Sebastián, David

Mitofusin 2 (Mfn2) links mitochondrial and endoplasmic reticulum function with insulin signaling and is essential for normal glucose homeostasis

Sebastián, D., Hernández-Alvarez, M. I., Segalés, J., Sorianello, E., Muñoz, J. P., Sala, D., Waget, A., Liesa, M., Paz, J. C., Gopalacharyulu, P., et al. (2012) · Proceedings of the National Academy of Sciences

Mitochondrial Function and PathologyMetabolism, Diabetes, and Cancer

Cited by 673

Mitofusin 2 in POMC neurons connects ER stress with leptin resistance and energy imbalance

Schneeberger, M., Dietrich, M. O., Sebastián, D., Imbernón, M., Castaño, C., Garcia, A., Esteban, Y., Gonzalez-Franquesa, A., Rodríguez, I. C., Bortolozzi, A., et al. (2013) · Cell

Regulation of Appetite and ObesityMitochondrial Function and Pathology

Cited by 519

Mfn2 modulates the UPR and mitochondrial function via repression of PERK

Muñoz, J. P., Ivanova, S., Sánchez‐Wandelmer, J., Martínez‐Cristóbal, P., Noguera, E., Sancho, A., Díaz‐Ramos, A., Hernández‐Alvarez, M. I., Sebastián, D., Mauvezin, C., et al. (2013) · The EMBO Journal

Endoplasmic Reticulum Stress and DiseaseMitochondrial Function and Pathology

Cited by 451

Mfn2 deficiency links age‐related sarcopenia and impaired autophagy to activation of an adaptive mitophagy pathway

Sebastián, D., Sorianello, E., Segalés, J., Irazoki, A., Ruiz‐Bonilla, V., Sala, D., Planet, E., Berenguer‐Llergo, A., Muñoz, J. P., Sánchez‐Feutrie, M., et al. (2016) · The EMBO Journal

Mitochondrial Function and PathologyAutophagy in Disease and Therapy

Cited by 396

Mitochondrial DNA and TLR9 drive muscle inflammation upon Opa1 deficiency

Rodríguez‐Nuevo, A., Díaz‐Ramos, A., Noguera, E., Díaz‐Sáez, F., Duran, X., Muñoz, J. P., Romero, M., Plana, N., Sebastián, D., Tezze, C., et al. (2018) · The EMBO Journal

Mitochondrial Function and PathologyMuscle Physiology and Disorders

Cited by 207

CPT I overexpression protects L6E9 muscle cells from fatty acid-induced insulin resistance

Sebastián, D., Herrero, L., Serra, D., Asins, G., & Hegardt, F. G. (2007) · American Journal of Physiology-Endocrinology and Metabolism

Metabolism, Diabetes, and CancerAdipose Tissue and Metabolism

Cited by 89

Circadian- and UPR-dependent control of CPEB4 mediates a translational response to counteract hepatic steatosis under ER stress

Maillo, C., Martín, J., Sebastián, D., Hernández-Alvarez, M., García-Rocha, M., Reina, O., Zorzano, A., Fernandez, M., & Méndez, R. (2017) · Nature Cell Biology

Endoplasmic Reticulum Stress and DiseaseCircadian rhythm and melatonin

Cited by 82

Novel Effect of C75 on Carnitine Palmitoyltransferase I Activity and Palmitate Oxidation

Bentebibel, A., Sebastián, D., Herrero, L., López-Viñas, E., Serra, D., Asins, G., Gómez-Puertas, P., & Hegardt, F. G. (2006) · Biochemistry

Cancer, Lipids, and MetabolismPeroxisome Proliferator-Activated Receptors

Cited by 58

C75 is converted to C75-CoA in the hypothalamus, where it inhibits carnitine palmitoyltransferase 1 and decreases food intake and body weight

Mera, P., Bentebibel, A., López-Viñas, E., Cordente, A. G., Gurunathan, C., Sebastián, D., Vázquez, I., Herrero, L., Ariza, X., Gómez-Puertas, P., et al. (2009) · Biochemical Pharmacology

Regulation of Appetite and ObesityPeroxisome Proliferator-Activated Receptors

Cited by 57

Mitofusin-2 induced by exercise modifies lipid droplet-mitochondria communication, promoting fatty acid oxidation in male mice with NAFLD

Bórquez, J. C., Díaz-Castro, F., La Fuente, F. P.-D., Espinoza, K., Figueroa, A. M., Martínez-Ruíz, I., Hernández, V., López-Soldado, I., Ventura, R., Domingo, J. C., et al. (2024) · Metabolism

Liver Disease Diagnosis and TreatmentMitochondrial Function and Pathology

Cited by 54