Mitochondrial Uncoupling: Role of Uncoupling Protein Anion Carriers and Relationship to Thermogenesis and Weight Control “The Benefits of Losing Control”

Diehl, Anna Mae; Hoek, Jan B.

doi:10.1023/a:1005452624640

Cited by 95Mitochondrial Function and PathologyAdipose Tissue and MetabolismMetabolism, Diabetes, and Cancer

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Mitochondrial Uncoupling: Role of Uncoupling Protein Anion Carriers and Relationship to Thermogenesis and Weight Control “The Benefits of Losing Control”

Diehl, Anna Mae, Hoek, Jan B.·1999·Journal of Bioenergetics and Biomembranes

DOI 10.1023/a:1005452624640

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Abstract

Uncoupling proteins, a subgroup of the mitochondrial anion transporter superfamily, have been identified in prokaryotes, plants, and mammalian cells. Evolutionary conservation of these molecules reflects their importance as regulators of two critical mitochondrial functions, i.e., ATP synthesis and the production of reactive oxygen species (ROS). Although the amino acid sequences of the three mammalian uncoupling proteins, UCP1, UCP2 and UCP3, are very similar, each homolog is the product of a unique gene and important differences have been demonstrated in their tissue-specific expression and regulation. UCP1 and UCP3 appear to be key regulators of energy expenditure, and hence, nonshivering thermogenesis, either in brown adipose tissue (UCP1) or skeletal muscle (UCP3). UCP2 is expressed more ubiquitously, although generally at low levels, in many tissues. There is conflicting evidence about its importance as a regulator of resting metabolic rate. However, evidence suggests that this homolog might modulate the mitochondrial generation of ROS in some cell types, including macrophages and hepatocytes. While the induction of various uncoupling protein homologs provides adaptive advantages, both to the organism (e.g., thermogenesis) and to individual cells (e.g., reduced ROS), increased uncoupling protein activity also increases cellular vulnerability to necrosis by compromising the mitochondrial membrane potential. This narrow "risk-benefit" margin necessitates tight control of uncoupling protein activity in order to preserve cellular viability and much remains to be learned about the regulatory mechanisms involved.

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Uncontrolled mitochondrial uncoupling could cause a life-threatening rise in body temperature and ATP depletion.
“uncontrolled mitochondrial uncoupling could lead to a life-threatening increase in body temperature and ATP depletion (151).”
From Altered mitochondrial function in insulin-deficient and insulin-resistant states (2018) · cites this paper as [151]

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Untitled work
Collins (1998) · doi:10.1002/(sici)1097-4652(199807)176:1

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Authors: Diehl, A. M., & Hoek, J. B.
Affiliations: Johns Hopkins University (US)
Thomas Jefferson University (US)
Corresponding author: Diehl, Anna Mae
ORCID: Diehl, Anna Mae
Hoek, Jan B.
Venue: Journal of Bioenergetics and Biomembranes
Publisher: Springer Science and Business Media LLC
Published: 1999-10
Volume: 31
Issue: 5
Pages: 493-506
ISSN: 0145-479X (ISSN-L)
1573-6881
DOI: 10.1023/a:1005452624640
OpenAlex: W56406267
Cited by: 95
References: 122
Citations by year: 2025: 1 · 2024: 2 · 2022: 1 · 2021: 1 · 2018: 7 · 2017: 4 · 2016: 1 · 2015: 3 · 2014: 5 · 2013: 2 · 2012: 4
FWCI: 0.66
Type: journal article
Language: en
Open access: closed
Licence: www.springernature.com/gp/researchers/text-and-data-mining (tdm)
www.springernature.com/gp/researchers/text-and-data-mining (vor)
Locations: Journal of Bioenergetics and Biomembranes (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Keywords: uncoupling proteins, mitochondrial uncoupling, UCP1, UCP2, UCP3, thermogenesis, brown adipose tissue, skeletal muscle, energy expenditure, weight management, reactive oxygen species, mitochondrial membrane potential, necrosis, resting metabolic rate, tissue-specific gene expression
MeSH terms: Uncoupling Protein 2, Uncoupling Protein 1, Animals, Anions, Body Weight, Carrier Proteins, Ion Channels, Membrane Proteins, Mitochondria, Proteins, Uncoupling Agents, Apoptosis, Reactive Oxygen Species, Mitochondrial Proteins, Membrane Transport Proteins

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Mitochondrial Uncoupling: Role of Uncoupling Protein Anion Carriers and Relationship to Thermogenesis and Weight Control “The Benefits of Losing Control”

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