Okamoto, Koji

Tumor-derived spheroids: Relevance to cancer stem cells and clinical applications

Ishiguro, T., Ohata, H., Sato, A., Yamawaki, K., Enomoto, T., & Okamoto, K. (2017) · Cancer Science

Cancer Cells and Metastasis3D Printing in Biomedical Research

Cited by 530

Cyclin G is a transcriptional target of the p53 tumor suppressor protein.

Okamoto, K., & Beach, D. (1994) · The EMBO Journal

Cancer-related Molecular PathwaysCell death mechanisms and regulation

Cited by 455

Cyclin G Recruits PP2A to Dephosphorylate Mdm2

Okamoto, K., Li, H., Jensen, M. R., Zhang, T., Taya, Y., Thorgeirsson, S. S., & Prives, C. (2002) · Molecular Cell

Cancer-related Molecular PathwaysPI3K/AKT/mTOR signaling in cancer

Cited by 215

TNIK inhibition abrogates colorectal cancer stemness

Masuda, M., Uno, Y., Ohbayashi, N., Ohata, H., Mimata, A., Kukimoto-Niino, M., Moriyama, H., Kashimoto, S., Inoue, T., Goto, N., et al. (2016) · Nature Communications

Wnt/β-catenin signaling in development and cancerCancer Cells and Metastasis

Cited by 168

DNA Damage-Induced Phosphorylation of MdmX at Serine 367 Activates p53 by Targeting MdmX for Mdm2-Dependent Degradation

Okamoto, K., Kashima, K., Pereg, Y., Ishida, M., Yamazaki, S., Nota, A., Teunisse, A., Migliorini, D., Kitabayashi, I., Marine, J.-C., et al. (2005) · Molecular and Cellular Biology

Cancer-related Molecular Pathways14-3-3 protein interactions

Cited by 129

Differential Roles of ATM- and Chk2-Mediated Phosphorylations of Hdmx in Response to DNA Damage

Pereg, Y., Lam, S., Teunisse, A., Biton, S., Meulmeester, E., Mittelman, L., Buscemi, G., Okamoto, K., Taya, Y., Shiloh, Y., et al. (2006) · Molecular and Cellular Biology

Cancer-related Molecular PathwaysDNA Repair Mechanisms

Cited by 93

Functional role of Mdm2 phosphorylation by ATR in attenuation of p53 nuclear export

Shinozaki, T., Nota, A., Taya, Y., & Okamoto, K. (2003) · Oncogene

Cancer-related Molecular PathwaysDNA Repair Mechanisms

Cited by 93

Mdmx enhances p53 ubiquitination by altering the substrate preference of the Mdm2 ubiquitin ligase

Okamoto, K., Taya, Y., & Nakagama, H. (2009) · FEBS Letters

Cancer-related Molecular PathwaysUbiquitin and proteasome pathways

Cited by 76

Cytoplasmic tethering is involved in synergistic inhibition of p53 by Mdmx and Mdm2

Ohtsubo, C., Shiokawa, D., Kodama, M., Gaiddon, C., Nakagama, H., Jochemsen, A. G., Taya, Y., & Okamoto, K. (2009) · Cancer Science

Cancer-related Molecular PathwaysUbiquitin and proteasome pathways

Cited by 32