Greenamyre, J. Timothy

Early mitochondrial calcium defects in Huntington's disease are a direct effect of polyglutamines

Panov, A. V., Gutekunst, C.-A., Leavitt, B. R., Hayden, M. R., Burke, J. R., Strittmatter, W. J., & Greenamyre, J. T. (2002) · Nature Neuroscience

Genetic Neurodegenerative DiseasesMitochondrial Function and Pathology

Cited by 1,030

α-Synuclein binds to TOM20 and inhibits mitochondrial protein import in Parkinson’s disease

Di Maio, R., Barrett, P. J., Hoffman, E. K., Barrett, C. W., Zharikov, A., Borah, A., Hu, X., McCoy, J., Chu, C. T., Burton, E. A., et al. (2016) · Science Translational Medicine

Parkinson's Disease Mechanisms and TreatmentsMitochondrial Function and Pathology

Cited by 619

Alternative excitotoxic hypotheses

Albin, R. L., & Greenamyre, J. T. (1992) · Neurology

Asthma and respiratory diseasesOccupational exposure and asthma

Cited by 574

Rotenone Model of Parkinson Disease

Panov, A., Dikalov, S., Shalbuyeva, N., Taylor, G., Sherer, T., & Greenamyre, J. T. (2005) · Journal of Biological Chemistry

Parkinson's Disease Mechanisms and TreatmentsMitochondrial Function and Pathology

Cited by 288

Revisiting protein aggregation as pathogenic in sporadic Parkinson and Alzheimer diseases

Espay, A. J., Vizcarra, J. A., Marsili, L., Lang, A. E., Simon, D. K., Merola, A., Josephs, K. A., Fasano, A., Morgante, F., Savica, R., et al. (2019) · Neurology

Parkinson's Disease Mechanisms and TreatmentsAlzheimer's disease research and treatments

Cited by 274

Mitochondrial iron metabolism and its role in neurodegeneration

Horowitz, M. P., & Greenamyre, J. T. (2010) · Journal of Alzheimer s Disease

Iron Metabolism and DisordersNeurological diseases and metabolism

Cited by 195

A novel transferrin/TfR2-mediated mitochondrial iron transport system is disrupted in Parkinson's disease

Mastroberardino, P. G., Hoffman, E. K., Horowitz, M. P., Betarbet, R., Taylor, G., Cheng, D., Na, H. M., Gutekunst, C.-A., Gearing, M., Trojanowski, J. Q., et al. (2009) · Neurobiology of Disease

Parkinson's Disease Mechanisms and TreatmentsIron Metabolism and Disorders

Cited by 195

Species- and tissue-specific relationships between mitochondrial permeability transition and generation of ROS in brain and liver mitochondria of rats and mice

Panov, A., Dikalov, S., Shalbuyeva, N., Hemendinger, R., Greenamyre, J. T., & Rosenfeld, J. (2007) · American Journal of Physiology-Cell Physiology

Mitochondrial Function and PathologyCell death mechanisms and regulation

Cited by 141

Synthetic alpha-synuclein fibrils cause mitochondrial impairment and selective dopamine neurodegeneration in part via iNOS-mediated nitric oxide production

Tapias, V., Hu, X., Luk, K. C., Sanders, L. H., Lee, V. M., & Greenamyre, J. T. (2017) · Cellular and Molecular Life Sciences

Parkinson's Disease Mechanisms and TreatmentsNuclear Receptors and Signaling

Cited by 126

Protection by the NDI1 gene against neurodegeneration in a rotenone rat model of Parkinson's disease

Marella, M., Seo, B. B., Nakamaru-Ogiso, E., Greenamyre, J. T., Matsuno-Yagi, A., & Yagi, T. (2008) · PLoS ONE

Parkinson's Disease Mechanisms and TreatmentsNuclear Receptors and Signaling

Cited by 116