Notch signaling maintains bone marrow mesenchymal progenitors by suppressing osteoblast differentiation

Notch Signaling: Cell Fate Control and Signal Integration in Development

Artavanis-Tsakonas, S., Rand, M. D., & Lake, R. J. (1999) · Science · doi:10.1126/science.284.5415.770 · Cited by 5,909 · see citing works

Generalized lacZ expression with the ROSA26 Cre reporter strain

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Bone Marrow Stromal Stem Cells: Nature, Biology, and Potential Applications

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Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain

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Reaching a Genetic and Molecular Understanding of Skeletal Development

Karsenty, G., & Wagner, E. F. (2002) · Developmental Cell · doi:10.1016/s1534-5807(02)00157-0 · Cited by 1,594 · see citing works

Mutations in NOTCH1 cause aortic valve disease

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HES and HERP families: Multiple effectors of the notch signaling pathway

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Stromal Stem Cells: Marrow‐Derived Osteogenic Precursors

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Notch signaling is essential for vascular morphogenesis in micePreprint

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Expression of Cre recombinase in the developing mouse limb bud driven by a Prxl enhancer

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Notch1 is required for the coordinate segmentation of somites

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Skeletal and CNS Defects in Presenilin-1-Deficient Mice

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Integration of Notch and Wnt signaling in hematopoietic stem cell maintenance

Duncan, A. W., Rattis, F. M., DiMascio, L. N., Congdon, K. L., Pazianos, G., Zhao, C., Yoon, K., Cook, J. M., Willert, K., Gaiano, N., et al. (2005) · Nature Immunology · doi:10.1038/ni1164 · Cited by 770 · see citing works

Embryonic Lethality and Vascular Defects in Mice Lacking the Notch Ligand Jagged1

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Notch1 is essential for postimplantation development in mice.Preprint

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Presenilin 1 is required for Notch 1 and Dll1 expression in the paraxial mesoderm

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Maintenance of somite borders in mice requires the Delta homologue Dll1

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Haploinsufficiency of delta-like 4 ligand results in embryonic lethality due to major defects in arterial and vascular development

Gale, N. W., Dominguez, M. G., Noguera, I., Pan, L., Hughes, V., Valenzuela, D. M., Murphy, A. J., Adams, N. C., Lin, H. C., Holash, J., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407290101 · Cited by 600 · see citing works

Dosage‐sensitive requirement for mouse Dll4 in artery development

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Notch3 is required for arterial identity and maturation of vascular smooth muscle cellsPreprint

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Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency

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Mice lacking both presenilin genes exhibitearlyembryonic patterningdefectsPreprint

Donoviel, D. B., Hadjantonakis, A., Ikeda, M., Zheng, H., George‐Hyslop, P. S., & Bernstein, A. (1999) · Genes & Development · doi:10.1101/gad.13.21.2801 · Cited by 457 · see citing works

Defects in limb, craniofacial, and thymic development in Jagged2 mutant micePreprint

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Concise Review: Notch Signaling in Stem Cell Systems

Chiba, S. (2006) · Stem Cells · doi:10.1634/stemcells.2005-0661 · Cited by 400 · see citing works

γ-Secretase Functions through Notch Signaling to Maintain Skin Appendages but Is Not Required for Their Patterning or Initial Morphogenesis

Pan, Y., Lin, M., Tian, X., Cheng, H., Gridley, T., Shen, J., & Kopan, R. (2004) · Developmental Cell · doi:10.1016/j.devcel.2004.09.014 · Cited by 326 · see citing works

Embryonic lethality in mice homozygous for a processing-deficient allele of Notch1

Huppert, S. S., Le, A., Schroeter, E. H., Mumm, J. S., Saxena, M. T., Milner, L. A., & Kopan, R. (2000) · Nature · doi:10.1038/35016111 · Cited by 323 · see citing works

Noncanonical Wnt Signaling through G Protein-Linked PKCδ Activation Promotes Bone Formation

Tu, X., Joeng, K. S., Nakayama, K., Nakayama, K., Rajagopal, J., Carroll, T. J., McMahon, A. P., & Long, F. (2007) · Developmental Cell · doi:10.1016/j.devcel.2006.11.003 · Cited by 314 · see citing works

Mutation in ankyrin repeats of the mouse Notch2 gene induces early embryonic lethality

Hamada, Y., Kadokawa, Y., Okabe, M., Ikawa, M., Coleman, J. R., & Tsujimoto, Y. (1999) · Development · doi:10.1242/dev.126.15.3415 · Cited by 283 · see citing works

Osteoblast-derived PTHrP is a potent endogenous bone anabolic agent that modifies the therapeutic efficacy of administered PTH 1-34

Miao, D. (2005) · Journal of Clinical Investigation · doi:10.1172/jci24918 · Cited by 277 · see citing works

APP Processing and Synaptic Plasticity in Presenilin-1 Conditional Knockout Mice

Yu, H., Saura, C. A., Choi, S., Sun, L. D., Yang, X., Handler, M., Kawarabayashi, T., Younkin, L. H., Fedeles, B. I., Wilson, M. A., et al. (2001) · Neuron · doi:10.1016/s0896-6273(01)00417-2 · Cited by 255 · see citing works

NOTCH1 Regulates Osteoclastogenesis Directly in Osteoclast Precursors and Indirectly via Osteoblast Lineage Cells

Bai, S., Kopan, R., Zou, W., Hilton, M. J., Ong, C., Long, F., Ross, F. P., & Teitelbaum, S. L. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m707000200 · Cited by 236 · see citing works

Coordinated Activation of Notch, Wnt, and Transforming Growth Factor-β Signaling Pathways in Bone Morphogenic Protein 2-induced Osteogenesis

Zamurovic, N., Cappellen, D., Rohner, D., & Šuša, M. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m403813200 · Cited by 234 · see citing works

Notch 1 Overexpression Inhibits Osteoblastogenesis by Suppressing Wnt/β-Catenin but Not Bone Morphogenetic Protein Signaling

Deregowski, V., Gazzerro, E., Priest, L., Rydziel, S., & CANALIS, E. M. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m508370200 · Cited by 231 · see citing works

Axial skeletal defects caused by mutation in the spondylocostal dysplasia/pudgy geneDll3are associated with disruption of the segmentation clock within the presomitic mesoderm

Dunwoodie, S. L., Clements, M., Sparrow, D. B., Sa, X., Conlon, R. A., & Beddington, R. S. P. (2002) · Development · doi:10.1242/dev.129.7.1795 · Cited by 220 · see citing works

Target Selectivity of Vertebrate Notch Proteins

Ong, C., Cheng, H., Chang, L., Ohtsuka, T., Kageyama, R., Stormo, G. D., & Kopan, R. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m506108200 · Cited by 218 · see citing works

A common enzyme connects Notch signaling and Alzheimer's diseasePreprint

Kopan, R., & Goate, A. (2000) · Genes & Development · doi:10.1101/gad.836900 · Cited by 217 · see citing works

Critical Regulation of Bone Morphogenetic Protein-induced Osteoblastic Differentiation by Delta1/Jagged1-activated Notch1 Signaling

Nobta, M., Tsukazaki, T., Shibata, Y., Chang, X., Moriishi, T., Sakano, S., Shindo, H., & Yamaguchi, A. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m412891200 · Cited by 211 · see citing works

Stimulation of Osteoblastic Cell Differentiation by Notch

Tezuka, K.-I., Yasuda, M., Watanabe, N., Morimura, N., Kuroda, K., Miyatani, S., & Hozumi, N. (2002) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2002.17.2.231 · Cited by 208 · see citing works

The shortest path from the surface to the nucleus: RBP‐Jκ/Su(H) transcription factor

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Notch 1 Impairs Osteoblastic Cell Differentiation

Sciaudone, M. P., Gazzerro, E., Priest, L., Delany, A. M., & CANALIS, E. M. (2003) · Endocrinology · doi:10.1210/en.2003-0463 · Cited by 192 · see citing works

Ihh controls cartilage development by antagonizing Gli3, but requires additional effectors to regulate osteoblast and vascular development

Hilton, M. J., Tu, X., Cook, J., Hu, H., & Long, F. (2005) · Development · doi:10.1242/dev.02025 · Cited by 186 · see citing works

Mapping the consequence of Notch1 proteolysis in vivo with NIP-CRE

Vooijs, M., Ong, C., Hadland, B., Huppert, S. S., Liu, Z., Korving, J., van den Born, M., Stappenbeck, T. S., Wu, Y., Clevers, H. C., et al. (2007) · Development · doi:10.1242/dev.02733 · Cited by 146 · see citing works

The interplay of osteogenesis and hematopoiesis

Kuznetsov, S. A., Riminucci, M., Ziran, N. M., Tsutsui, T. W., Corsi, A., Calvi, L. M., Kronenberg, H. M., Schipani, E., Robey, P. G., & Bianco, P. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200408079 · Cited by 112 · see citing works

Generation of new Notch2 mutant alleles

McCright, B., Lozier, J., & Gridley, T. (2006) · genesis · doi:10.1002/gene.20181 · Cited by 93 · see citing works

Erratum: Embryonic lethality in mice homozygous for a processing-deficient allele of Notch1

Huppert, S. S., Le, A., Schroeter, E. H., Mumm, J. S., Saxena, M. T., Milner, L. A., & Kopan, R. (2000) · Nature · doi:10.1038/35046136 · Cited by 74 · see citing works

Osteogenic differentiation of the mesenchymal progenitor cells, Kusa is suppressed by Notch signaling

Shindo, K., Kawashima, N., Sakamoto, K., Yamaguchi, A., Umezawa, A., Takagi, M., Katsube, K., & Suda, H. (2003) · Experimental Cell Research · doi:10.1016/s0014-4827(03)00349-5 · Cited by 72 · see citing works

Notch1 and 2 cooperate in limb ectoderm to receive an early Jagged2 signal regulating interdigital apoptosis

Pan, Y., Liu, Z., Shen, J., & Kopan, R. (2005) · Developmental Biology · doi:10.1016/j.ydbio.2005.08.037 · Cited by 67 · see citing works

Notch pathway is dispensable for adipocyte specification

Nichols, A. M., Pan, Y., Herreman, A., Hadland, B., Strooper, B. D., Kopan, R., & Huppert, S. S. (2004) · genesis · doi:10.1002/gene.20061 · Cited by 52 · see citing works

Mechanisms of bone development and repair

Salhotra, A., Shah, H. N., Lévi, B., & Longaker, M. T. (2020) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-00279-w · Cited by 1,243 · see citing works

Building strong bones: molecular regulation of the osteoblast lineage

Long, F. (2011) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3254 · Cited by 1,149 · see citing works

Notch signaling pathway: architecture, disease, and therapeutics

Zhou, B., Lin, W., Long, Y., Yang, Y., Zhang, H., Wu, K., & Chu, Q. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-00934-y · Cited by 1,145 · see citing works

Endothelial Notch activity promotes angiogenesis and osteogenesis in bone

Ramasamy, S. K., Kusumbe, A. P., Wang, L., & Adams, R. H. (2014) · Nature · doi:10.1038/nature13146 · Cited by 1,071 · see citing works

Bone biomaterials and interactions with stem cells

Gao, C., Peng, S., Feng, P., & Shuai, C. (2017) · Bone Research · doi:10.1038/boneres.2017.59 · Cited by 727 · see citing works

Genetic Control of Bone Formation

Karsenty, G., Kronenberg, H. M., & Settembre, C. (2009) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.042308.113308 · Cited by 667 · see citing works

Development of the Endochondral SkeletonPreprint

Long, F., & Ornitz, D. M. (2013) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a008334 · Cited by 665 · see citing works

Osteoblast Differentiation at a Glance

Rutkovskiy, A., Stensløkken, K., & Vaage, J. (2016) · Medical science monitor basic research/Medical science monitor. Basic research · doi:10.12659/msmbr.901142 · Cited by 620 · see citing works

Tumor-Derived Jagged1 Promotes Osteolytic Bone Metastasis of Breast Cancer by Engaging Notch Signaling in Bone Cells

Sethi, N. S., Dai, X., Winter, C. G., & Kang, Y. (2011) · Cancer Cell · doi:10.1016/j.ccr.2010.12.022 · Cited by 573 · see citing works

The roles of signaling pathways in bone repair and regeneration

Majidinia, M., Sadeghpour, A., & Yousefi, B. (2017) · Journal of Cellular Physiology · doi:10.1002/jcp.26042 · Cited by 515 · see citing works

Integration of BMP, Wnt, and notch signaling pathways in osteoblast differentiation

Lin, G. L., & Hankenson, K. D. (2011) · Journal of Cellular Biochemistry · doi:10.1002/jcb.23287 · Cited by 508 · see citing works

Bone physiological microenvironment and healing mechanism: Basis for future bone-tissue engineering scaffolds

Zhu, G., Zhang, T., Chen, M., Yao, K., Huang, X., Zhang, B., Li, Y., Liu, J., Wang, Y., & Zhao, Z. (2021) · Bioactive Materials · doi:10.1016/j.bioactmat.2021.03.043 · Cited by 501 · see citing works

Germline and somatic genetics of osteosarcoma — connecting aetiology, biology and therapy

Gianferante, D. M., Mirabello, L. J., & Savage, S. A. (2017) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2017.16 · Cited by 470 · see citing works

Runx2, an inducer of osteoblast and chondrocyte differentiation

Komori, T. (2018) · Histochemistry and Cell Biology · doi:10.1007/s00418-018-1640-6 · Cited by 468 · see citing works

Blood vessel formation and function in bone

Sivaraj, K. K., & Adams, R. H. (2016) · Development · doi:10.1242/dev.136861 · Cited by 439 · see citing works

Silk fibroin/hydroxyapatite composites for bone tissue engineering

Farokhi, M., Mottaghitalab, F., Samani, S., Shokrgozar, M. A., Kundu, S. C., Reis, R. L., Fatahi, Y., & Kaplan, D. L. (2017) · Biotechnology Advances · doi:10.1016/j.biotechadv.2017.10.001 · Cited by 435 · see citing works

Blood flow controls bone vascular function and osteogenesis

Ramasamy, S. K., Kusumbe, A. P., Schiller, M., Zeuschner, D., Bixel, M. G., Milia, C., Gamrekelashvili, J., Limbourg, A., Medvinsky, A., Santoro, M. M., et al. (2016) · Nature Communications · doi:10.1038/ncomms13601 · Cited by 433 · see citing works

The RUNX family: developmental regulators in cancer

Ito, Y., Bae, S.-C., & Chuang, L. S. H. (2015) · Nature Reviews Cancer · doi:10.1038/nrc3877 · Cited by 399 · see citing works

Notch Signaling and the Skeleton.

Zanotti, S., & Canalis, E. (2016) · Endocrine reviews · doi:10.1210/er.2016-1002 · Cited by 283 · see citing works

Canonical Notch Signaling Is Dispensable for the Maintenance of Adult Hematopoietic Stem Cells

Maillard, I., Koch, U., Dumortier, A., Shestova, O., Xu, L., Sai, H., Pross, S. E., Aster, J. C., Bhandoola, A., Radtke, F., et al. (2008) · Cell Stem Cell · doi:10.1016/j.stem.2008.02.011 · Cited by 317 · see citing works

Notch Signaling in the Regulation of Stem Cell Self-Renewal and Differentiation

Liu, J., Sato, C., Cerletti, M., & Wagers, A. J. (2010) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/s0070-2153(10)92012-7 · Cited by 309 · see citing works

The material and biological characteristics of osteoinductive calcium phosphate ceramics

Tang, Z., Li, X., Tan, Y., Fan, H., & Zhang, X. (2017) · Regenerative Biomaterials · doi:10.1093/rb/rbx024 · Cited by 301 · see citing works

Osteocytes mediate the anabolic actions of canonical Wnt/β-catenin signaling in bone

Tu, X., Delgado‐Calle, J., Condon, K. W., Maycas, M., Zhang, H., Carlesso, N., Taketo, M. M., Burr, D. B., Plotkin, L. I., & Bellido, T. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1409857112 · Cited by 278 · see citing works

Uncovering the periosteum for skeletal regeneration: The stem cell that lies beneath

Roberts, S. J., van Gastel, N., Carmeliet, G., & Luyten, F. P. (2014) · Bone · doi:10.1016/j.bone.2014.08.007 · Cited by 263 · see citing works

Cell autonomous requirement of connexin 43 for osteocyte survival: Consequences for endocortical resorption and periosteal bone formation

Bivi, N., Condon, K. W., Allen, M. R., Farlow, N., Passeri, G., Brun, L. R., Rhee, Y., Bellido, T., & Plotkin, L. I. (2012) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.548 · Cited by 261 · see citing works

Identification of differentially expressed genes between osteoblasts and osteocytes

Paić, F., Igwe, J. C., Nori, R., Kronenberg, M. S., Franceschetti, T., Harrington, P., Kuo, L., Shin, D., Rowe, D. W., Harris, S. E., et al. (2009) · Bone · doi:10.1016/j.bone.2009.06.010 · Cited by 261 · see citing works

The endothelium–bone axis in development, homeostasis and bone and joint disease

Tuckermann, J., & Adams, R. H. (2021) · Nature Reviews Rheumatology · doi:10.1038/s41584-021-00682-3 · Cited by 258 · see citing works

The Regulation of Valvular and Vascular Sclerosis by Osteogenic Morphogens

Boström, K. I., Rajamannan, N. M., & Towler, D. A. (2011) · Circulation Research · doi:10.1161/circresaha.110.234278 · Cited by 256 · see citing works

Mitogen-Activated Protein Kinase Pathways in Osteoblasts

Greenblatt, M. B., Shim, J., & Glimcher, L. H. (2013) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-101512-122347 · Cited by 252 · see citing works

Endothelial Jagged-1 Is Necessary for Homeostatic and Regenerative Hematopoiesis

Poulos, M. G., Guo, P., Kofler, N. M., Pinho, S., Gutkin, M. C., Tikhonova, A. N., Aifantis, I., Frenette, P. S., Kitajewski, J., Rafii, S., et al. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.07.048 · Cited by 249 · see citing works

Role of Notch signaling in regulating innate immunity and inflammation in health and disease

Shang, Y., Smith, S. M., & Hu, X. (2016) · Protein & Cell · doi:10.1007/s13238-016-0250-0 · Cited by 248 · see citing works

MSC Transplantation Improves Osteopenia via Epigenetic Regulation of Notch Signaling in Lupus

Liu, S., Liu, D., Chen, C., Hamamura, K., Moshaverinia, A., Yang, R., Liu, Y., Jin, Y. J., & Shi, S. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.08.018 · Cited by 247 · see citing works

Molecular genetics of osteosarcoma

Rickel, K., Fang, F., & Tao, J. (2016) · Bone · doi:10.1016/j.bone.2016.10.017 · Cited by 244 · see citing works

miRNA-34c regulates Notch signaling during bone development

Bae, Y., Yang, T., Zeng, H., Campeau, P. M., Chen, Y., Bertin, T., Dawson, B., Munivez, E. M., Tao, J., & Lee, B. (2012) · Human Molecular Genetics · doi:10.1093/hmg/dds129 · Cited by 237 · see citing works

miR-34s inhibit osteoblast proliferation and differentiation in the mouse by targeting SATB2

Wei, J., Shi, Y., Zheng, L., Zhou, B., Inose, H., Wang, J., Guo, X.-D. E., Grosschedl, R., & Karsenty, G. (2012) · The Journal of Cell Biology · doi:10.1083/jcb.201201057 · Cited by 219 · see citing works

Potential mechanisms underlying the Runx2 induced osteogenesis of bone marrow mesenchymal stem cells.

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Age-related alterations in mesenchymal stem cells related to shift in differentiation from osteogenic to adipogenic potential: Implication to age-associated bone diseases and defects

Kim, M. J., Kim, C., Choi, Y. S., Kim, M., Park, C., & Suh, Y. (2012) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2012.03.014 · Cited by 207 · see citing works

Notch signaling in chondrocytes modulates endochondral ossification and osteoarthritis development

Hosaka, Y., Saito, T., Sugita, S., Hikata, T., Kobayashi, H., Fukai, A., Taniguchi, Y., Hirata, M., Akiyama, H., Chung, U., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1207458110 · Cited by 202 · see citing works

Notch Inhibits Osteoblast Differentiation and Causes Osteopenia

Zanotti, S., Smerdel‐Ramoya, A., Stadmeyer, L., Durant, D., Radtke, F., & CANALIS, E. M. (2008) · Endocrinology · doi:10.1210/en.2008-0140 · Cited by 200 · see citing works

Hes1: a key role in stemness, metastasis and multidrug resistance

Liu, Z.-H., Dai, X., & Du, B. (2015) · Cancer Biology & Therapy · doi:10.1080/15384047.2015.1016662 · Cited by 198 · see citing works

Truncating mutations in the last exon of NOTCH2 cause a rare skeletal disorder with osteoporosis

Isidor, B., Lindenbaum, P., Pichon, O., Bezieau, S., Christian Dina, C., Jacquemont, S., Martin‐Coignard, D., Thauvin‐Robinet, C., Merrer, M. F. L., Mandel, J., et al. (2011) · Nature Genetics · doi:10.1038/ng.778 · Cited by 196 · see citing works

Molecular and Cellular Aspects of Calcific Aortic Valve Disease

Towler, D. A. (2013) · Circulation Research · doi:10.1161/circresaha.113.300155 · Cited by 193 · see citing works

Notch and disease: A growing field

Louvi, A., & Artavanis‐Tsakonas, S. (2012) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2012.02.005 · Cited by 192 · see citing works

Wnt pathway, an essential role in bone regeneration

Chen, Y., & Alman, B. A. (2009) · Journal of Cellular Biochemistry · doi:10.1002/jcb.22020 · Cited by 188 · see citing works

Exosome: A Novel Approach to Stimulate Bone Regeneration through Regulation of Osteogenesis and Angiogenesis

Qin, Y., Sun, R., Wu, C., Wang, L. Y., & Zhang, C. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17050712 · Cited by 185 · see citing works

TNF-induced osteoclastogenesis and inflammatory bone resorption are inhibited by transcription factor RBP-J

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Natural and synthetic polymers/bioceramics/bioactive compounds-mediated cell signalling in bone tissue engineering

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Analysis of αSMA-Labeled Progenitor Cell Commitment Identifies Notch Signaling as an Important Pathway in Fracture Healing

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Genetic and Transcriptional Control of Bone Formation

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Notch Activation as a Driver of Osteogenic Sarcoma

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Modulation of Notch-1 Signaling Alleviates Vascular Endothelial Growth Factor–Mediated Diabetic Nephropathy

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Inhibitory Role of Notch1 in Calcific Aortic Valve Disease

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Bone Marrow–Derived Mesenchymal Stem Cells Obtained During Arthroscopic Rotator Cuff Repair Surgery Show Potential for Tendon Cell Differentiation After Treatment With Insulin

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Notch signaling and the bone marrow hematopoietic stem cell niche

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Notch Signaling in Osteocytes Differentially Regulates Cancellous and Cortical Bone Remodeling

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A Dual Role for NOTCH Signaling in Joint Cartilage Maintenance and Osteoarthritis

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Notch signaling enhances osteogenic differentiation while inhibiting adipogenesis in primary human bone marrow stromal cells

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The role of microRNAs in bone remodeling

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Vegfa regulates perichondrial vascularity and osteoblast differentiation in bone development

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Cartilage-specific RBPjκ-dependent and -independent Notch signals regulate cartilage and bone development

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Osteogenic differentiation of the mesenchymal progenitor cells, Kusa is suppressed by Notch signaling

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Physiological Notch Signaling Maintains Bone Homeostasis via RBPjk and Hey Upstream of NFATc1

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