Downing, Timothy L.

YAP-mediated mechanotransduction tunes the macrophage inflammatory response

Meli, V. S., Atcha, H., Veerasubramanian, P. K., Nagalla, R. R., Luu, T. U., Chen, E. Y., Guerrero-Juarez, C. F., Yamaga, K., Pandori, W., Hsieh, J. Y., et al. (2020) · Science Advances

Cellular Mechanics and InteractionsHippo pathway signaling and YAP/TAZ

Cited by 329

Biophysical regulation of macrophages in health and disease

Meli, V. S., Veerasubramanian, P. K., Atcha, H., Reitz, Z., Downing, T. L., & Liu, W. F. (2019) · Journal of Leukocyte Biology

Cellular Mechanics and InteractionsCell Adhesion Molecules Research

Cited by 133

A Src-H3 acetylation signaling axis integrates macrophage mechanosensation with inflammatory response

Veerasubramanian, P. K., Shao, H., Meli, V. S., Phan, T. A. Q., Luu, T. U., Liu, W. F., & Downing, T. L. (2021) · Biomaterials

Cellular Mechanics and InteractionsGenomics and Chromatin Dynamics

Cited by 28

Scalable Inference and Identifiability of Kinetic Parameters for Transcriptional Bursting from Single Cell Data

Gu, J., Laszik, N., Miles, C. E., Allard, J., Downing, T. L., & Read, E. L. (2025) · Bioinformatics

Gene Regulatory Network AnalysisSingle-cell and spatial transcriptomics

Cited by 6