Krystal, Gerald

The 145-kDa protein induced to associate with Shc by multiple cytokines is an inositol tetraphosphate and phosphatidylinositol 3,4,5-triphosphate 5-phosphatase.

Damen, J. E., Liu, L., Rosten, P., Humphries, R. K., Jefferson, A. B., Majerus, P. W., & Krystal, G. (1996) · Proceedings of the National Academy of Sciences

Protein Tyrosine PhosphatasesProtein Kinase Regulation and GTPase Signaling

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Targeted disruption of SHIP leads to hemopoietic perturbations, lung pathology, and a shortened life span

Helgason, C. D., Damen, J. E., Rosten, P., Grewal, R., Sorensen, P., Chappel, S. M., Borowski, A., Jirik, F., Krystal, G., & Humphries, R. K. (1998) · Genes & Development

Hematopoietic Stem Cell TransplantationProtein Tyrosine Phosphatases

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Erythropoietin stimulates the tyrosine phosphorylation of Shc and its association with Grb2 and a 145-Kd tyrosine phosphorylated protein

Damen, J., Liu, L., Cutler, R., & Krystal, G. (1993) · Blood

Erythropoietin and Anemia TreatmentCytokine Signaling Pathways and Interactions

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Negative signaling in B lymphocytes induces tyrosine phosphorylation of the 145-kDa inositol polyphosphate 5-phosphatase, SHIP

Chacko, G. W., Tridandapani, S., Damen, J. E., Liu, L., Krystal, G., & Coggeshall, K. M. (1996) · The Journal of Immunology

T-cell and B-cell ImmunologyProtein Tyrosine Phosphatases

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Shc Interaction with Src Homology 2 Domain Containing Inositol Phosphatase (SHIP) in VivoRequires the Shc-Phosphotyrosine Binding Domain and Two Specific Phosphotyrosines on SHIP

Lamkin, T. D., Walk, S. F., Liu, L., Damen, J. E., Krystal, G., & Ravichandran, K. S. (1997) · Journal of Biological Chemistry

Protein Tyrosine PhosphatasesProtein Kinase Regulation and GTPase Signaling

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Cloning and characterization of human SHIP, the 145-kD inositol 5- phosphatase that associates with SHC after cytokine stimulation

Ware, M., Rosten, P., Damen, J., Liu, L., Humphries, R., & Krystal, G. (1996) · Blood

Protein Tyrosine PhosphatasesCytokine Signaling Pathways and Interactions

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Absence of SHIP-1 Results in Constitutive Phosphorylation of Tank-Binding Kinase 1 and Enhanced TLR3-Dependent IFN-β Production

Gabhann, J. N., Higgs, R., Brennan, K., Thomas, W., Damen, J. E., Ben Larbi, N., Krystal, G., & Jefferies, C. A. (2010) · The Journal of Immunology

interferon and immune responsesImmune Response and Inflammation

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SHIP1 Negatively Regulates Proliferation of Osteoclast Precursors via Akt-Dependent Alterations in D-Type Cyclins and p27

Zhou, P., Kitaura, H., Teitelbaum, S. L., Krystal, G., Ross, F. P., & Takeshita, S. (2006) · The Journal of Immunology

Bone Metabolism and DiseasesRheumatoid Arthritis Research and Therapies

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Effect of age on chronic inflammation and responsiveness to bacterial and viral challenges

Elisia, I., Lam, V., Hofs, E., Li, M. Y., Hay, M., Cho, B., Brooks-Wilson, A., Rosin, M., Bu, L., Jia, W., et al. (2017) · PLOS ONE

Immune Response and InflammationGenetics, Aging, and Longevity in Model Organisms

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Interleukin-10 and Small Molecule SHIP1 Allosteric Regulators Trigger Anti-inflammatory Effects through SHIP1/STAT3 Complexes

Chamberlain, T. C., Cheung, S. T., Yoon, J. S. J., Ming-Lum, A., Gardill, B. R., Shakibakho, S., Dzananovic, E., Ban, F., Samiea, A., Jawanda, K., et al. (2020) · iScience

Cytokine Signaling Pathways and InteractionsProtein Tyrosine Phosphatases

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Apigenin Targets MicroRNA-155, Enhances SHIP-1 Expression, and Augments Anti-Tumor Responses in Pancreatic Cancer

Husain, K., Villalobos-Ayala, K., Laverde, V., Vazquez, O. A., Miller, B., Kazim, S., Blanck, G., Hibbs, M. L., Krystal, G., Elhussin, I., et al. (2022) · Cancers

Flavonoids in Medical ResearchPancreatic and Hepatic Oncology Research

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Development of a novel human triculture model of non-alcoholic fatty liver disease and identification of berberine as ameliorating steatosis, oxidative stress and fibrosis

Rafiei, H., Yeung, M., Kowalski, S., Krystal, G., & Elisia, I. (2023) · Frontiers in Pharmacology

Liver Disease Diagnosis and TreatmentLiver physiology and pathology

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