Pathology

Cited by 98

Transplantation of Human Pancreatic Endoderm Cells Reverses Diabetes Post Transplantation in a Prevascularized Subcutaneous Site

Pepper, A. R., Pawlick, R., Bruni, A., Wink, J., Rafiei, Y., O’Gorman, D., Yan-Do, R., Gala-Lopez, B., Kin, T., MacDonald, P. E., et al. (2017) · Stem Cell Reports

Pancreatic function and diabetesDiabetes and associated disorders

Cited by 96

SUMOylation Regulates Insulin Exocytosis Downstream of Secretory Granule Docking in Rodents and Humans

Dai, X.-Q., Plummer, G., Casimir, M., Kang, Y., Hajmrle, C., Gaisano, H. Y., Manning Fox, J. E., & MacDonald, P. E. (2011) · Diabetes

Pancreatic function and diabetesCellular transport and secretion

Cited by 92

A Glycine-Insulin Autocrine Feedback Loop Enhances Insulin Secretion From Human β-Cells and Is Impaired in Type 2 Diabetes

Yan-Do, R., Duong, E., Manning Fox, J. E., Dai, X., Suzuki, K., Khan, S., Bautista, A., Ferdaoussi, M., Lyon, J., Wu, X., et al. (2016) · Diabetes

Pancreatic function and diabetesDiabetes Treatment and Management

Cited by 82

Synaptosome-Associated Protein of 25 Kilodaltons Modulates Kv2.1 Voltage-Dependent K+ Channels in Neuroendocrine Islet β-Cells through an Interaction with the Channel N Terminus

MacDonald, P. E., Wang, G., Tsuk, S., Dodo, C., Kang, Y., Tang, L., Wheeler, M. B., Cattral, M. S., Lakey, J. R. T., Salapatek, A. M. F., et al. (2002) · Molecular Endocrinology

Ion channel regulation and functionPancreatic function and diabetes

Cited by 78

Calcium increases endocytotic vesicle size and accelerates membrane fission in insulin-secreting INS-1 cells

MacDonald, P. E., Eliasson, L., & Rorsman, P. (2005) · Journal of Cell Science

Cellular transport and secretionPancreatic function and diabetes

Cited by 72

Kiss-and-run exocytosis and fusion pores of secretory vesicles in human β-cells

Hanna, S. T., Pigeau, G. M., Galvanovskis, J., Clark, A., Rorsman, P., & MacDonald, P. E. (2009) · Pflügers Archiv - European Journal of Physiology

Cellular transport and secretionPancreatic function and diabetes

Cited by 57

Characterization of Erg K+ Channels in α- and β-Cells of Mouse and Human Islets

Hardy, A. B., Fox, J. E. M., Giglou, P. R., Wijesekara, N., Bhattacharjee, A., Sultan, S., Gyulkhandanyan, A. V., Gaisano, H. Y., MacDonald, P. E., & Wheeler, M. B. (2009) · Journal of Biological Chemistry

Pancreatic function and diabetesIon channel regulation and function

Cited by 54

Autocrine activation of P2Y1 receptors couples Ca2+ influx to Ca2+ release in human pancreatic beta cells

Khan, S., Yan-Do, R., Duong, E., Wu, X., Bautista, A., Cheley, S., MacDonald, P. E., & Braun, M. (2014) · Diabetologia

Adenosine and Purinergic SignalingPancreatic function and diabetes

Cited by 52

Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels in Pancreatic β-Cells

El-Kholy, W., MacDonald, P. E., Fox, J. M., Bhattacharjee, A., Xue, T., Gao, X., Zhang, Y., Stieber, J., Li, R. A., Tsushima, R. G., et al. (2007) · Molecular Endocrinology

Pancreatic function and diabetesIon channel regulation and function

Cited by 33

Cryopreservation and post-thaw characterization of dissociated human islet cells

Marquez-Curtis, L. A., Dai, X.-Q., Hang, Y., Lam, J. Y., Lyon, J., Manning Fox, J. E., McGann, L. E., MacDonald, P. E., Kim, S. K., & Elliott, J. A. W. (2022) · PLOS ONE

Pancreatic function and diabetesDiabetes and associated disorders

Cited by 26

Scalable bioreactor-based suspension approach to generate stem cell-derived islets from healthy donor-derived iPSCs

Verhoeff, K., Cuesta-Gomez, N., Maghera, J., Dadheech, N., Pawlick, R., Smith, N., O’Gorman, D., Razavy, H., Marfil-Garza, B., Young, L. G., et al. (2025) · Transplantation

Pancreatic function and diabetesPluripotent Stem Cells Research

Cited by 16