Hoek, Jan B.

Alcohol and mitochondria: a dysfunctional relationship

Hoek, J. B., Cahill, A., & Pastorino, J. G. (2002) · Gastroenterology

Mitochondrial Function and PathologyAlcohol Consumption and Health Effects

Cited by 553

The path from mitochondrial ROS to aging runs through the mitochondrial permeability transition pore

Rottenberg, H., & Hoek, J. B. (2017) · Aging Cell

Mitochondrial Function and PathologyGenetics, Aging, and Longevity in Model Organisms

Cited by 275

Systems-level interactions between insulin–EGF networks amplify mitogenic signaling

Borisov, N., Aksamitiene, E., Kiyatkin, A., Legewie, S., Berkhout, J., Maiwald, T., Kaimachnikov, N. P., Timmer, J., Hoek, J. B., & Kholodenko, B. N. (2009) · Molecular Systems Biology

Protein Kinase Regulation and GTPase SignalingGene Regulatory Network Analysis

Cited by 222

MICU1 regulation of mitochondrial Ca2+ uptake dictates survival and tissue regeneration

Antony, A. N., Paillard, M., Moffat, C., Juskeviciute, E., Correnti, J., Bolon, B., Rubin, E., Csordás, G., Seifert, E. L., Hoek, J. B., et al. (2016) · Nature Communications

Mitochondrial Function and PathologyLiver physiology and pathology

Cited by 206

Scaffolding Protein Grb2-associated Binder 1 Sustains Epidermal Growth Factor-induced Mitogenic and Survival Signaling by Multiple Positive Feedback Loops

Kiyatkin, A., Aksamitiene, E., Markevich, N. I., Borisov, N. M., Hoek, J. B., & Kholodenko, B. N. (2006) · Journal of Biological Chemistry

Protein Kinase Regulation and GTPase SignalingPI3K/AKT/mTOR signaling in cancer

Cited by 195

Mitochondrial Uncoupling: Role of Uncoupling Protein Anion Carriers and Relationship to Thermogenesis and Weight Control “The Benefits of Losing Control”

Diehl, A. M., & Hoek, J. B. (1999) · Journal of Bioenergetics and Biomembranes

Mitochondrial Function and PathologyAdipose Tissue and Metabolism

Cited by 95

The mitochondrial permeability transition: Nexus of aging, disease and longevity

Rottenberg, H., & Hoek, J. B. (2021) · Cells

Mitochondrial Function and PathologyAutophagy in Disease and Therapy

Cited by 94

Why do protein kinase cascades have more than one level?

Brown, G. C., Hoek, J. B., & Kholodenko, B. N. (1997) · Trends in Biochemical Sciences

Protein Kinase Regulation and GTPase SignalingGene Regulatory Network Analysis

Cited by 88