Biophysical regulation of macrophages in health and disease

Calcium's Role in Mechanotransduction during Muscle Development

Damm, T. B., & Egli, M. (2014) · Cellular Physiology and Biochemistry · doi:10.1159/000356667 · Cited by 14,548 · see citing works

Matrix elasticity directs stem cell lineage specification

Engler, A. J., Sen, S., Sweeney, H. L., & Discher, D. E. (2006) · Cell · doi:10.1016/j.cell.2006.06.044 · Cited by 13,915 · see citing works

Exploring the full spectrum of macrophage activation

Mosser, D. M., & Edwards, J. P. (2008) · Nature Reviews Immunology · doi:10.1038/nri2448 · Cited by 9,144 · see citing works

Untitled work

Hynes (2002) · doi:10.1016/s0092-8674(02)00971-6 · Cited by 8,606 · see citing works

Tissue Cells Feel and Respond to the Stiffness of Their Substrate

Discher, D. E., Janmey, P., & Wang, Y.-L. (2005) · Science · doi:10.1126/science.1116995 · Cited by 6,382 · see citing works

Role of YAP/TAZ in mechanotransduction

Dupont, S., Morsut, L., Aragona, M., Enzo, E., Giulitti, S., Cordenonsi, M., Zanconato, F., Le Digabel, J., Forcato, M., Bicciato, S., et al. (2011) · Nature · doi:10.1038/nature10137 · Cited by 5,979 · see citing works

Modulating Innate and Adaptive Immunity by (R)-Roscovitine: Potential Therapeutic Opportunity in Cystic Fibrosis

Meijer, L., Nelson, D. J., Riazanski, V., Gabdoulkhakova, A. G., Héry-Arnaud, G., Berre, R. L., Loaëc, N., Oumata, N., Galons, H., Nowak, E., et al. (2016) · Journal of Innate Immunity · doi:10.1159/000444256 · Cited by 4,992 · see citing works

Macrophage biology in development, homeostasis and disease

Wynn, T. A., Chawla, A., & Pollard, J. W. (2013) · Nature · doi:10.1038/nature12034 · Cited by 4,684 · see citing works

Macrophages in Tissue Repair, Regeneration, and Fibrosis

Wynn, T. A., & Vannella, K. M. (2016) · Immunity · doi:10.1016/j.immuni.2016.02.015 · Cited by 4,481 · see citing works

Tumour-associated macrophages as treatment targets in oncology

Mantovani, A., Marchesi, F., Malesci, A., Laghi, L., & Allavena, P. (2017) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2016.217 · Cited by 4,065 · see citing works

Mechanisms of fibrosis: therapeutic translation for fibrotic disease

Wynn, T. A., & Ramalingam, T. R. (2012) · Nature Medicine · doi:10.1038/nm.2807 · Cited by 3,541 · see citing works

Mechanotransduction Across the Cell Surface and Through the Cytoskeleton

Wang, N., Butler, J. P., & Ingber, D. E. (1993) · Science · doi:10.1126/science.7684161 · Cited by 3,007 · see citing works

Macrophage Polarization

Murray, P. J. (2017) · Annual Review of Physiology · doi:10.1146/annurev-physiol-022516-034339 · Cited by 2,981 · see citing works

Environmental sensing through focal adhesions

Geiger, B., Spatz, J. P., & Bershadsky, A. D. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2593 · Cited by 2,543 · see citing works

Extracellular Matrix Degradation and Remodeling in Development and Disease

Lu, P., Takai, K., Weaver, V. M., & Werb, Z. (2011) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a005058 · Cited by 2,265 · see citing works

Transcriptome-Based Network Analysis Reveals a Spectrum Model of Human Macrophage Activation

Xue, J., Schmidt, S. V., Sander, J., Draffehn, A., Krebs, W., Quester, I., De Nardo, D., Gohel, T. D., Emde, M., Schmidleithner, L., et al. (2014) · Immunity · doi:10.1016/j.immuni.2014.01.006 · Cited by 2,210 · see citing works

Tissue-Resident Macrophage Enhancer Landscapes Are Shaped by the Local Microenvironment

Lavin, Y., Winter, D., Blecher-Gonen, R., David, E., Keren-Shaul, H., Merad, M., Jung, S., & Amit, I. (2014) · Cell · doi:10.1016/j.cell.2014.11.018 · Cited by 2,167 · see citing works

The extracellular matrix modulates the hallmarks of cancer

Pickup, M. W., Mouw, J. K., & Weaver, V. M. (2014) · EMBO Reports · doi:10.15252/embr.201439246 · Cited by 2,014 · see citing works

Nuclear Lamin-A Scales with Tissue Stiffness and Enhances Matrix-Directed Differentiation

Swift, J., Ivanovska, I. L., Buxboim, A., Harada, T., Dingal, P. C. D. P., Pinter, J., Pajerowski, J. D., Spinler, K. R., Shin, J., Tewari, M., et al. (2013) · Science · doi:10.1126/science.1240104 · Cited by 1,998 · see citing works

Demonstration of mechanical connections between integrins, cytoskeletal filaments, and nucleoplasm that stabilize nuclear structure

Maniotis, A. J., Chen, C. S., & Ingber, D. E. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.3.849 · Cited by 1,606 · see citing works

Suppression of inflammation by a synthetic histone mimic

Nicodeme, E., Jeffrey, K. L., Schaefer, U., Beinke, S., Dewell, S., Chung, C.-W., Chandwani, R., Marazzi, I., Wilson, P., Coste, H., et al. (2010) · Nature · doi:10.1038/nature09589 · Cited by 1,563 · see citing works

Force triggers YAP nuclear entry by regulating transport across nuclear pores

Elosegui-Artola, A., Andreu, I., Beedle, A. E. M., Lezamiz, A., Uroz, M., Kosmalska, A. J., Oria, R., Kechagia, J. Z., Rico-Lastres, P., Le Roux, A.-L., et al. (2017) · Cell · doi:10.1016/j.cell.2017.10.008 · Cited by 1,491 · see citing works

Modulation of macrophage phenotype by cell shape

McWhorter, F. Y., Wang, T., Nguyen, P., Chung, T., & Liu, W. F. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1308887110 · Cited by 1,482 · see citing works

Mechanobiology of YAP and TAZ in physiology and disease

Panciera, T., Azzolin, L., Cordenonsi, M., & Piccolo, S. (2017) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.87 · Cited by 1,461 · see citing works

Mechanotransduction gone awry

Jaalouk, D. E., & Lammerding, J. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2597 · Cited by 1,396 · see citing works

Coupling of the nucleus and cytoplasm: Role of the LINC complex

Crisp, M., Liu, Q., Roux, K. J., Rattner, J. B., Shanahan, C. M., Burke, B. E., Stahl, P. D., & Hodzic, D. M. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200509124 · Cited by 1,339 · see citing works

MACROPHAGE RECEPTORS AND IMMUNE RECOGNITION

Taylor, P. R., Martínez‐Pomares, L., Stacey, M. A., Lin, H.-H., Brown, G. D., & Gordon, S. (2005) · Annual Review of Immunology · doi:10.1146/annurev.immunol.23.021704.115816 · Cited by 1,325 · see citing works

Hemodynamic shear stress and the endothelium in cardiovascular pathophysiology

Davies, P. F. (2008) · Nature Clinical Practice Cardiovascular Medicine · doi:10.1038/ncpcardio1397 · Cited by 1,216 · see citing works

Functional atlas of the integrin adhesome

Zaidel‐Bar, R., Itzkovitz, S., Ma’ayan, A., Iyengar, R., & Geiger, B. (2007) · Nature Cell Biology · doi:10.1038/ncb0807-858 · Cited by 1,182 · see citing works

The trp ion channel family

Clapham, D. E., Runnels, L. W., & Strübing, C. (2001) · Nature reviews. Neuroscience · doi:10.1038/35077544 · Cited by 1,155 · see citing works

Macrophage Phenotype and Function in Different Stages of Atherosclerosis

Tabas, I., & Bornfeldt, K. E. (2016) · Circulation Research · doi:10.1161/circresaha.115.306256 · Cited by 1,121 · see citing works

YAP/TAZ upstream signals and downstream responses

Totaro, A., Panciera, T., & Piccolo, S. (2018) · Nature Cell Biology · doi:10.1038/s41556-018-0142-z · Cited by 1,086 · see citing works

Integrin-mediated mechanotransduction

Sun, Z., Guo, S., & Fässler, R. (2016) · The Journal of Cell Biology · doi:10.1083/jcb.201609037 · Cited by 1,079 · see citing works

Preparation of Hydrogel Substrates with Tunable Mechanical Properties

Tse, J. R., & Engler, A. J. (2010) · Current Protocols in Cell Biology · doi:10.1002/0471143030.cb1016s47 · Cited by 1,070 · see citing works

Lamin A/C deficiency causes defective nuclear mechanics and mechanotransduction

Lammerding, J., Schulze, P. C., Takahashi, T., Kozlov, S. V., Sullivan, T. L., Kamm, R. D., Stewart, C. L., & Lee, R. T. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200419670 · Cited by 1,068 · see citing works

The role of matrix stiffness in regulating cell behavior†

Wells, R. G. (2008) · Hepatology · doi:10.1002/hep.22193 · Cited by 1,055 · see citing works

Transduction of mechanical and cytoskeletal cues by YAP and TAZ

Halder, G., Dupont, S., & Piccolo, S. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3416 · Cited by 985 · see citing works

Mechanotransduction and the functional response of bone to mechanical strain

Duncan, R., & Turner, C. (1995) · Calcified Tissue International · doi:10.1007/bf00302070 · Cited by 944 · see citing works

Engineering Hydrogels as Extracellular Matrix Mimics

Geçkil, H., Xu, F., Zhang, X., Moon, S., & Demirci, U. (2010) · Nanomedicine · doi:10.2217/nnm.10.12 · Cited by 943 · see citing works

Mechanobiology and diseases of mechanotransduction

Ingber, D. E. (2003) · Annals of Medicine · doi:10.1080/07853890310016333 · Cited by 842 · see citing works

Mechanisms of Mechanotransduction

Orr, A. W., Helmke, B. P., Blackman, B. R., & Schwartz, M. A. (2006) · Developmental Cell · doi:10.1016/j.devcel.2005.12.006 · Cited by 809 · see citing works

Sequential delivery of immunomodulatory cytokines to facilitate the M1-to-M2 transition of macrophages and enhance vascularization of bone scaffolds

Spiller, K. L., Nassiri, S., Witherel, C. E., Anfang, R. R., Ng, J., Nakazawa, K. R., Yu, T., & Vunjak-Novakovic, G. (2015) · Biomaterials · doi:10.1016/j.biomaterials.2014.10.017 · Cited by 773 · see citing works

Ion Channels in Innate and Adaptive Immunity

Feske, S., Wulff, H., & Skolnik, E. Y. (2015) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032414-112212 · Cited by 764 · see citing works

Integrins in Mechanotransduction

Katsumi, A., Orr, A. W., Tzima, E., & Schwartz, M. A. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.r300038200 · Cited by 724 · see citing works

Macrophage heterogeneity in tissues: phenotypic diversity and functions

Gordon, S., Plüddemann, A., & Martínez, F. O. (2014) · Immunological Reviews · doi:10.1111/imr.12223 · Cited by 713 · see citing works

Identification and characterization of enhancers controlling the inflammatory gene expression program in macrophages

Ghisletti, S., Barozzi, I., Mietton, F., Polletti, S., De Santa, F., Venturini, E., Gregory, L., Lonie, L., Chew, A., Wei, C.-L., et al. (2010) · Immunity · doi:10.1016/j.immuni.2010.02.008 · Cited by 666 · see citing works

“Laminopathies”: A wide spectrum of human diseases

Worman, H. J., & Bonne, G. (2007) · Experimental Cell Research · doi:10.1016/j.yexcr.2007.03.028 · Cited by 657 · see citing works

Characterization of the Drosophila melanogaster genome at the nuclear lamina

Pickersgill, H., Kalverda, B., de Wit, E., Talhout, W., Fornerod, M., & van Steensel, B. (2006) · Nature Genetics · doi:10.1038/ng1852 · Cited by 656 · see citing works

Tissue Stiffness Dictates Development, Homeostasis, and Disease Progression

Handorf, A. M., Zhou, Y., Halanski, M. A., & Li, W. (2015) · Organogenesis · doi:10.1080/15476278.2015.1019687 · Cited by 647 · see citing works

Transcription upregulation via force-induced direct stretching of chromatin

Tajik, A., Zhang, Y., Wei, F., Sun, J., Jia, Q., Zhou, W., Singh, R., Khanna, N., Belmont, A. S., & Wang, N. (2016) · Nature Materials · doi:10.1038/nmat4729 · Cited by 633 · see citing works

Transcriptional regulation via the NF-κB signaling module

Hoffmann, A., Natoli, G., & Ghosh, G. (2006) · Oncogene · doi:10.1038/sj.onc.1209933 · Cited by 629 · see citing works

Isolated nuclei adapt to force and reveal a mechanotransduction pathway in the nucleus

Guilluy, C., Osborne, L. D., Landeghem, L. V., Sharek, L., Superfine, R., García‐Mata, R., & Burridge, K. (2014) · Nature Cell Biology · doi:10.1038/ncb2927 · Cited by 613 · see citing works

Actin' together: serum response factor, its cofactors and the link to signal transduction.

Posern, G., & Treisman, R. (2006) · Trends in Cell Biology · doi:10.1016/j.tcb.2006.09.008 · Cited by 560 · see citing works

A common mechanism underlies stretch activation and receptor activation of TRPC6 channels

Spassova, M. A., Hewavitharana, T., Xu, W., Soboloff, J., & Gill, D. L. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0606894103 · Cited by 517 · see citing works

Rho GTPases: molecular switches that control the organization and dynamics of the actin cytoskeleton

Hall, A. K., & Nobes, C. D. (2000) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2000.0632 · Cited by 513 · see citing works

Mechanical Strain and Bone Cell Function: A Review

Ehrlich, P. J., & Lanyon, L. E. (2002) · Osteoporosis International · doi:10.1007/s001980200095 · Cited by 509 · see citing works

Phenotype of Mice and Macrophages Deficient in Both Phagocyte Oxidase and Inducible Nitric Oxide Synthase

Shiloh, M. U., MacMicking, J. D., Nicholson, S., Brause, J. E., Potter, S. H., Marino, M., Fang, F. C., Dinauer, M. C., & Nathan, C. (1999) · Immunity · doi:10.1016/s1074-7613(00)80004-7 · Cited by 504 · see citing works

Calcium signaling in immune cells

Vig, M., & Kinet, J. (2008) · Nature Immunology · doi:10.1038/ni.f.220 · Cited by 494 · see citing works

Biophysical regulation of epigenetic state and cell reprogramming

Downing, T. L., Soto, J., Morez, C., Houssin, T., Fritz, A. L., Yuan, F., Chu, J. S. F., Patel, S. A., Schaffer, D. V., & Li, S. (2013) · Nature Materials · doi:10.1038/nmat3777 · Cited by 493 · see citing works

Arterial stiffness, atherosclerosis and cardiovascular risk: Pathophysiologic mechanisms and emerging clinical indications

Palombo, C., & Kozàkovà, M. (2015) · Vascular Pharmacology · doi:10.1016/j.vph.2015.11.083 · Cited by 477 · see citing works

Flow-dependent YAP/TAZ activities regulate endothelial phenotypes and atherosclerosis

Wang, K.-C., Yeh, Y.-T., Nguyen, P., Limqueco, E., Lopez, J., Thorossian, S., Guan, K.-L., Li, Y.-S. J., & Chien, S. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1613121113 · Cited by 471 · see citing works

Student award winner in the undergraduate category for the society of biomaterials 9th World Biomaterials Congress, Chengdu, China, June 1–5, 2012: The effects of substrate stiffness on the <i>in vitro</i> activation of macrophages and <i>in vivo</i> host response to poly(ethylene glycol)‐based hydrogels

Blakney, A. K., Swartzlander, M. D., & Bryant, S. J. (2012) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.34104 · Cited by 470 · see citing works

Mechanisms of mechanical signaling in development and disease

Janmey, P. A., & Miller, R. T. (2010) · Journal of Cell Science · doi:10.1242/jcs.071001 · Cited by 462 · see citing works

Integrin CD11b negatively regulates TLR-triggered inflammatory responses by activating Syk and promoting degradation of MyD88 and TRIF via Cbl-b

Han, C., Jin, J., Xu, S., Liu, H., Li, N., & Cao, X. (2010) · Nature Immunology · doi:10.1038/ni.1908 · Cited by 458 · see citing works

Macrophage functional polarization (M1/M2) in response to varying fiber and pore dimensions of electrospun scaffolds

Garg, K., Pullen, N. A., Oskeritzian, C. A., Ryan, J. J., & Bowlin, G. L. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.02.065 · Cited by 457 · see citing works

Lamin A/C and emerin regulate MKL1–SRF activity by modulating actin dynamics

Ho, C. Y., Jaalouk, D. E., Vartiainen, M. K., & Lammerding, J. (2013) · Nature · doi:10.1038/nature12105 · Cited by 456 · see citing works

Rapid signal transduction in living cells is a unique feature of mechanotransduction

Na, S., Collin, O., Chowdhury, F., Tay, B., Ouyang, M., Wang, Y., & Wang, N. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0711704105 · Cited by 449 · see citing works

The nuclear envelope and transcriptional control

Akhtar, A., & Gasser, S. M. (2007) · Nature Reviews Genetics · doi:10.1038/nrg2122 · Cited by 443 · see citing works

Physical and mechanical regulation of macrophage phenotype and function

McWhorter, F. Y., Davis, C. T., & Liu, W. F. (2015) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-014-1796-8 · Cited by 437 · see citing works

The effect of thick fibers and large pores of electrospun poly(ε-caprolactone) vascular grafts on macrophage polarization and arterial regeneration

Wang, Z., Cui, Y., Wang, J., Yang, X., Wu, Y., Wang, K., Gao, X., Li, D., Li, Y., Zheng, X., et al. (2014) · Biomaterials · doi:10.1016/j.biomaterials.2014.03.078 · Cited by 436 · see citing works

Porous Implants Modulate Healing and Induce Shifts in Local Macrophage Polarization in the Foreign Body Reaction

Sussman, E. M., Halpin, M. C., Muster, J., Moon, R. T., & Ratner, B. D. (2014) · Annals of Biomedical Engineering · doi:10.1007/s10439-013-0933-0 · Cited by 416 · see citing works

Functional roles of p38 mitogen-activated protein kinase in macrophage-mediated inflammatory responses

Yang, Y., Kim, S. C., Yu, T., Yi, Y.-S., Rhee, M. H., Sung, G.-H., Yoo, B. C., & Cho, J. Y. (2014) · Mediators of Inflammation · doi:10.1155/2014/352371 · Cited by 406 · see citing works

Assembly and biological role of podosomes and invadopodia

Gimona, M., Buccione, R., Courtneidge, S. A., & Linder, S. (2008) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2008.01.005 · Cited by 404 · see citing works

Age-Related Intimal Stiffening Enhances Endothelial Permeability and Leukocyte Transmigration

Huynh, J., Nishimura, N., Rana, K., Peloquin, J. M., Califano, J. P., Montague, C. R., King, M. R., Schaffer, C. B., & Reinhart‐King, C. A. (2011) · Science Translational Medicine · doi:10.1126/scitranslmed.3002761 · Cited by 403 · see citing works

Mechanosensitive mechanisms in transcriptional regulation

Mammoto, A., Mammoto, T., & Ingber, D. E. (2012) · Journal of Cell Science · doi:10.1242/jcs.093005 · Cited by 393 · see citing works

Fc-receptor-mediated phagocytosis is regulated by mechanical properties of the target

Beningo, K. A., & Wang, Y.-L. (2002) · Journal of Cell Science · doi:10.1242/jcs.115.4.849 · Cited by 389 · see citing works

Expression of ICAM-1 and VCAM-1 and Monocyte Adherence in Arteries Exposed to Altered Shear Stress

Walpola, P. L., Gotlieb, A. I., Cybulsky, M. I., & Langille, B. L. (1995) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.15.1.2 · Cited by 389 · see citing works

Proliferation and recruitment contribute to myocardial macrophage expansion in chronic heart failure

Sager, H., Hulsmans, M., Lavine, K. J., Moreira, M. B., Heidt, T., Courties, G., Sun, Y., Iwamoto, Y., Tricot, B., Khan, O. F., et al. (2016) · Circulation Research · doi:10.1161/circresaha.116.309001 · Cited by 377 · see citing works

MAP kinase activation in macrophages

Rao, K. M. K. (2001) · Journal of Leukocyte Biology · doi:10.1189/jlb.69.1.3 · Cited by 371 · see citing works

Cdc42, Rac1, and Rac2 Display Distinct Patterns of Activation during Phagocytosis

Hoppe, A. D., & Swanson, J. A. (2004) · Molecular Biology of the Cell · doi:10.1091/mbc.e03-11-0847 · Cited by 365 · see citing works

Cell geometric constraints induce modular gene-expression patterns via redistribution of HDAC3 regulated by actomyosin contractility

Jain, N., Iyer, K. V., Kumar, A., & Shivashankar, G. V. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1300801110 · Cited by 362 · see citing works

Epigenetics and Human DiseasePreprint

Zoghbi, H. Y., & Beaudet, A. L. (2016) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a019497 · Cited by 361 · see citing works

Guidance and Activation of Murine Macrophages by Nanometric Scale Topography

Wójciak‐Stothard, B., Curtis, A. S. G., Monaghan, W., Macdonald, K., & Wilkinson, C. D. W. (1996) · Experimental Cell Research · doi:10.1006/excr.1996.0098 · Cited by 354 · see citing works

Activation of human macrophages by mechanical ventilation in vitro

Pugin, J., Dunn-Siegrist, I., Jolliet, P., Tassaux, D., Magnenat, J.-L., Nicod, L. P., & Chevrolet, J.-C. (1998) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.1998.275.6.l1040 · Cited by 352 · see citing works

Micro- and Nanopatterned Topographical Cues for Regulating Macrophage Cell Shape and Phenotype

Luu, T. U., Gott, S. C., Woo, B. W. K., Rao, M. P., & Liu, W. F. (2015) · ACS Applied Materials &amp; Interfaces · doi:10.1021/acsami.5b10589 · Cited by 344 · see citing works

The Mechanism of Action of the Vacuum-Assisted Closure Device

Scherer, S. S., Pietramaggiori, G., Mathews, J. C., Prsa, M. J., Huang, S., & Orgill, D. P. (2008) · Plastic & Reconstructive Surgery · doi:10.1097/prs.0b013e31818237ac · Cited by 332 · see citing works

TRPV2 has a pivotal role in macrophage particle binding and phagocytosis

Link, T. M., Park, U., Vonakis, B. M., Raben, D. M., Soloski, M. J., & Caterina, M. J. (2010) · Nature Immunology · doi:10.1038/ni.1842 · Cited by 323 · see citing works

Improved implant osseointegration of a nanostructured titanium surface via mediation of macrophage polarization

Ma, Q.-L., Zhao, L.-Z., Liu, R.-R., Jin, B.-Q., Song, W., Wang, Y., Zhang, Y.-S., Chen, L.-H., & Zhang, Y.-M. (2014) · Biomaterials · doi:10.1016/j.biomaterials.2014.08.025 · Cited by 319 · see citing works

Dynamic phototuning of 3D hydrogel stiffness

Stowers, R. S., Allen, S. C., & Suggs, L. J. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1421897112 · Cited by 309 · see citing works

Effect of titanium surface topography on macrophage activation and secretion of proinflammatory cytokines and chemokines

Refai, A. K., Textor, M., Brunette, D. M., & Waterfield, J. D. (2004) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.30075 · Cited by 296 · see citing works

Electrical and mechanical stimulation of cardiac cells and tissue constructs

Stoppel, W. L., Kaplan, D. L., & Black, L. D. (2015) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2015.07.009 · Cited by 290 · see citing works

Effect of Electrospun Fiber Diameter and Alignment on Macrophage Activation and Secretion of Proinflammatory Cytokines and Chemokines

Saino, E., Focarete, M. L., Gualandi, C., Emanuele, E., Cornaglia, A. I., Imbriani, M., & Visai, L. (2011) · Biomacromolecules · doi:10.1021/bm200248h · Cited by 285 · see citing works

Cell Elasticity Determines Macrophage Function

Patel, N. R., Bole, M., Chen, C., Hardin, C. C., Kho, A. T., Mih, J., Deng, L., Butler, J., Tschumperlin, D., Fredberg, J. J., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0041024 · Cited by 275 · see citing works

Spatial confinement downsizes the inflammatory response of macrophages

Jain, N., & Vogel, V. (2018) · Nature Materials · doi:10.1038/s41563-018-0190-6 · Cited by 271 · see citing works

Biophysical Regulation of Cell Behavior—Cross Talk between Substrate Stiffness and Nanotopography

Yang, Y. S., Wang, K., Gu, X., & Leong, K. W. (2017) · Engineering · doi:10.1016/j.eng.2017.01.014 · Cited by 264 · see citing works

Flexible substrata for the detection of cellular traction forces

Beningo, K. A., & Wang, Y.-L. (2002) · Trends in Cell Biology · doi:10.1016/s0962-8924(01)02205-x · Cited by 258 · see citing works

Hv1 proton channels are required for high-level NADPH oxidase-dependent superoxide production during the phagocyte respiratory burst

Ramsey, I. S., Ruchti, E., Kaczmarek, J. S., & Clapham, D. E. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0902761106 · Cited by 255 · see citing works

Integrin alpha v beta 3 differentially regulates adhesive and phagocytic functions of the fibronectin receptor alpha 5 beta 1.

Blystone, S. D., Graham, I. L., Lindberg, F. P., & Brown, E. J. (1994) · The Journal of Cell Biology · doi:10.1083/jcb.127.4.1129 · Cited by 254 · see citing works

Integrin‐Mediated Interactions Control Macrophage Polarization in 3D Hydrogels

Cha, B., Shin, S. R., Leijten, J., Li, Y., Singh, S., Liu, J. C., Annabi, N., Abdi, R., Dokmeci, M. R., Vrana, N. E., et al. (2017) · Advanced Healthcare Materials · doi:10.1002/adhm.201700289 · Cited by 251 · see citing works

Chanzyme TRPM7 Mediates the Ca2+ Influx Essential for Lipopolysaccharide-Induced Toll-Like Receptor 4 Endocytosis and Macrophage Activation

Schappe, M. S., Szteyn, K., Stremska, M. E., Mendu, S. K., Downs, T. K., Seegren, P. V., Mahoney, M. A., Dixit, S., Krupa, J. K., Stipes, E. J., et al. (2018) · Immunity · doi:10.1016/j.immuni.2017.11.026 · Cited by 251 · see citing works

Heterogeneity of Human Macrophages in Culture and in Atherosclerotic Plaques

Waldo, S. W., Li, Y., Buono, C., Zhao, B. N., Billings, E. M., Chang, J., & Kruth, H. S. (2008) · American Journal Of Pathology · doi:10.2353/ajpath.2008.070513 · Cited by 250 · see citing works

Mechanical stretch: physiological and pathological implications for human vascular endothelial cells

Jufri, N. F., Mohamedali, A., Avolio, A. P., & Baker, M. S. (2015) · Vascular Cell · doi:10.1186/s13221-015-0033-z · Cited by 246 · see citing works

Fabrication of Hydrogels with Steep Stiffness Gradients for Studying Cell Mechanical Response

Sunyer, R., Jin, A. J., Nossal, R., & Sackett, D. L. (2012) · PLoS ONE · doi:10.1371/journal.pone.0046107 · Cited by 238 · see citing works

Epigenetic Regulation of Macrophage Polarization by DNA Methyltransferase 3b

Yang, X., Wang, X., Liu, D., Yu, L., Xue, B., & Shi, H. (2014) · Molecular Endocrinology · doi:10.1210/me.2013-1293 · Cited by 235 · see citing works

Simple Approach to Micropattern Cells on Common Culture Substrates by Tuning Substrate Wettability

Tan, J. L., Liu, W. F., Nelson, C. M., Raghavan, S., & Chen, C. S. (2004) · Tissue Engineering · doi:10.1089/1076327041348365 · Cited by 235 · see citing works

Roles of the cytoskeleton, cell adhesion and rho signalling in mechanosensing and mechanotransduction

Ohashi, K., Fujiwara, S., & Mizuno, K. (2017) · The Journal of Biochemistry · doi:10.1093/jb/mvw082 · Cited by 220 · see citing works

Anomalous preferences of cultured macrophages for hydrophobic and roughened substrata

Rich, A. M., & Harris, A. K. (1981) · Journal of Cell Science · doi:10.1242/jcs.50.1.1 · Cited by 213 · see citing works

Differential regulation of macrophage inflammatory activation by fibrin and fibrinogen

Hsieh, J., Smith, T. D., Meli, V., Trần, T. N. L., Botvinick, E., & Liu, W. F. (2016) · Acta Biomaterialia · doi:10.1016/j.actbio.2016.09.024 · Cited by 206 · see citing works

TRPV4 Mechanosensitive Ion Channel Regulates Lipopolysaccharide-Stimulated Macrophage Phagocytosis

Scheraga, R. G., Abraham, S., Niese, K. A., Southern, B. D., Grove, L. M., Hite, R. D., McDonald, C., Hamilton, T. A., & Olman, M. A. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1501688 · Cited by 202 · see citing works

Epigenetic regulation of macrophage polarization and inflammation by DNA methylation in obesity

Wang, X., Cao, Q., Yu, L., Shi, H., Xue, B., & Shi, H. (2016) · JCI Insight · doi:10.1172/jci.insight.87748 · Cited by 197 · see citing works

Regulation of macrophage polarization and plasticity by complex activation signals

Smith, T. D., Tse, M. J., Read, E. L., & Liu, W. F. (2016) · Integrative Biology · doi:10.1039/c6ib00105j · Cited by 196 · see citing works

Overview of ventilator-induced lung injury mechanisms

Lionetti, V., Recchia, F. A., & Ranieri, V. M. (2005) · Current Opinion in Critical Care · doi:10.1097/00075198-200502000-00013 · Cited by 188 · see citing works

Inhibiting DNA Methylation by 5-Aza-2′-deoxycytidine Ameliorates Atherosclerosis Through Suppressing Macrophage Inflammation

Cao, Q., Wang, X., Jia, L., Mondal, A. K., Diallo, A., Hawkins, G. A., Das, S. K., Parks, J. S., Yu, L., Shi, H., et al. (2014) · Endocrinology · doi:10.1210/en.2014-1595 · Cited by 187 · see citing works

Cardiovascular Protection by ApoE and ApoE-HDL Linked to Suppression of ECM Gene Expression and Arterial Stiffening

Kothapalli, D., Liu, S., Bae, Y., Monslow, J., Xu, T., Hawthorne, E. A., Byfield, F. J., Castagnino, P. A., Rao, S. J., Rader, D. J., et al. (2012) · Cell Reports · doi:10.1016/j.celrep.2012.09.018 · Cited by 186 · see citing works

Exposure to Shear Stress Alters Endothelial Adhesiveness

Tsao, P. S., Lewis, N. P., Alpert, S., & Cooke, J. P. (1995) · Circulation · doi:10.1161/01.cir.92.12.3513 · Cited by 178 · see citing works

Regulation of lamellipodial persistence, adhesion turnover, and motility in macrophages by focal adhesion kinase

Owen, K. A., Pixley, F. J., Thomas, K. S., Vicente‐Manzanares, M., Ray, B. J., Horwitz, A. F., Parsons, J. T., Beggs, H. E., Stanley, E. R., & Bouton, A. H. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200708093 · Cited by 178 · see citing works

Substrate Stiffness Regulates Proinflammatory Mediator Production through TLR4 Activity in Macrophages

Previtera, M. L., & Sengupta, A. (2015) · PLOS ONE · doi:10.1371/journal.pone.0145813 · Cited by 176 · see citing works

Podosome-type adhesions and focal adhesions, so alike yet so different

Block, M. R., Badowski, C., Millon‐Frémillon, A., Bouvard, D., Bouin, A., Faurobert, E., Gerber, D., Planus, E., & Albigès‐Rizo, C. (2008) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2008.02.012 · Cited by 165 · see citing works

Lipopolysaccharide Induces Actin Reorganization and Tyrosine Phosphorylation of Pyk2 and Paxillin in Monocytes and Macrophages

Williams, L. M., & Ridley, A. J. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.4.2028 · Cited by 160 · see citing works

Macrophage migration in fibrin gel matrices.

Ciano, P. S., Colvin, R. B., Dvořàk, A. M., McDonagh, J., & Dvorak, H. F. (1986) · PubMed · Cited by 160 · see citing works

Cadherin adhesome at a glance

Zaidel‐Bar, R. (2013) · Journal of Cell Science · doi:10.1242/jcs.111559 · Cited by 154 · see citing works

The distinct roles of the nucleus and nucleus-cytoskeleton connections in three-dimensional cell migration

Khatau, S. B., Bloom, R. J., Bajpai, S. K., Razafsky, D. S., Zang, S., Giri, A., Wu, P.-H., Marchand, J. A., Celedon, A., Hale, C. M., et al. (2012) · Scientific Reports · doi:10.1038/srep00488 · Cited by 153 · see citing works

The signaling protein Wnt5a promotes TGFβ1-mediated macrophage polarization and kidney fibrosis by inducing the transcriptional regulators Yap/Taz

Feng, Y., Liang, Y., Zhu, X., Wang, M., Gui, Y., Lu, Q., Gu, M., Xue, X., Sun, X., He, W., et al. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.ra118.005457 · Cited by 152 · see citing works

Ovatodiolide suppresses colon tumorigenesis and prevents polarization of M2 tumor-associated macrophages through YAP oncogenic pathways

Huang, Y., Yang, C.-K., Wei, P., Huynh, T.-T., Whang‐Peng, J., Meng, T., Hsiao, M., Tzeng, Y., Wu, A. T. H., & Yen, Y. (2017) · Journal of Hematology & Oncology · doi:10.1186/s13045-017-0421-3 · Cited by 152 · see citing works

Integrin CD11b positively regulates TLR4-induced signalling pathways in dendritic cells but not in macrophages

Ling, G. S., Bennett, J., Woollard, K. J., Szajna, M., Fossati‐Jimack, L., Taylor, P. R., Scott, D. M., Franzoso, G., Cook, H. T., & Botto, M. (2014) · Nature Communications · doi:10.1038/ncomms4039 · Cited by 151 · see citing works

From tissue mechanics to transcription factors

Janmey, P. A., Wells, R. G., Assoian, R. K., & McCulloch, C. A. (2013) · Differentiation · doi:10.1016/j.diff.2013.07.004 · Cited by 149 · see citing works

Self-Organized Podosomes Are Dynamic Mechanosensors

Collin, O., Na, S., Chowdhury, F., Hong, M., Shin, M. E., Wang, F., & Wang, N. (2008) · Current Biology · doi:10.1016/j.cub.2008.07.046 · Cited by 147 · see citing works

Context-dependent switch in chemo/mechanotransduction via multilevel crosstalk among cytoskeleton-regulated MRTF and TAZ and TGFβ-regulated Smad3

Speight, P., Kofler, M., Szászi, K., & Kapus, A. (2016) · Nature Communications · doi:10.1038/ncomms11642 · Cited by 144 · see citing works

Analysis of single-cell cytokine secretion reveals a role for paracrine signaling in coordinating macrophage responses to TLR4 stimulation

Xue, Q., Lu, Y., Eisele, M. R., Sulistijo, E. S., Khan, N., Fan, R., & Miller-Jensen, K. (2015) · Science Signaling · doi:10.1126/scisignal.aaa2155 · Cited by 143 · see citing works

Regulation of Nuclear Translocation of HDAC3 by IκBα Is Required for Tumor Necrosis Factor Inhibition of Peroxisome Proliferator-activated Receptor γ Function

Gao, Z., He, Q., Peng, B., Chiao, P. J., & Ye, J. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m507784200 · Cited by 141 · see citing works

Sensitivity of alveolar macrophages to substrate mechanical and adhesive properties

Féréol, S., Fodil, R., Labat, B., Galiacy, S., Laurent, V. M., Louis, B., Isabey, D., & Planus, E. (2006) · Cell Motility and the Cytoskeleton · doi:10.1002/cm.20130 · Cited by 139 · see citing works

Harnessing macrophage plasticity for tissue regeneration

Smith, T. D., Nagalla, R. R., Chen, E. Y., & Liu, W. F. (2017) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2017.04.012 · Cited by 138 · see citing works

Comparative analysis of integrin expression on monocyte‐derived macrophages and monocyte‐derived dendritic cells

Ammon, C., Meyer, S., Schwarzfischer, L., Krause, S. W., Andreesen, R., & Kreutz, M. P. (2000) · Immunology · doi:10.1046/j.1365-2567.2000.00056.x · Cited by 137 · see citing works

Substrate elasticity regulates the behavior of human monocyte-derived macrophages

Adlerz, K. M., Aranda-Espinoza, H., & Hayenga, H. N. (2016) · European Biophysics Journal · doi:10.1007/s00249-015-1096-8 · Cited by 135 · see citing works

A Role for the αvβ3 Integrin in the Transmigration of Monocytes

Weerasinghe, D., McHugh, K. P., Ross, F. P., Brown, E. J., Gisler, R. H., & Imhof, B. A. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.142.2.595 · Cited by 130 · see citing works

αVβ3 integrin regulates macrophage inflammatory responses via PI3 kinase/Akt‐dependent NF‐κB activation

Antonov, A. S., Antonova, G. N., Munn, D. H., Mivechi, N., Lucas, R., Catravas, J. D., & Verin, A. D. (2011) · Journal of Cellular Physiology · doi:10.1002/jcp.22356 · Cited by 128 · see citing works

Cellular micro-environments reveal defective mechanosensing responses and elevated YAP signaling in LMNA-mutated muscle precursors

Bertrand, A., Ziaei, S., Ehret, C., Duchemin, H., Mamchaoui, K., Bigot, A., Mayer, M., Quijano-Roy, S., Desguerre, I., Lainé, J., et al. (2014) · Journal of Cell Science · doi:10.1242/jcs.144907 · Cited by 126 · see citing works

Interstitial flow promotes macrophage polarization toward an M2 phenotype

Li, R., Serrano, J. C., Xing, H., Lee, T. A., Azizgolshani, H., Zaman, M. H., & Kamm, R. D. (2018) · Molecular Biology of the Cell · doi:10.1091/mbc.e18-03-0164 · Cited by 124 · see citing works

SOCS1 hypermethylation mediated by DNMT1 is associated with lipopolysaccharide-induced inflammatory cytokines in macrophages

Chang, C. K., Huang, C., Ma, T., Bian, E., He, Y., Zhang, L., & Li, J. (2014) · Toxicology Letters · doi:10.1016/j.toxlet.2013.12.023 · Cited by 121 · see citing works

Biomechanical Thresholds Regulate Inflammation through the NF-κB Pathway: Experiments and Modeling

Nam, J., Aguda, B. D., Rath, B., & Agarwal, S. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005262 · Cited by 116 · see citing works

Matrix stiffness and tumor-associated macrophages modulate epithelial to mesenchymal transition of human adenocarcinoma cells

Alonso‐Nocelo, M., Raimondo, T. M., Vining, K. H., López‐López, R., de la Fuente, M., & Mooney, D. J. (2018) · Biofabrication · doi:10.1088/1758-5090/aaafbc · Cited by 115 · see citing works

Dynamic Gene Regulatory Networks of Human Myeloid Differentiation

Ramírez, R. N., El-Ali, N. C., Mager, M. A., Wyman, D., Conesa, A., & Mortazavi, A. (2017) · Cell Systems · doi:10.1016/j.cels.2017.03.005 · Cited by 114 · see citing works

Macrophage migration in fibrin gel matrices. II. Effects of clotting factor XIII, fibronectin, and glycosaminoglycan content on cell migration.

Lanir, N., Ciano, P. S., Water, L. V. D., McDonagh, J., Dvořàk, A. M., & Dvorak, H. F. (1988) · The Journal of Immunology · doi:10.4049/jimmunol.140.7.2340 · Cited by 113 · see citing works

Analysis on migration and activation of live macrophages on transparent flat and nanostructured titanium

Lee, S., Choi, J., Shin, S., Im, Y.-M., Song, J., Kang, S. S., Nam, T.-H., Webster, T. J., Kim, S.-H., & Khang, D. (2011) · Acta Biomaterialia · doi:10.1016/j.actbio.2011.01.006 · Cited by 108 · see citing works

Deconstructing the nucleus: global architecture from local interactions

Marshall, W. F., Fung, J. C., & Sedat, J. W. (1997) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(97)80136-0 · Cited by 108 · see citing works

Modulus-dependent macrophage adhesion and behavior

Irwin, E. F., Saha, K., Rosenbluth, M., Gamble, L. J., Castner, D. G., & Healy, K. E. (2008) · Journal of Biomaterials Science, Polymer Edition · doi:10.1163/156856208786052407 · Cited by 105 · see citing works

An Essential Role for Talin during α M β 2 -mediated Phagocytosis

Lim, J., Wiedemann, A., Tzircotis, G., Monkley, S. J., Critchley, D. R., & Caron, E. (2007) · Molecular Biology of the Cell · doi:10.1091/mbc.e06-09-0813 · Cited by 104 · see citing works

Granulocyte-macrophage and macrophage colony-stimulating factors differentially regulate alpha v integrin expression on cultured human macrophages.

Nichilo, M. O. D., & Burns, G. F. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.6.2517 · Cited by 101 · see citing works

Mechanotransduction and nuclear function

Graham, D. M., & Burridge, K. (2016) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2016.03.006 · Cited by 101 · see citing works

Myeloid‐derived suppressor cells: Roles in the tumor microenvironment and tumor radiotherapy

Yin, Z., Li, C., Wang, J., & Xue, L. (2018) · International Journal of Cancer · doi:10.1002/ijc.31744 · Cited by 100 · see citing works

The LINC-less granulocyte nucleus

Olins, A. L., Hoang, T. V., Zwerger, M., Herrmann, H. O., Zentgraf, H., Noegel, A. A., Karakesisoglou, I., Hodzic, D. M., & Olins, D. E. (2008) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2008.10.001 · Cited by 100 · see citing works

Foreign body giant cell formation is preceded by lamellipodia formation and can be attenuated by inhibition of Rac1 activation

Jay, S. M., Skokos, E., Laiwalla, F., Krady, M.-M., & Kyriakides, T. R. (2007) · The American Journal of Pathology · doi:10.2353/ajpath.2007.061213 · Cited by 92 · see citing works

Epigenetic Mechanism in Regulation of Endothelial Function by Disturbed Flow: Induction of DNA Hypermethylation by DNMT1

Zhou, J., Li, Y.-S. J., Wang, K.-C., & Chien, S. (2014) · Cellular and Molecular Bioengineering · doi:10.1007/s12195-014-0325-z · Cited by 90 · see citing works

Rho is a negative regulator of human monocyte spreading

Aepfelbacher, M., Essler, M., Huber, E., Czech, A., & Weber, P. (1996) · The Journal of Immunology · doi:10.4049/jimmunol.157.11.5070 · Cited by 89 · see citing works

Induction of specific macrophage subtypes by defined micro-patterned structures

Bartneck, M., Schulte, V. A., Paul, N. E., Diez, M., Lensen, M. C., & Zwadlo-Klarwasser, G. (2010) · Acta Biomaterialia · doi:10.1016/j.actbio.2010.04.025 · Cited by 87 · see citing works

Physiologic cyclic stretch inhibits apoptosis in vascular endothelium

Liu, X., Ensenat, D., Wang, H., Schafer, A. I., & Durante, W. (2003) · FEBS Letters · doi:10.1016/s0014-5793(03)00285-0 · Cited by 86 · see citing works

Macrophage response to microtextured silicone

Schmidt, J. A., & von Recum, A. F. (1992) · Biomaterials · doi:10.1016/0142-9612(92)90138-e · Cited by 84 · see citing works

Microdeformation of Three-Dimensional Cultured Fibroblasts Induces Gene Expression and Morphological Changes

Lu, F. Z., Ogawa, R., Nguyen, D. T., Chen, B., Guo, D., Helm, D. L., Zhan, Q., Murphy, G. F., & Orgill, D. P. (2011) · Annals of Plastic Surgery · doi:10.1097/sap.0b013e3181ea1e9b · Cited by 83 · see citing works

Role of the nuclear envelope in genome organization and gene expression

de Vosse, D. W. V., Wan, Y., Wozniak, R. W., & Aitchison, J. D. (2010) · WIREs Systems Biology and Medicine · doi:10.1002/wsbm.101 · Cited by 81 · see citing works

MRTF-A mediates LPS-induced pro-inflammatory transcription by interacting with the COMPASS complex

Yu, L., Weng, X., Liang, P., Dai, X., Wu, X.-Y., Xu, H., Fang, M., Fang, F., & Xu, Y. (2014) · Journal of Cell Science · doi:10.1242/jcs.152314 · Cited by 81 · see citing works

Topographical modulation of macrophage phenotype by shrink-film multi-scale wrinkles

Wang, T., Luu, T. U., Chen, A., Khine, M., & Liu, W. F. (2016) · Biomaterials Science · doi:10.1039/c6bm00224b · Cited by 77 · see citing works

Brief Reports: TRPM7 Senses Mechanical Stimulation Inducing Osteogenesis in Human Bone Marrow Mesenchymal Stem Cells

Xiao, E., Yang, H.-Q., Gan, Y., Duan, D., He, L., Guo, Y., Wang, S., & Zhang, Y. (2014) · Stem Cells · doi:10.1002/stem.1858 · Cited by 75 · see citing works

Anti-inflammatory effect of Trichostatin-A on murine bone marrow-derived macrophages

Han, S., & Lee, J. K. (2009) · Archives of Pharmacal Research · doi:10.1007/s12272-009-1418-4 · Cited by 71 · see citing works

TRPC6 channel translocation into phagosomal membrane augments phagosomal function

Riazanski, V., Gabdoulkhakova, A. G., Boynton, L. S., Eguchi, R. R., Deriy, L. V., Hogarth, D. K., Loaëc, N., Oumata, N., Galons, H., Brown, M. E., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1518966112 · Cited by 70 · see citing works

Mechanoregulation of Angiogenesis in Wound Healing

Lancerotto, L., & Orgill, D. P. (2014) · Advances in Wound Care · doi:10.1089/wound.2013.0491 · Cited by 68 · see citing works

Macrophage motility is driven by frontal-towing with a force magnitude dependent on substrate stiffness

Hind, L. E., Dembo, M., & Hammer, D. A. (2015) · Integrative Biology · doi:10.1039/c4ib00260a · Cited by 67 · see citing works

A complex flow pattern of low shear stress and flow reversal promotes monocyte binding to endothelial cells

Honda, H. M. (2001) · Atherosclerosis · doi:10.1016/s0021-9150(01)00462-2 · Cited by 66 · see citing works

The Effect of Mechanical Loading Upon Extracellular Matrix Bioscaffold-Mediated Skeletal Muscle Remodeling

Dziki, J. L., Giglio, R. M., Sicari, B. M., Wang, D. S., Gandhi, R. M., Londono, R., Dearth, C. L., & Badylak, S. F. (2018) · Tissue Engineering Part A · doi:10.1089/ten.tea.2017.0011 · Cited by 61 · see citing works

TRPV4 calcium-permeable channel is a novel regulator of oxidized LDL-induced macrophage foam cell formation

Goswami, R., Merth, M., Sharma, S., Alharbi, M. O., Aranda‐Espinoza, H., Zhu, X., & Rahaman, S. O. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2017.06.004 · Cited by 60 · see citing works

Characterization of the Flexcell™ Uniflex™ cyclic strain culture system with U937 macrophage-like cells

Matheson, L. A., Fairbank, N. J., Maksym, G. N., Santerre, J. P., & Labow, R. S. (2005) · Biomaterials · doi:10.1016/j.biomaterials.2005.05.070 · Cited by 59 · see citing works

The role of integrin αDβ2 (CD11d/CD18) in monocyte/macrophage migration

Yakubenko, V. P., Nataly, B., Mishchuk, D., Aleksey, S., Lam, S. C.-T., & Ugarova, T. P. (2008) · Experimental Cell Research · doi:10.1016/j.yexcr.2008.05.016 · Cited by 59 · see citing works

Unbiased Analysis of the Impact of Micropatterned Biomaterials on Macrophage Behavior Provides Insights beyond Predefined Polarization States

Singh, S., Awuah, D., Rostam, H. M., Emes, R. D., Kandola, N. K., Onion, D., Htwe, S. S., Rajchagool, B., Cha, B.-H., Kim, D. J., et al. (2017) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.7b00104 · Cited by 51 · see citing works

Macrophage Lamin A/C Regulates Inflammation and the Development of Obesity-Induced Insulin Resistance

Kim, Y., Bayona, P. W., Kim, M., Chang, J., Hong, S., Park, Y., Budiman, A., Kim, Y. J., Choi, C. Y., Kim, W. S., et al. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00696 · Cited by 50 · see citing works

Progressive changes of elastic moduli of arterial wall and atherosclerotic plaque components during plaque development in human coronary arteries

Rezvani-Sharif, A., Tafazzoli‐Shadpour, M., & Avolio, A. P. (2018) · Medical & Biological Engineering & Computing · doi:10.1007/s11517-018-1910-4 · Cited by 50 · see citing works

Rac2 Specificity in Macrophage Integrin Signaling

Pradip, D., Peng, X., & Durden, D. L. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m306491200 · Cited by 49 · see citing works

Mechanosensitive Ca2+-permeable channels in human leukemic cells: Pharmacological and molecular evidence for TRPV2

Pottosin, I. I., Delgado‐Enciso, I., Bonales-Alatorre, E. O., Pescador, M. G. N., Moreno-Galindo, E. G., & Dobrovinskaya, O. R. (2014) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2014.09.008 · Cited by 48 · see citing works

Nuclear transport of the serum response factor coactivator MRTF‐A is downregulated at tensional homeostasis

McGee, K., Vartiainen, M. K., Khaw, P. T., Treisman, R., & Bailly, M. (2011) · EMBO Reports · doi:10.1038/embor.2011.141 · Cited by 47 · see citing works

The nuclear lamina and heterochromatin: a complex relationship

Bank, E. M., & Gruenbaum, Y. (2011) · Biochemical Society Transactions · doi:10.1042/bst20110603 · Cited by 44 · see citing works

Activation of NF-κB by fluid shear stress, but not TNF-α, requires focal adhesion kinase in osteoblasts

Young, S. R. L., Gerard-O’Riley, R. L., Harrington, M. A., & Pavalko, F. M. (2010) · Bone · doi:10.1016/j.bone.2010.03.014 · Cited by 42 · see citing works

The effect of surface topography on cell shape and early ERK1/2 signaling in macrophages; linkage with FAK and Src

Ghrebi, S., Hamilton, D. W., Waterfield, J. D., & Brunette, D. M. (2013) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.34509 · Cited by 41 · see citing works

Deacetylase inhibitors repress STAT5-mediated transcription by interfering with bromodomain and extra-terminal (BET) protein function

Pinz, S., Unser, S., Buob, D., Fischer, P., Jobst, B., & Rascle, A. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv188 · Cited by 38 · see citing works

The Hv1 proton channel responds to mechanical stimuli

Pathak, M. M., Tran, T. T., Hong, L., Joós, B., Morris, C. E., & Tombola, F. (2016) · The Journal of General Physiology · doi:10.1085/jgp.201611672 · Cited by 38 · see citing works

The effect of surface topography on early NFκB signaling in macrophages

Waterfield, J. D., Ali, T. A., Nahid, F., Kusano, K., & Brunette, D. M. (2010) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.32857 · Cited by 38 · see citing works

Activation of p38 MAPKα by extracellular pressure mediates the stimulation of macrophage phagocytosis by pressure

Shiratsuchi, H., & Basson, M. D. (2004) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00543.2004 · Cited by 35 · see citing works

Effect of Uniaxial, Cyclic Stretch on the Morphology of Monocytes/Macrophages in Culture

MATSUMOTΟ, T., Delafontaine, P., Schnetzer, K. J., Tong, B. C., & Nerem, R. M. (1996) · Journal of Biomechanical Engineering · doi:10.1115/1.2796026 · Cited by 34 · see citing works

Focal Adhesion Kinase Upregulated by Granulocyte-Macrophage Colony-Stimulating Factor But Not by Interleukin-3 in Differentiating Myeloid Cells

Kume, A., Nishiura, H., Suda, J., & Suda, T. (1997) · Blood · doi:10.1182/blood.v89.9.3434 · Cited by 29 · see citing works

Regulation of Macrophages by Extracellular Matrix Composition and Adhesion Geometry

Luu, T. U., & Liu, W. F. (2018) · Regenerative Engineering and Translational Medicine · doi:10.1007/s40883-018-0065-z · Cited by 29 · see citing works

A Low-Cost Mechanical Stretching Device for Uniaxial Strain of Cells: A Platform for Pedagogy in Mechanobiology

Atcha, H., Davis, C. T., Sullivan, N. R., Smith, T. D., Anis, S., Dahbour, W. Z., Robinson, Z. R., Grosberg, A., & Liu, W. F. (2018) · Journal of Biomechanical Engineering · doi:10.1115/1.4039949 · Cited by 28 · see citing works

Effects of extracellular matrix proteins on macrophage differentiation, growth, and function: Comparison of liquid and agar culture systems

Armstrong, J. W., & Chapes, S. K. (1994) · Journal of Experimental Zoology · doi:10.1002/jez.1402690303 · Cited by 19 · see citing works

Combined stimulation with cyclic stretching and hypoxia increases production of matrix metalloproteinase-9 and cytokines by macrophages

Oya, K., Sakamoto, N., OHASHI, T., & Sato, M. (2011) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2011.08.024 · Cited by 18 · see citing works

Lipid Rafts Direct Macrophage Motility in the Tissue Microenvironment

Previtera, M. L., Peterman, K., Shah, S. K., & Luzuriaga, J. (2014) · Annals of Biomedical Engineering · doi:10.1007/s10439-014-1142-1 · Cited by 11 · see citing works

Mechanical and structural assessment of cortical and deep cytoskeleton reveals substrate-dependent alveolar macrophage remodeling.

Féréol, S., Fodil, R., Laurent, V. M., Planus, E., Louis, B., Pelle, G., & Isabey, D. (2008) · PubMed · Cited by 9 · see citing works

Mechanotransduction to Epigenetic Remodeling

Kelkhoff, D. O., Downing, T. L., & Li, S. (2016) · Springer eBooks · doi:10.1007/978-1-4939-5617-3_8 · Cited by 6 · see citing works

Macrophages in immunoregulation and therapeutics

Chen, S., Saeed, A. F. U. H., Liu, Q., Jiang, Q., Xu, H., Xiao, G. G., Rao, L., & Duo, Y. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01452-1 · Cited by 2,348 · see citing works

Mechanically activated ion channel Piezo1 modulates macrophage polarization and stiffness sensing

Atcha, H., Jairaman, A., Holt, J. R., Meli, V. S., Nagalla, R. R., Veerasubramanian, P. K., Brumm, K. T., Lim, H. E., Othy, S., Cahalan, M. D., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-23482-5 · Cited by 644 · see citing works

The extracellular matrix and the immune system: A mutually dependent relationship

Sutherland, T. E., Dyer, D. P., & Allen, J. E. (2023) · Science · doi:10.1126/science.abp8964 · Cited by 519 · see citing works

Tuning immunity through tissue mechanotransduction

Du, H., Bartleson, J. M., Butenko, S., Alonso, V., Liu, W. F., Winer, D. A., & Butte, M. J. (2022) · Nature reviews. Immunology · doi:10.1038/s41577-022-00761-w · Cited by 435 · see citing works

Tailoring Materials for Modulation of Macrophage Fate

Li, J., Jiang, X., Li, H., Gelinsky, M., & Gu, Z. (2021) · Advanced Materials · doi:10.1002/adma.202004172 · Cited by 402 · see citing works

YAP-mediated mechanotransduction tunes the macrophage inflammatory response

Meli, V. S., Atcha, H., Veerasubramanian, P. K., Nagalla, R. R., Luu, T. U., Chen, E. Y., Guerrero-Juarez, C. F., Yamaga, K., Pandori, W., Hsieh, J. Y., et al. (2020) · Science Advances · doi:10.1126/sciadv.abb8471 · Cited by 329 · see citing works

Hydrogel crosslinking modulates macrophages, fibroblasts, and their communication, during wound healing

Butenko, S., Nagalla, R. R., Guerrero‐Juarez, C. F., Palomba, F., David, L.-M., Nguyen, R. Q., Gay, D. L., Almet, A. A., Digman, M. A., Nie, Q., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-50072-y · Cited by 221 · see citing works

Mechanisms of Vascular Remodeling in Hypertension.

Humphrey, J. (2020) · American Journal of Hypertension · doi:10.1093/ajh/hpaa195 · Cited by 168 · see citing works

Precisely defined fiber scaffolds with 40 μm porosity induce elongation driven M2-like polarization of human macrophages

Tylek, T., Blum, C., Hrynevich, A., Schlegelmilch, K., Schilling, T., Dalton, P. D., & Groll, J. (2020) · Biofabrication · doi:10.1088/1758-5090/ab5f4e · Cited by 161 · see citing works

Unraveling the mechanobiology of immune cells

Zhang, X., Kim, T.-H., Thauland, T. J., Li, H., Majedi, F. S., Ly, C., Gu, Z., Butte, M. J., Rowat, A. C., & Li, S. (2020) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2020.09.004 · Cited by 119 · see citing works

Mechanosensing in macrophages and dendritic cells in steady-state and disease

Lee, M., Du, H., Winer, D. A., Clemente-Casares, X., & Tsai, S. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.1044729 · Cited by 99 · see citing works

Biomaterials-Mediated Regulation of Macrophage Cell Fate

Liu, Y., & Segura, T. (2020) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2020.609297 · Cited by 92 · see citing works

Stretching the Function of Innate Immune Cells

Orsini, E. M., Perelas, A., Southern, B. D., Grove, L. M., Olman, M. A., & Scheraga, R. G. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.767319 · Cited by 91 · see citing works

Phosphatidylserine liposome multilayers mediate the M1-to-M2 macrophage polarization to enhance bone tissue regeneration

Toita, R., Kang, J., & Tsuchiya, A. (2022) · Acta Biomaterialia · doi:10.1016/j.actbio.2022.10.024 · Cited by 90 · see citing works

Ion channel Piezo1 activation promotes aerobic glycolysis in macrophages

Leng, S., Zhang, X., Wang, S., Qin, J., Liu, Q., Liu, A., Sheng, Z., Feng, Q., Hu, X., & Peng, J. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.976482 · Cited by 88 · see citing works

When things go wrong: exploring possible mechanisms driving the progressive fibrosis phenotype in interstitial lung diseases

Selman, M., & Pardo, A. (2021) · European Respiratory Journal · doi:10.1183/13993003.04507-2020 · Cited by 91 · see citing works

Unmasking the Many Faces of Tumor-Associated Neutrophils and Macrophages: Considerations for Targeting Innate Immune Cells in Cancer

Keeley, T. S., Costanzo-Garvey, D. L., & Cook, L. M. (2019) · Trends in cancer · doi:10.1016/j.trecan.2019.10.013 · Cited by 83 · see citing works

Biomaterial-mediated macrophage polarization remodeling and sequential regulation: a potential strategy in bone infections treatment

Shi, X., Xu, C., Chen, Z., Li, M., Yin, Z., Wang, B., Li, Y., Wu, Y., Wu, X., & Xu, Y. (2025) · Bone Research · doi:10.1038/s41413-025-00471-8 · Cited by 75 · see citing works

Modeling mechanical activation of macrophages during pulmonary fibrogenesis for targeted anti-fibrosis therapy

Xu, Y., Ying, L., Lang, J. K., Hinz, B., & Zhao, R. (2024) · Science Advances · doi:10.1126/sciadv.adj9559 · Cited by 67 · see citing works

Macrophage–stroma interactions in fibrosis: biochemical, biophysical, and cellular perspectives

Vasse, G. F., Nizamoglu, M., Heijink, I. H., Schlepütz, M., van Rijn, P., Thomas, M. J., Burgess, J. K., & Melgert, B. N. (2021) · The Journal of Pathology · doi:10.1002/path.5632 · Cited by 66 · see citing works

Translation of Collagen Ultrastructure to Biomaterial Fabrication for Material‐Independent but Highly Efficient Topographic Immunomodulation

Ryma, M., Tylek, T., Liebscher, J., Blum, C., fernandez, R., böhm, C., Kastenmüller, W., Gasteiger, G., & Gröll, J. (2021) · Advanced Materials · doi:10.1002/adma.202101228 · Cited by 67 · see citing works

Mechanosensation to inflammation: Roles for YAP/TAZ in innate immune cells

Meli, V. S., Veerasubramanian, P. K., Downing, T. L., Wang, W., & Liu, W. F. (2023) · Science Signaling · doi:10.1126/scisignal.adc9656 · Cited by 72 · see citing works

Can’t handle the stress? Mechanobiology and disease

Zuela-Sopilniak, N., & Lammerding, J. (2022) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2022.05.010 · Cited by 59 · see citing works

Decellularized scaffold and its elicited immune response towards the host: The underlying mechanism and means of immunomodulatory modification

Tan, J., Zhang, Q.-Y., Huang, L.-P., Huang, K., & Xie, H.-Q. (2021) · Biomaterials Science · doi:10.1039/d1bm00470k · Cited by 57 · see citing works

The Iron Curtain: Macrophages at the Interface of Systemic and Microenvironmental Iron Metabolism and Immune Response in Cancer

DeRosa, A., & Leftin, A. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.614294 · Cited by 55 · see citing works

Fibroblast Yap/Taz Signaling in Extracellular Matrix Homeostasis and Tissue Fibrosis

Chu, C., & Quan, T. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13123358 · Cited by 59 · see citing works

Dwellers and Trespassers: Mononuclear Phagocytes at the Borders of the Central Nervous System

Ivan, D. C., Walthert, S., Berve, K., Steudler, J., & Locatelli, G. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2020.609921 · Cited by 53 · see citing works

Exosome loaded immunomodulatory biomaterials alleviate local immune response in immunocompetent diabetic mice post islet xenotransplantation

Mohammadi, M. R., Rodriguez, S. M., Luong, J. C., Li, S., Cao, R., Alshetaiwi, H., Lau, H., Davtyan, H., Jones, M. B., Jafari, M., et al. (2021) · Communications Biology · doi:10.1038/s42003-021-02229-4 · Cited by 53 · see citing works

Biomedical Implants with Charge‐Transfer Monitoring and Regulating Abilities

Wang, D., Tan, J., Zhu, H., Mei, Y., & Liu, X. (2021) · Advanced Science · doi:10.1002/advs.202004393 · Cited by 49 · see citing works

Treating Autoimmune Inflammatory Diseases with an siERN1-Nanoprodrug That Mediates Macrophage Polarization and Blocks Toll-like Receptor Signaling

Feng, N., Li, L., Fan, M., Du, Y., Chen, C., Jiang, R., Yu, D., Yang, Y., Zhang, M., Deng, L., et al. (2021) · ACS Nano · doi:10.1021/acsnano.1c03726 · Cited by 45 · see citing works

Mobile mechanical signal generator for macrophage polarization

Jiang, J., Wang, F., Huang, W., Sun, J., Ye, Y., Ou, J., Liu, M., Gao, J., Wang, S., Fu, D., et al. (2023) · Exploration · doi:10.1002/exp.20220147 · Cited by 37 · see citing works

Polarization behavior of bone marrow-derived macrophages on charged P(VDF-TrFE) coatings

Wang, Z., He, X., Tang, B., Chen, X., Dong, L., Cheng, K., & Weng, W. (2020) · Biomaterials Science · doi:10.1039/d0bm01604g · Cited by 38 · see citing works

The Role of Autophagy in M2 Polarization of Macrophages Induced by Micro/Nano Topography

Luo, J., He, Y., Meng, F., Yan, N., Zhang, Y., & Song, W. (2020) · International Journal of Nanomedicine · doi:10.2147/ijn.s270100 · Cited by 36 · see citing works

Neutrophil extracellular traps primed intercellular communication in cancer progression as a promising therapeutic target

Shang, B., Cui, H., Xie, R., Wu, J., Shi, H., Bi, X., Feng, L., & Shou, J. (2023) · Biomarker Research · doi:10.1186/s40364-023-00463-y · Cited by 33 · see citing works

Assessing the response of human primary macrophages to defined fibrous architectures fabricated by melt electrowriting

Mondadori, C., Chandrakar, A., Lopa, S., Wieringa, P. A., Talò, G., Perego, S., Lombardi, G., Colombini, A., Moretti, M., & Moroni, L. (2022) · Bioactive Materials · doi:10.1016/j.bioactmat.2022.07.014 · Cited by 32 · see citing works

N6-methyladenosine of Socs1 modulates macrophage inflammatory response in different stiffness environments

Hu, Z., Li, Y., Yuan, W., Jin, L., Leung, W. K., Zhang, C., & Yang, Y. (2022) · International Journal of Biological Sciences · doi:10.7150/ijbs.74196 · Cited by 31 · see citing works

Human In Vitro Model Mimicking Material‐Driven Vascular Regeneration Reveals How Cyclic Stretch and Shear Stress Differentially Modulate Inflammation and Matrix Deposition

van Haaften, E. E., Wissing, T. B., Kurniawan, N. A., Smits, A. I. P. M., & Bouten, C. V. C. (2020) · Advanced Biosystems · doi:10.1002/adbi.201900249 · Cited by 30 · see citing works

Nuclear transport of STAT6 determines the matrix rigidity dependent M2 activation of macrophages

Kim, J.-K., Han, S., Park, S. I., Kim, I., & Kim, D. (2022) · Biomaterials · doi:10.1016/j.biomaterials.2022.121859 · Cited by 30 · see citing works

A Src-H3 acetylation signaling axis integrates macrophage mechanosensation with inflammatory response

Veerasubramanian, P. K., Shao, H., Meli, V. S., Phan, T. A. Q., Luu, T. U., Liu, W. F., & Downing, T. L. (2021) · Biomaterials · doi:10.1016/j.biomaterials.2021.121236 · Cited by 28 · see citing works

Overlooked <i>Candida glabrata</i> petites are echinocandin tolerant, induce host inflammatory responses, and display poor <i>in vivo</i> fitness

Arastehfar, A., Daneshnia, F., Hovhannisyan, H., Fuentes, D., Cabrera, N., Quinteros, C., Ilkit, M., Ünal, N., Hilmioğlu-Polat, S., Jabeen, K., et al. (2023) · mBio · doi:10.1128/mbio.01180-23 · Cited by 27 · see citing works

Immunity in motion: The role of mechanics in macrophage biology

Khanmohammadi, M., Mirzaalikhan, Y., & Baratchi, S. (2025) · Cell chemical biology · doi:10.1016/j.chembiol.2025.11.004 · Cited by 28 · see citing works

M1-polarized macrophage-derived cellular nanovesicle-coated lipid nanoparticles for enhanced cancer treatment through hybridization of gene therapy and cancer immunotherapy

Shin, H. E., Han, J., Shin, S., Bae, G., Son, B., Kim, T., Park, H. H., Park, C. G., & Park, W. (2024) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2024.03.004 · Cited by 27 · see citing works

MiR-132-3p Modulates MEKK3-Dependent NF-κB and p38/JNK Signaling Pathways to Alleviate Spinal Cord Ischemia-Reperfusion Injury by Hindering M1 Polarization of Macrophages

Hua, F., Li, H., Pan, Q., Jin, H., Yang, M., Wang, R., Wang, Q.-Y., & Zhang, J. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.570451 · Cited by 26 · see citing works

Modulation of macrophages by biophysical cues in health and beyond

Wilson, H. M. (2023) · Discovery Immunology · doi:10.1093/discim/kyad013 · Cited by 26 · see citing works

Anti-Cancer Activity Profiling of Chemotherapeutic Agents in 3D Co-Cultures of Pancreatic Tumor Spheroids with Cancer-Associated Fibroblasts and Macrophages

Jang, S.-D., Song, J., Kim, H., Im, C., Khawar, I. A., Park, J. K., & Kuh, H. (2021) · Cancers · doi:10.3390/cancers13235955 · Cited by 24 · see citing works

Extracellular matrix of early pulmonary fibrosis modifies the polarization of alveolar macrophage

Zhang, Y., Zhu, L., Hong, J., & Chen, C. (2022) · International Immunopharmacology · doi:10.1016/j.intimp.2022.109179 · Cited by 25 · see citing works

Modulation of Stiffness-Dependent Macrophage Inflammatory Responses by Collagen Deposition

Meli, V. S., Rowley, A. T., Veerasubramanian, P. K., Heedy, S., Liu, W. F., & Wang, S. (2024) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.3c01892 · Cited by 23 · see citing works

Osteointegration of Ti Bone Implants: A Study on How Surface Parameters Control the Foreign Body Response

Restrepo, A. M., Byers, E., Brown, J. L., Patiño, J. F. R., Allain, J. P., & Posada, V. M. (2024) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.4c00114 · Cited by 24 · see citing works

Methyl Gallate Alleviates Acute Ulcerative Colitis by Modulating Gut Microbiota and Inhibiting TLR4/NF-κB Pathway

Zhou, P., Lai, J., Li, Y., Deng, J., Zhao, C., Huang, Q., Yang, F., Yang, S., Wu, Y., Tang, X., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232214024 · Cited by 24 · see citing works

Immunomodulatory Effects of Microcin C7 in Cyclophosphamide-Induced Immunosuppressed Mice

Dai, Z.-Q., Shang, L., Wei, Y.-S., Li, Z.-Q., Zeng, X.-F., Chen, M., Wang, X.-Y., Li, S., Qiao, S., & Yu, H. (2023) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.3c01033 · Cited by 23 · see citing works

Manipulating immune activity of macrophages: a materials and mechanics perspective

Clevenger, A. J., Jha, A., Moore, E., & Raghavan, S. A. (2024) · Trends in biotechnology · doi:10.1016/j.tibtech.2024.07.009 · Cited by 21 · see citing works

Complementary roles of mechanotransduction and inflammation in vascular homeostasis

Latorre, M., Spronck, B., & Humphrey, J. D. (2021) · Proceedings of the Royal Society A Mathematical Physical and Engineering Sciences · doi:10.1098/rspa.2020.0622 · Cited by 21 · see citing works

Hippo/yes-associated protein signaling functions as a mechanotransducer in regulating vascular homeostasis

Lv, H., & Ai, D. (2021) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2021.09.007 · Cited by 23 · see citing works

Surfactin from Bacillus subtilis enhances immune response and contributes to the maintenance of intestinal microbial homeostasis

Jia, J., Fu, M., Ji, W., Xiong, N., Chen, P., Lin, J., & Yang, Q. (2024) · Microbiology Spectrum · doi:10.1128/spectrum.00918-24 · Cited by 21 · see citing works

Cell volume regulation modulates macrophage-related inflammatory responses via JAK/STAT signaling pathways

Yang, X., Wang, Q., Shao, F., Zhuang, Z., Wei, Y., Zhang, L., Zhang, L., Ren, C., & Wang, H. (2024) · Acta Biomaterialia · doi:10.1016/j.actbio.2024.07.046 · Cited by 20 · see citing works

The Molecular Mechanism of Macrophages in Response to Mechanical Stress

Su, Y., & Yin, X. (2024) · Annals of Biomedical Engineering · doi:10.1007/s10439-024-03616-8 · Cited by 20 · see citing works

Chirality Regulates Bone Regeneration through Mechanoresponse and Immunoregulation

Lou, T., Wang, X., Li, J., Wang, W., Han, P., Yu, S., Fan, C., Zhou, C. H., & Ruan, H. (2025) · ACS Nano · doi:10.1021/acsnano.4c13164 · Cited by 20 · see citing works

Density dependent regulation of inflammatory responses in macrophages

Vaughan-Jackson, A., Stodolak, S., Ebrahimi, K. H., Johnson, E., Reardon, P. K., Dupont, M., Zhang, S., McCullagh, J., & James, W. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.895488 · Cited by 19 · see citing works

Single Cell Reactomics: Real‐Time Single‐Cell Activation Kinetics of Optically Trapped Macrophages

Vasse, G. F., Buzón, P., Melgert, B. N., Roos, W. H., & van Rijn, P. (2021) · Small Methods · doi:10.1002/smtd.202000849 · Cited by 19 · see citing works

Light-powered phagocytic macrophage microrobot (phagobot): both in vitro and in vivo

Li, X., Zhong, S., Pan, T., Xiong, J., Zhu, G., Shi, Y., & Xin, H. (2025) · Light Science & Applications · doi:10.1038/s41377-025-01881-3 · Cited by 18 · see citing works

Programming Colloidal Self-Assembled Patterns (cSAPs) into Thermo-Responsible Hybrid Surfaces for Controlling Human Stem Cells and Macrophages

Deng, K., Du, P., Liu, K., Tao, X., Harati, J., Jhang, J.-W., Kim, J., & Wang, P. (2021) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.1c02969 · Cited by 19 · see citing works

Single‐Cell Mechanical Characterization of Human Macrophages

Evers, T. M. J., Sheikhhassani, V., Tang, H., Haks, M. C., Ottenhoff, T. H. M., & Mashaghi, A. (2022) · Advanced NanoBiomed Research · doi:10.1002/anbr.202100133 · Cited by 18 · see citing works

Titania nanospikes activate macrophage phagocytosis by ligand-independent contact stimulation

Kartikasari, N., Yamada, M., Watanabe, J., Tiskratok, W., He, X., & Egusa, H. (2022) · Scientific Reports · doi:10.1038/s41598-022-16214-2 · Cited by 18 · see citing works

The intracellular signaling pathways governing macrophage activation and function in human atherosclerosis

Wilson, H. M. (2022) · Biochemical Society Transactions · doi:10.1042/bst20220441 · Cited by 18 · see citing works

Mechanoimmunology: Are inflammatory epigenetic states of macrophages tuned by biophysical factors?

Jain, N., Lord, J. M., & Viola Vogel, B. (2022) · APL Bioengineering · doi:10.1063/5.0087699 · Cited by 17 · see citing works

Dynamically Reconstructed Collagen Fibers for Transmitting Mechanical Signals to Assist Macrophages Tracing Breast Cancer Cells

Chen, Y., Wang, X., Xie, R., Zhang, Y., Xia, T., Lu, Y. Y., Ye, F., Zhang, P., Cao, T., Xu, Y., et al. (2022) · Advanced Functional Materials · doi:10.1002/adfm.202211807 · Cited by 16 · see citing works

Matrix‐Rigidity Cooperates With Biochemical Cues in M2 Macrophage Activation Through Increased Nuclear Deformation and Chromatin Accessibility

Shin, S. J., Bayarkhangai, B., Tsogtbaatar, K., Yuxuan, M., Kim, S., Kim, Y., Taghizadeh, A., Kim, D., Kim, D., Lee, J., et al. (2025) · Advanced Science · doi:10.1002/advs.202403409 · Cited by 15 · see citing works

Novel 3-D Macrophage Spheroid Model Reveals Reciprocal Regulation of Immunomechanical Stress and Mechano-Immunological Response

Burchett, A. A., Siri, S., Li, J., Lü, X., & Datta, M. (2024) · Cellular and Molecular Bioengineering · doi:10.1007/s12195-024-00824-z · Cited by 15 · see citing works

Engineering macrophages for cancer immunotherapy: emerging insights and therapeutic potential

Block, A. V., Liu, X., Zhang, D., & Adebowale, K. (2026) · npj Biomedical Innovations. · doi:10.1038/s44385-026-00072-y · Cited by 16 · see citing works

PCLLA-nanoHA Bone Substitute Promotes M2 Macrophage Polarization and Improves Alveolar Bone Repair in Diabetic Environments

Wang, D., Wei, L., Hao, J., Tang, W., Zhou, Y., Zhang, C., & Wang, J. (2023) · Journal of Functional Biomaterials · doi:10.3390/jfb14110536 · Cited by 17 · see citing works

Mechanical communication and function regulation of immune cells

Chen, Y., Xie, R., Cao, T., Zhang, Y., Wang, X., Xu, Y., Fan, Q., & Ye, F. (2024) · Fundamental Research · doi:10.1016/j.fmre.2024.04.008 · Cited by 14 · see citing works

Congestion Enriches Intra-hepatic Macrophages Through Reverse Zonation of CXCL9 in Liver Sinusoidal Endothelial Cells

Ma, S., Habash, N. W., Dehankar, M. K., Jalan‐Sakrikar, N., Cooper, S. A., Anwar, A. A., Jerez, S., Sutthirat, P., Gao, J., Diamond, T., et al. (2025) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2025.101475 · Cited by 13 · see citing works

Effects of nanoparticle physicochemical properties on macrophage polarization

Lin, H., Li, Z., Zelepukin, I. V., Deyev, S. M., Yang, X., & Li, Z. (2025) · Journal of Controlled Release · doi:10.1016/j.jconrel.2025.114215 · Cited by 13 · see citing works

Engineering dynamic hydrogels to overcome translational bottlenecks in therapeutic delivery

Pashuck, E. T. (2026) · Journal of Controlled Release · doi:10.1016/j.jconrel.2026.114920 · Cited by 13 · see citing works

Role of mechanosensitive channel Piezo1 protein in intestinal inflammation regulation: A potential target

Jiang, Q., Li, Z., Dang, D., Wei, J., & Wu, H. M. (2024) · The FASEB Journal · doi:10.1096/fj.202401323r · Cited by 13 · see citing works

Isolation and characterization of porcine macrophages and their inflammatory and fusion responses in different stiffness environments

Meli, V. S., Donahue, R. P., Link, J. M., Hu, J. C. Y., Athanasiou, K. A., & Liu, W. F. (2021) · Biomaterials Science · doi:10.1039/d1bm00746g · Cited by 13 · see citing works

A myogenic niche with a proper mechanical stress environment improves abdominal wall muscle repair by modulating immunity and preventing fibrosis

Wang, S., Yan, H., Fang, B., Gu, C., Guo, J., Qiu, P., Song, N., Xu, W., Zhang, J., Lin, X., et al. (2022) · Biomaterials · doi:10.1016/j.biomaterials.2022.121519 · Cited by 12 · see citing works

Data driven and biophysical insights into the regulation of trafficking vesicles by extracellular matrix stiffness

Parihar, K., Nukpezah, J., Iwamoto, D. V., Janmey, P., & Radhakrishnan, R. (2022) · iScience · doi:10.1016/j.isci.2022.104721 · Cited by 11 · see citing works

Extracellular matrix architecture promotes immunosuppressive microenvironments in pancreatic cancer

Callaway, M. K., Noonan, B. J., Schwertfeger, K. L., & Provenzano, P. P. (2025) · Matrix Biology · doi:10.1016/j.matbio.2025.09.004 · Cited by 11 · see citing works

Lung dECM matrikine-based hydrogel reverses bleomycin-induced pulmonary fibrosis by suppressing M2 macrophage polarization

Zhu, X., Yang, Y., Mao, S., Liu, Q., Li, Y., Yang, Y., Gao, M., Bao, J., Li, W., & Li, Y. (2024) · Biofabrication · doi:10.1088/1758-5090/ada092 · Cited by 11 · see citing works

Tension-induced organelle stress: an emerging target in fibrosis

Kai, F., Leidal, A. M., & Weaver, V. M. (2025) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2024.12.006 · Cited by 11 · see citing works

Coupled mechanical mapping and interference contrast microscopy reveal viscoelastic and adhesion hallmarks of monocyte differentiation into macrophages

Eroles, M., Alonso, J. L., Ortega, A., Boudier, T., Gharzeddine, K., Lafont, F., Franz, C. M., Millet, A., Valotteau, C., & Rico, F. (2023) · Nanoscale · doi:10.1039/d3nr00757j · Cited by 11 · see citing works

Stiffness- and Bioactive Factor-Mediated Protection of Self-Assembled Cartilage against Macrophage Challenge in a Novel Co-Culture System

Donahue, R. P., Link, J. M., Meli, V. S., Hu, J. C. Y., Liu, W. F., & Athanasiou, K. A. (2022) · Cartilage · doi:10.1177/19476035221081466 · Cited by 10 · see citing works

Ultraviolet-induced Glycyrrhiza polysaccharide hydrogels with different mechanical strength for wound management

Wang, Z., Luo, M., Ni, L., Li, Y., Liu, D., Zhu, H., Xia, B., Liu, Y., Liu, Q., & Yang, B. (2025) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2025.124712 · Cited by 9 · see citing works

Inflammasomes as regulators of mechano-immunity

Bezbradica, J. S., & Bryant, C. E. (2023) · EMBO Reports · doi:10.1038/s44319-023-00008-2 · Cited by 9 · see citing works

Characterization of Macrophage and Cytokine Interactions with Biomaterials Used in Negative-Pressure Wound Therapy

Veerasubramanian, P. K., Joe, V., Liu, W. F., & Downing, T. L. (2021) · Bioengineering · doi:10.3390/bioengineering9010002 · Cited by 9 · see citing works

A study of macrophage mechanical properties and functional modulation based on the Young's modulus of PLGA-PEG fibers

Zhang, B., Galluzzi, M., Zhou, G., & Yu, H. (2022) · Biomaterials Science · doi:10.1039/d2bm01351g · Cited by 9 · see citing works

Biophysical and Epigenetic Regulation of Cancer Stemness, Invasiveness, and Immune Action

Veerasubramanian, P. K., Trinh, A., Akhtar, N., Liu, W. F., & Downing, T. L. (2020) · Current Tissue Microenvironment Reports · doi:10.1007/s43152-020-00021-w · Cited by 8 · see citing works

Berberine alleviates DSS-induced colitis by modulating macrophage phenotype via PPAR-γ/ mTOR/HIF-1α signaling pathway

He, L., Zhong, Z., Liu, F., & Wen, S. (2026) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2026.121350 · Cited by 7 · see citing works

Transcription factor c‐Maf drives macrophages to promote hypertrophic scar formation

Liu, Y., Song, Y., Wang, T., Cui, Z., Wu, J., Shi, Y., Yu, Z., & Song, B. (2023) · Journal of Cosmetic Dermatology · doi:10.1111/jocd.15952 · Cited by 7 · see citing works

The role of macrophages in rosacea: implications for targeted therapies

Liu, Y., Zhou, Y., Chu, C., & Jiang, X. L. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1211953 · Cited by 6 · see citing works

The transcription factor RBPJ is required for inflammatory macrophage activation in thoracic aortic dissection by mediating mechanotransduction-induced glycolysis

Yin, Z., Wen, T., Cao, X., Lv, Z.-X., Su, Y., Liang, L., Zhang, P., Yang, Z., Han, H., Yan, X., et al. (2025) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-025-05908-1 · Cited by 6 · see citing works

Chronic compression induces transcriptional, metabolic, and functional state changes in macrophages that recapitulate tumor-associated phenotypes

Burchett, A. A., Chen, H., Najera, J., Howard, S. S., & Datta, M. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1626024 · Cited by 6 · see citing works

Osteoimmunology uncovered: How macrophages and biomaterials revolutionize bone healing

Wang, Y., Wang, B., Liu, D., Xu, L., Hu, X., Liu, X., Zheng, H., Wang, Z., Cheng, M., & Yan, W. (2025) · Materials Today Bio · doi:10.1016/j.mtbio.2025.102647 · Cited by 8 · see citing works

Increased H3K9me3 and F-Actin Reorganization in the Rapid Adaptive Response to Hypergravity in Human T Lymphocytes

Wernlé, K., Thiel, C. S., & Ullrich, O. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242417232 · Cited by 6 · see citing works

Dichroa febrifuga Lour.: A review of its botany, traditional use, phytochemistry, pharmacological activities, toxicology, and progress in reducing toxicity

Wang, M., Xu, X., Bai, Q.-X., Wu, L., Yang, X., Yang, D.-Q., & Kuang, H. (2024) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2024.118093 · Cited by 6 · see citing works

A crosstalk between adhesion and phagocytosis integrates macrophage functions into their microenvironment

Depierre, M., Mularski, A., Ruppel, A., Clainche, C. L., Balland, M., & Niedergang, F. (2025) · iScience · doi:10.1016/j.isci.2025.112067 · Cited by 6 · see citing works

Potential of 2D Materials: Novel Insights and Applications in Colorectal Cancer Research

Younis, M., Digra, S. K., Gupta, A., Anand, A. V., & Kumar, P. (2024) · Engineering materials · doi:10.1007/978-981-99-8010-9_13 · Cited by 5 · see citing works

Osteoimmunomodulatory potential of 3D printed submicron patterns assessed in a direct co-culture model

Nouri‐Goushki, M., Eijkel, B. I. M., Minneboo, M., Fratila-Apachitei, L. E., & ZADPOOR, A. A. (2022) · Biomaterials Advances · doi:10.1016/j.bioadv.2022.212993 · Cited by 5 · see citing works

Matrix design for optimal pancreatic β cells transplantation

Rajkumari, N., Shalayel, I., Tubbs, E., Perrier, Q., Chabert, C., Lablanche, S., Benhamou, P., Arnol, C., Gredy, L., Divoux, T., et al. (2024) · Biomaterials Advances · doi:10.1016/j.bioadv.2024.213980 · Cited by 4 · see citing works

Modulation of macrophages by biophysical cues in health and beyond

Wilson, H. M. (2023) · Discovery Immunology · doi:10.1093/discim/kyad013 · Cited by 26 · see citing works

Biomaterial-based physical regulation of macrophage behaviour

Zhou, H., Xue, Y., Dong, L., & Wang, C. (2021) · Journal of Materials Chemistry B · doi:10.1039/d1tb00107h · Cited by 47 · see citing works

Immunity in motion: The role of mechanics in macrophage biology

Khanmohammadi, M., Mirzaalikhan, Y., & Baratchi, S. (2025) · Cell chemical biology · doi:10.1016/j.chembiol.2025.11.004 · Cited by 28 · see citing works

Mechanosensing in macrophages and dendritic cells in steady-state and disease

Lee, M., Du, H., Winer, D. A., Clemente-Casares, X., & Tsai, S. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.1044729 · Cited by 99 · see citing works

The Molecular Mechanism of Macrophages in Response to Mechanical Stress

Su, Y., & Yin, X. (2024) · Annals of Biomedical Engineering · doi:10.1007/s10439-024-03616-8 · Cited by 20 · see citing works