Chen, Janice S.

CRISPR-Cas12a target binding unleashes indiscriminate single-stranded DNase activity

Chen, J. S., Ma, E., Harrington, L. B., Da Costa, M., Tian, X., Palefsky, J. M., & Doudna, J. A. (2018) · Science

CRISPR and Genetic EngineeringAdvanced biosensing and bioanalysis techniques

Cited by 4,507

Enhanced proofreading governs CRISPR-Cas9 targeting accuracy

Chen, J. S., Dagdas, Y. S., Kleinstiver, B. P., Welch, M. M., Sousa, A. A., Harrington, L. B., Sternberg, S. H., Joung, J. K., Yildiz, A., & Doudna, J. A. (2017) · Nature

CRISPR and Genetic EngineeringRNA regulation and disease

Cited by 1,168

A conformational checkpoint between DNA binding and cleavage by CRISPR-Cas9

Dagdas, Y. S., Chen, J. S., Sternberg, S. H., Doudna, J. A., & Yildiz, A. (2017) · Science Advances

CRISPR and Genetic EngineeringDNA and Nucleic Acid Chemistry

Cited by 293

A Thermostable Cas9 with Increased Lifetime in Human Plasma

Harrington, L. B., Paez-Espino, D., Staahl, B. T., Chen, J. S., Ma, E., Kyrpides, N. C., & Doudna, J. A. (2017) · Nature Communications

CRISPR and Genetic EngineeringRNA regulation and disease

Cited by 205

Key role of the REC lobe during CRISPR–Cas9 activation by ‘sensing’, ‘regulating’, and ‘locking’ the catalytic HNH domain

Palermo, G., Chen, J. S., Ricci, C. G., Rivalta, I., Jinek, M., Batista, V. S., Doudna, J. A., & McCammon, J. A. (2018) · Quarterly Reviews of Biophysics

CRISPR and Genetic EngineeringProtein Structure and Dynamics

Cited by 123