Kopan, Raphael

A presenilin-1-dependent γ-secretase-like protease mediates release of Notch intracellular domain

De Strooper, B., Annaert, W., Cupers, P., Saftig, P., Craessaerts, K., Mumm, J. S., Schroeter, E. H., Schrijvers, V., Wolfe, M. S., Ray, W. J., et al. (1999) · Nature

Alzheimer's disease research and treatmentsDevelopmental Biology and Gene Regulation

Cited by 2,100

AHR drives the development of gut ILC22 cells and postnatal lymphoid tissues via pathways dependent on and independent of Notch

Lee, J. S., Cella, M., McDonald, K. G., Garlanda, C., Kennedy, G. D., Nukaya, M., Mantovani, A., Kopan, R., Bradfield, C. A., Newberry, R. D., et al. (2012) · Nature Immunology

IL-33, ST2, and ILC PathwaysT-cell and B-cell Immunology

Cited by 777

Notch signaling maintains bone marrow mesenchymal progenitors by suppressing osteoblast differentiation

Hilton, M. J., Tu, X., Wu, X., Bai, S., Zhao, H., Kobayashi, T., Kronenberg, H. M., Teitelbaum, S. L., Ross, F. P., Kopan, R., et al. (2008) · Nature Medicine

Bone Metabolism and DiseasesDevelopmental Biology and Gene Regulation

Cited by 604

Notch1 loss of heterozygosity causes vascular tumors and lethal hemorrhage in mice

Liu, Z., Turkoz, A., Jackson, E. N., Corbo, J. C., Engelbach, J. A., Garbow, J. R., Piwnica-Worms, D. R., & Kopan, R. (2011) · Journal of Clinical Investigation

Developmental Biology and Gene RegulationAngiogenesis and VEGF in Cancer

Cited by 119

rtTA toxicity limits the usefulness of the SP-C-rtTA transgenic mouse

Morimoto, M., & Kopan, R. (2009) · Developmental Biology

Neonatal Respiratory Health ResearchAnimal Genetics and Reproduction

Cited by 62

Reduced nephron endowment in the common Six2-TGC tg mouse line is due to Six3 misexpression by aberrant enhancer-promoter interactions in the transgene

Perl, A. J., Liu, H., Hass, M., Adhikari, N., Chaturvedi, P., Hu, Y.-C., Jiang, R., Liu, Y., & Kopan, R. (2023) · Journal of the American Society of Nephrology

Renal and related cancersDevelopmental Biology and Gene Regulation

Cited by 10

Reduced Nephron Endowment in Six2-TGC tg Mice Is Due to Six3 Misexpression by Aberrant Enhancer–Promoter Interactions in the Transgene

Perl, A. J., Liu, H., Hass, M., Adhikari, N., Chaturvedi, P., Hu, Y.-C., Jiang, R., Liu, Y., & Kopan, R. (2024) · Journal of the American Society of Nephrology

Renal and related cancersDevelopmental Biology and Gene Regulation

Cited by 10