Erythropoietin stimulates the tyrosine phosphorylation of Shc and its association with Grb2 and a 145-Kd tyrosine phosphorylated protein
Abstract
Although the erythropoietin receptor (EpR) lacks a tyrosine kinase consensus sequence within its proline-rich intracellular domain, addition of its ligand to Ep-responsive cells stimulates the rapid and transient tyrosine phosphorylation of a number of cellular proteins. The characterization of these phosphorylatable substrates, which include 5 major phosphoproteins with molecular masses of approximately 145, 130, 97, 72, and 56 Kd is an essential step in understanding the signal transduction pathways used by Ep. Recently, we and others have shown that the major 72-Kd tyrosine phosphorylated protein is the EpR itself. We now report, using both murine DA-3 and human MO7E cell lines engineered to express high levels of biologically responsive EpRs (and designated DA-ER and MO7-ER, respectively), that the major 56-Kd tyrosine phosphorylated protein is the recently identified SH2-containing protein, p52shc. Interestingly, in Ep-stimulated cells, anti-Shc antibodies coprecipitate the major 145-Kd tyrosine phosphorylated protein in both DA-ER and MO7-ER cells. Tyrosine phosphorylation of both proteins is detectable within 30 seconds of incubation with Ep at 37 degrees C, reaches a maximum between 2 and 5 minutes, and declines by 30 minutes. In addition, tyrosine phosphorylated Shc appears capable of associating with the activated EpR, but this could only be shown in MO7-ER cells. Lastly, as has been shown previously with the tyrosine kinase containing receptors for epidermal growth…
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SHIP1 was originally observed in hematopoietic cells after cytokines and growth factors induced tyrosine phosphorylation of this 145-kDa protein.
“SHIP1 was originally observed in hematopoietic cells after a variety of cytokines and growth factors induced the tyrosine phosphorylation of this 145-kDa protein [98–104].”
From Microglial function, INPP5D/SHIP1 signaling, and NLRP3 inflammasome activation: implications for Alzheimer’s disease (2023) · cites this paper as [101]
Cites
The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling
Lowenstein, E. J., Daly, R. J., Batzer, A., Li, W., Margolis, B. L., Lammers, R., Ullrich, A., Skolnik, E. Y., Bar‐Sagi, D., & Schlessinger, J. (1992) · Cell · doi:10.1016/0092-8674(92)90167-b · Cited by 1,632 · see citing works
A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction
Pelicci, G., Lanfrancone, L., Grignani, F., McGlade, J. C., Cavallo, F., Forni, G., Nicoletti, I., Grignani, F., Pawson, T. J., & Pelicci, P. G. (1992) · Cell · doi:10.1016/0092-8674(92)90536-l · Cited by 1,326 · see citing works
Egan, S. E., Giddings, B. W., Brooks, M. W., Buday, L., Sizeland, A. M., & Weinberg, R. A. (1993) · Nature · doi:10.1038/363045a0 · Cited by 1,200 · see citing works
Buday, L., & Downward, J. (1993) · Cell · doi:10.1016/0092-8674(93)90146-h · Cited by 1,064 · see citing works
The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1
Rozakis-Adcock, M., Fernley, R. T., Wade, J. D., Pawson, T. J., & Bowtell, D. D. L. (1993) · Nature · doi:10.1038/363083a0 · Cited by 1,009 · see citing works
Rozakis-Adcock, M., McGlade, J. C., Mbamalu, G., Pelicci, G., Daly, R. J., Li, W., Batzer, A., Thomas, S. Μ., Brugge, J. S., Pelicci, P. G., et al. (1992) · Nature · doi:10.1038/360689a0 · Cited by 973 · see citing works
Li, N., Batzer, A., Daly, R. J., Yajnik, V., Skolnik, E. Y., Chardin, P., Bar‐Sagi, D., Margolis, B. L., & Schlessinger, J. (1993) · Nature · doi:10.1038/363085a0 · Cited by 938 · see citing works
Simon, M. A., Bowtell, D. D. L., Dodson, G. S., Laverty, T., & Rubin, G. M. (1991) · Cell · doi:10.1016/0092-8674(91)90065-7 · Cited by 860 · see citing works
Human Sos1: a Guanine Nucleotide Exchange Factor for Ras that Binds to GRB2
Chardin, P., Camonis, J., Gale, N. W., Aelst, L. V., Schlessinger, J., Wigler, M. H., & Bar‐Sagi, D. (1993) · Science · doi:10.1126/science.8493579 · Cited by 799 · see citing works
A novel viral oncogene with structural similarity to phospholipase C
Mayer, B. J., Hamaguchi, M., & Hanafusa, H. (1988) · Nature · doi:10.1038/332272a0 · Cited by 762 · see citing works
Expression cloning of the murine erythropoietin receptor
D’Andrea, A. D., Lodish, H. F., & Wong, G. G. (1989) · Cell · doi:10.1016/0092-8674(89)90965-3 · Cited by 737 · see citing works
Skolnik, E. Y., Lee, C., Batzer, A., Vicentini, L. M., Zhou, M., Daly, R. J., Myers, M. G., Backer, J., Ullrich, A., & White, M. F. (1993) · The EMBO Journal · doi:10.1002/j.1460-2075.1993.tb05842.x · Cited by 693 · see citing works
C. elegans cell-signalling gene sem-5 encodes a protein with SH2 and SH3 domains
Clark, S. G., Stern, M., & Horvritz, H. R. (1992) · Nature · doi:10.1038/356340a0 · Cited by 603 · see citing works
Grb2 mediates the EGF-dependent activation of guanine nucleotide exchange on Ras
Gale, N. W., Kaplan, S., Lowenstein, E. J., Schlessinger, J., & Bar‐Sagi, D. (1993) · Nature · doi:10.1038/363088a0 · Cited by 563 · see citing works
Bazán, J. F. (1989) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(89)91528-3 · Cited by 542 · see citing works
Olivier, J. P. (1993) · Cell · doi:10.1016/0092-8674(93)90170-u · Cited by 537 · see citing works
Simon, M. C. (1993) · Cell · doi:10.1016/0092-8674(93)90169-q · Cited by 452 · see citing works
Insulin-induced phosphorylation of the 46- and 52-kDa Shc proteins.
Pronk, G. J., McGlade, J. C., Pelicci, G., Pawson, T. J., & Bos, J. L. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)53382-2 · Cited by 304 · see citing works
Selective growth response to IL‐3 of a human leukaemic cell line with megakaryoblastic features
Avanzi, G. C., Lista, P., Giovinazzo, B., MINIERO, R., Saglio, G. N., Benetton, G., Coda, R., Cattoretti, G., & Pegoraro, L. (1988) · British Journal of Haematology · doi:10.1111/j.1365-2141.1988.tb02374.x · Cited by 292 · see citing works
The Son of sevenless Gene Product: a Putative Activator of Ras
Bonfini, L., Karlovich, C., Dasgupta, C., & Banerjee, U. K. (1992) · Science · doi:10.1126/science.1736363 · Cited by 274 · see citing works
Tyrosine Kinase-Stimulated Guanine Nucleotide Exchange Activity of Vav in T Cell Activation
Gulbins, E., Coggeshall, K. M., Baier, G., Katzav, S., Burn, P., & Altman, A. (1993) · Science · doi:10.1126/science.8484124 · Cited by 273 · see citing works
Shc proteins are phosphorylated and regulated by the v-Src and v-Fps protein-tyrosine kinases.
McGlade, J. C., Cheng, A. M., Pelicci, G., Pelicci, P. G., & Pawson, T. J. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.19.8869 · Cited by 264 · see citing works
Induction of Tyrosine Phosphorylation by the Erythropoietin Receptor Correlates with Mitogenesis
Miura, O., D’Andrea, A. D., Kabat, D., & Ihle, J. N. (1991) · Molecular and Cellular Biology · doi:10.1128/mcb.11.10.4895 · Cited by 224 · see citing works
Nck, a melanoma cDNA encoding a cytoplasmic protein consisting of the src homology units SH2 and SH3
Lehmann, J. M., Riethmüller, G., & Johnson, J. P. (1990) · Nucleic Acids Research · doi:10.1093/nar/18.4.1048 · Cited by 210 · see citing works
Rogge, R. D., Karlovich, C., & Banerjee, U. K. (1991) · Cell · doi:10.1016/0092-8674(91)90207-f · Cited by 209 · see citing works
Carroll, M. P., Spivak, J. L., McMahon, M., Weich, N. S., Rapp, U. R., & May, W. S. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)98572-8 · Cited by 175 · see citing works
Torti, M., Marti, K. B., Altschuler, D. L., Yamamoto, K., & Lapetina, E. G. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)42441-6 · Cited by 131 · see citing works
Damen, J. E., Mui, A. L.-F., Puil, L. J., Pawson, T. J., & Krystal, G. (1993) · Blood · doi:10.1182/blood.v81.12.3204.3204 · Cited by 127 · see citing works
Self-citationIn Vitro Phosphorylation of the Erythropoietin Receptor and an Associated Protein, pp130
Yoshimura, A., & Lodish, H. F. (1992) · Molecular and Cellular Biology · doi:10.1128/mcb.12.2.706 · Cited by 123 · see citing works
Dusanter‐Fourt, I., Casadevall, N., Lacombe, C., Muller, O., Billat, C., Fischer, S., & Mayeux, P. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)50070-9 · Cited by 119 · see citing works
Quelle, F. W., & Wojchowski, D. M. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)52478-9 · Cited by 110 · see citing works
Epidermal growth factor stimulates the tyrosine phosphorylation of SHC in the mouse.
Ruff-Jamison, S., McGlade, J. C., Pawson, T. J., Chen, K., & Cohen, S. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)52996-3 · Cited by 92 · see citing works
Damen, J. E., Mui, A. L.-F., Hughes, P., Humphries, R. K., & Krystal, G. (1992) · Blood · doi:10.1182/blood.v80.8.1923.1923 · Cited by 67 · see citing works
Self-citationDetection and isolation of the erythropoietin receptor using biotinylated erythropoietin
Wognum, A., Lansdorp, P., Humphries, R. K., & Krystal, G. (1990) · Blood · doi:10.1182/blood.v76.4.697.697 · Cited by 64 · see citing works
Self-citationKomatsu, N., Adamson, J., Yamamoto, K., Altschuler, D. L., Torti, M., Marzocchini, R., & Lapetina, E. (1992) · Blood · doi:10.1182/blood.v80.1.53.53 · Cited by 47 · see citing works
Sawada, T., Tsuda, H., Kawakita, M., & Takatsuki, K. (1992) · PubMed · Cited by 4 · see citing works
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Multiple Myeloma: Increasing Evidence for a Multistep Transformation Process
Hallek, M. J., Bergsagel, P. L., & Anderson, K. C. (1998) · Blood · doi:10.1182/blood.v91.1.3 · Cited by 747 · see citing works
Small Peptides as Potent Mimetics of the Protein Hormone Erythropoietin
Wrighton, N. C., Farrell, F. X., Chang, R., Kashyap, A. K., Barbone, F. P., Mulcahy, L. S., Johnson, D. L., Barrett, R. W., Jolliffe, L. K., & Dower, W. J. (1996) · Science · doi:10.1126/science.273.5274.458 · Cited by 672 · see citing works
Signaling by the cytokine receptor superfamily: JAKs and STATs
Ihle, J. N., Witthuhn, B. A., Quelle, F. W., Yamamoto, K., Thierfelder, W. E., Kreider, B. L., & Silvennoinen, O. (1994) · Trends in Biochemical Sciences · doi:10.1016/0968-0004(94)90026-4 · Cited by 648 · see citing works
Damen, J. E., Liu, L., Rosten, P., Humphries, R. K., Jefferson, A. B., Majerus, P. W., & Krystal, G. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.4.1689 · Cited by 633 · see citing works
Self-citationSignaling Through the Hematopoietic Cytokine Receptors
Ihle, J. N., Witthuhn, B. A., Quelle, F. W., Yamamoto, K., & Silvennoinen, O. (1995) · Annual Review of Immunology · doi:10.1146/annurev.iy.13.040195.002101 · Cited by 612 · see citing works
Helgason, C. D., Damen, J. E., Rosten, P., Grewal, R., Sorensen, P., Chappel, S. M., Borowski, A., Jirik, F., Krystal, G., & Humphries, R. K. (1998) · Genes & Development · doi:10.1101/gad.12.11.1610 · Cited by 556 · see citing works
Self-citationSignaling via Shc family adapter proteins
Ravichandran, K. S. (2001) · Oncogene · doi:10.1038/sj.onc.1204776 · Cited by 424 · see citing works
p150Ship, a signal transduction molecule with inositol polyphosphate-5-phosphatase activity.
Lioubin, M. N., Algate, P. A., Tsai, S., Carlberg, K., Aebersold, A., & Rohrschneider, L. R. (1996) · Genes & Development · doi:10.1101/gad.10.9.1084 · Cited by 418 · see citing works
Migliaccio, E., Mele, S., Salcini, A. E., Pelicci, G., Lai, K. V., Superti‐Furga, G., Pawson, T. J., Fiore, P. P. D., Lanfrancone, L., & Pelicci, P. G. (1997) · The EMBO Journal · doi:10.1093/emboj/16.4.706 · Cited by 395 · see citing works
Liu, Q., Sasaki, T., Kozieradzki, I., Wakeham, A., Itie, A., Dumont, D. J., & Penninger, J. M. (1999) · Genes & Development · doi:10.1101/gad.13.7.786 · Cited by 341 · see citing works
Structure, function, and biology of SHIP proteins
Rohrschneider, L. R., Fuller, J. F., Wolf, I., Liu, Y., & Lucas, D. M. (2000) · Genes & Development · doi:10.1101/gad.14.5.505 · Cited by 294 · see citing works
Molecular analysis of the granulocyte colony-stimulating factor receptor
Avalos, B. (1996) · Blood · doi:10.1182/blood.v88.3.761.bloodjournal883761 · Cited by 293 · see citing works
Jiao, H., Berrada, K., Yang, W., Tabrizi, M. H., Platanias, L. C., & Yi, T. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.12.6985 · Cited by 290 · see citing works
Damen, J. E., Wakao, H., Miyajima, A., Krošl, J., Humphries, R. K., Cutler, R. L., & Krystal, G. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb00243.x · Cited by 275 · see citing works
Self-citationHematopoietic Growth Factors Signal Through the Formation of Reactive Oxygen Species
Sattler, M., Winkler, T., Verma, S., Byrne, C. H., Shrikhande, G., Salgia, R., & Griffin, J. D. (1999) · Blood · doi:10.1182/blood.v93.9.2928 · Cited by 254 · see citing works
Cutler, R. L., Liu, L., Damen, J. E., & Krystal, G. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)80558-4 · Cited by 228 · see citing works
Self-citationSignal Transduction in the Erythropoietin Receptor System
Wojchowski, D. M., Gregory, R. C., Miller, C. P., Pandit, A. K., & Pircher, T. J. (1999) · Experimental Cell Research · doi:10.1006/excr.1999.4673 · Cited by 227 · see citing works
The c-Mpl Ligand (Thrombopoietin) Stimulates Tyrosine Phosphorylation of Jak2, Shc, and c-Mpl
Drachman, J. G., Griffin, J. D., & Kaushansky, K. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.10.4979 · Cited by 223 · see citing works
The Janus protein tyrosine kinase family and its role in cytokine signaling.
Ihle, J. (1995) · Advances in Immunology · doi:10.1016/s0065-2776(08)60582-9 · Cited by 225 · see citing works
Interleukin 2 and erythropoietin activate STAT5/MGF via distinct pathways.
Wakao, H., Harada, N., Kitamura, T., Mui, A., & Miyajima, A. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb07250.x · Cited by 209 · see citing works
Liu, Q., Oliveira-dos-Santos, A., Mariathasan, S., Bouchard, D., Jones, J. V., Sarao, R., Kozieradzki, I., Ohashi, P. S., Penninger, J. M., & Dumont, D. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.188.7.1333 · Cited by 205 · see citing works
Liu, L., Damen, J. E., Cutler, R. L., & Krystal, G. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.10.6926 · Cited by 181 · see citing works
Self-citationOdai, H., Sasaki, K., Iwamatsu, A., Hanazono, Y., Tanaka, T., Mitani, K., Yazaki, Y., & Hirai, H. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.18.10800 · Cited by 177 · see citing works
Klingmüller, U., Wu, H., Hsiao, J. G., Toker, A., Duckworth, B. C., Cantley, L. C., & Lodish, H. F. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.7.3016 · Cited by 172 · see citing works
Interaction of Shc with Grb2 Regulates Association of Grb2 with mSOS
Ravichandran, K. S., Lorenz, U. M., Shoelson, S. E., & Burakoff, S. J. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.2.593 · Cited by 170 · see citing works
Growth Hormone-promoted Tyrosyl Phosphorylation of SHC Proteins and SHC Association with Grb2
VanderKuur, J. A., Allevato, G., Billestrup, N., Norstedt, G., & Carter‐Su, C. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.13.7587 · Cited by 160 · see citing works
Sui, X., Krantz, S. B., You, M., & Zhao, Z. J. (1998) · Blood · doi:10.1182/blood.v92.4.1142 · Cited by 158 · see citing works
Uddin, S., Ah-Kang, J., Ulaszek, J., Mahmud, D., & Wickrema, A. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0307075101 · Cited by 151 · see citing works
Liang, K., Esteva, F. J., Albarracin, C., Stemke-Hale, K., Lu, Y., Bianchini, G., Yang, C.-Y., Li, Y., Li, X., Chen, C.-T., et al. (2010) · Cancer Cell · doi:10.1016/j.ccr.2010.10.025 · Cited by 139 · see citing works
Tauchi, T., Feng, G., Shen, R., Hoatlin, M. E., Bagby, G. C., Kabat, D., Lu, L., & Broxmeyer, H. E. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.10.5631 · Cited by 139 · see citing works
Damen, J. E., Cutler, R. L., Jiao, H., Yi, T., & Krystal, G. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.40.23402 · Cited by 136 · see citing works
Self-citationErythropoietin protects against diabetes through direct effects on pancreatic β cells
Choi, D., Schroer, S. A., Lu, S. Y., Wang, L., Wu, X., Liu, Y., Zhang, Y., Gaisano, H. Y., Wagner, K., Wu, H., et al. (2010) · The Journal of Experimental Medicine · doi:10.1084/jem.20100665 · Cited by 128 · see citing works
Liu, L., Damen, J. E., Hughes, M. R., Babić, I., Jirik, F. R., & Krystal, G. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.14.8983 · Cited by 119 · see citing works
Self-citationTridandapani, S., Kelley, T. W., Pradhan, M., Cooney, D. S., Justement, L. B., & Coggeshall, K. M. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.8.4305 · Cited by 116 · see citing works
Molecular Mechanisms of Trastuzumab Resistance in HER2 Overexpressing Breast Cancer
Fiszman, G. L., & Jasnis, M. A. (2011) · International Journal of Breast Cancer · doi:10.4061/2011/352182 · Cited by 119 · see citing works
Lamkin, T. D., Walk, S. F., Liu, L., Damen, J. E., Krystal, G., & Ravichandran, K. S. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.16.10396 · Cited by 118 · see citing works
Self-citationThe Role of Tyrosine Phosphorylation in Proliferation and Maturation of Erythroid Progenitor Cells
Klingmüller, U. (1997) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1997.t01-1-00637.x · Cited by 116 · see citing works
Lioubin, M. N., Myles, G. M., Carlberg, K., Bowtell, D. D. L., & Rohrschneider, L. R. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.9.5682-5691.1994 · Cited by 117 · see citing works
Chen, Y., Grall, D., Salcini, A. E., Pelicci, P. G., Pouysségur, J., & Obberghen‐Schilling, E. V. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00441.x · Cited by 111 · see citing works
Gupta, S., Weiss, A., Kumar, G., Wang, S., & Nel, A. E. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)32560-7 · Cited by 109 · see citing works
Hunter, M. G., & Avalos, B. R. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.160.10.4979 · Cited by 106 · see citing works
Dolznig, H., Boulmé, F., Stangl, K., Deiner, E. M., Mikulits, W., Beug, H., & Müllner, E. W. (2001) · The FASEB Journal · doi:10.1096/fj.00-0705fje · Cited by 105 · see citing works
O’Bryan, J. P., Songyang, Z., Cantley, L. C., Der, C. J., & Pawson, T. J. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.7.2729 · Cited by 107 · see citing works
Jacobs-Helber, S. M., Wickrema, A., Birrer, M. J., & Sawyer, S. T. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.7.3699 · Cited by 101 · see citing works
Welham, M. J., Duronio, V., Leslie, K. B., Bowtell, D. D. L., & Schrader, J. W. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)31944-0 · Cited by 100 · see citing works
Engagement of Gab1 and Gab2 in Erythropoietin Signaling
Wickrema, A., Shahab Uddin, M. S., Sharma, A. K., Chen, F., Alsayed, Y. M., Ahmad, S., Sawyer, S. T., Krystal, G., Yi, T., Nishada, K., et al. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.35.24469 · Cited by 97 · see citing works
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Verdier, F., Chrétien, S., Billat, C., Gisselbrecht, S., Lacombe, C., & Mayeux, P. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.42.26173 · Cited by 97 · see citing works
Ware, M., Rosten, P., Damen, J., Liu, L., Humphries, R., & Krystal, G. (1996) · Blood · doi:10.1182/blood.v88.8.2833.bloodjournal8882833 · Cited by 96 · see citing works
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Liu, Q., Shalaby, F., Jones, J., Bouchard, D., & Dumont, D. J. (1998) · Blood · doi:10.1182/blood.v91.8.2753.2753_2753_2759 · Cited by 95 · see citing works
Tauchi, T., Damen, J. E., Toyama, K., Feng, G., Broxmeyer, H., & Krystal, G. (1996) · Blood · doi:10.1182/blood.v87.11.4495.bloodjournal87114495 · Cited by 95 · see citing works
Self-citationBarber, D. L., Mason, J. M., Fukazawa, T., Reedquist, K. A., Druker, B. J., Band, H., & D’Andrea, A. D. (1997) · Blood · doi:10.1182/blood.v89.9.3166 · Cited by 92 · see citing works
Myklebust, J. H., Blomhoff, H. K., Rusten, L. S., Stokke, T., & Smeland, E. B. (2002) · Experimental Hematology · doi:10.1016/s0301-472x(02)00868-8 · Cited by 89 · see citing works
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Jacobs-Helber, S. M., Penta, K., Sun, Z., Lawson, A. E., & Sawyer, S. T. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.11.6850 · Cited by 89 · see citing works
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Marrero, M. B., Venema, R. C., Ma, H., Ling, B. N., & Eaton, D. C. (1998) · Kidney International · doi:10.1046/j.1523-1755.1998.00887.x · Cited by 85 · see citing works
Crowley, M. T., Harmer, S. L., & DeFranco, A. L. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.2.1145 · Cited by 85 · see citing works
Erythropoietin induces cancer cell resistance to ionizing radiation and to cisplatin
Belenkov, S., Shenouda, G., Rizhevskaya, E., Cournoyer, D., Belzile, J.-P., Souhami, L., Dević, S., & Chow, T. Y.-K. (2004) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.1525.3.12 · Cited by 83 · see citing works
Multimeric cytokine receptors: common versus specific functions
Sato, N., & Miyajima, A. (1994) · Current Opinion in Cell Biology · doi:10.1016/0955-0674(94)90133-3 · Cited by 83 · see citing works
Missense mutation of the erythropoietin receptor is a rare event in human erythroid malignancies
Couedic, J. L., Mitjavila, M. T., Villeval, J., Féger, F., Gobert, S., Mayeux, P., Casadevall, N., & Vainchenker, W. (1996) · Blood · doi:10.1182/blood.v87.4.1502.bloodjournal8741502 · Cited by 79 · see citing works
Negative signaling in B cells: SHIP Grbs Shc
Tridandapani, S., Kelley, T. W., Cooney, D. S., Pradhan, M., & Coggeshall, K. M. (1997) · Immunology Today · doi:10.1016/s0167-5699(97)01112-2 · Cited by 76 · see citing works
Schmandt, R. E., Liu, S. K., & McGlade, C. J. (1999) · Oncogene · doi:10.1038/sj.onc.1202507 · Cited by 74 · see citing works
Conti, L., De‐Fraja, C., Gulisano, M., Migliaccio, E., Govoni, S. M., & Cattaneo, E. F. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.15.8185 · Cited by 75 · see citing works
Janus kinases in cytokine signalling.
Ihle, J. (1996) · Philosophical transactions of the Royal Society of London. Series B, Biological sciences · doi:10.1098/rstb.1996.0012 · Cited by 81 · see citing works
Protein Kinase C α Controls Erythropoietin Receptor Signaling
Lindern, M. V., Amelsvoort, M. P.-V., van Dijk, T., Deiner, E., van den Akker, E., Vries, S. E. V. E., Willems, P. H. G. M., Beug, H., & Löwenberg, B. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m007042200 · Cited by 75 · see citing works
Lioubin, M. N., Myles, G. M., Carlberg, K., Bowtell, D. D. L., & Rohrschneider, L. R. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.9.5682 · Cited by 74 · see citing works
Lotti, L. V., Lanfrancone, L., Migliaccio, E., Zompetta, C., Pelicci, G., Salcini, A. E., Falini, B., Pelicci, P. G., & Torrisi, M. R. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.5.1946 · Cited by 73 · see citing works
Analysis of Interleukin-2-dependent Signal Transduction through the Shc/Grb2 Adapter Pathway
Evans, G. A., Goldsmith, M. A., Johnston, J. A., Xu, W., Weiler, S. R., Erwin, R. A., Howard, O. M. Z., Abraham, R. T., O’Shea, J. J., Greene, W. C., et al. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.48.28858 · Cited by 72 · see citing works
Signaling by the cytokine receptor superfamily in normal and transformed hematopoietic cells.
Ihle, J. (1996) · Advances in Cancer Research · doi:10.1016/s0065-230x(08)60351-6 · Cited by 74 · see citing works
Ohashi, T., Masuda, M., & Ruscetti, S. K. (1995) · Blood · doi:10.1182/blood.v85.6.1454.bloodjournal8561454 · Cited by 72 · see citing works
Activation of the transcription factor NF-κB by the erythropoietin receptor
Bittorf, T., Büchse, T., Sasse, T., Jaster, R., & Brock, J. (2001) · Cellular Signalling · doi:10.1016/s0898-6568(01)00189-9 · Cited by 70 · see citing works
Pruett, W., Yuan, Y. P., Rose, E., Batzer, A., Harada, N., & Skolnik, E. Y. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.3.1778 · Cited by 69 · see citing works
Damen, J. E., Liu, L., Ware, M. D., Ermolaeva, M. V., Majerus, P. W., & Krystal, G. (1998) · Blood · doi:10.1182/blood.v92.4.1199 · Cited by 68 · see citing works
Self-citationDeregulation of erythropoiesis by the Friend spleen focus-forming virus
Ruscetti, S. K. (1999) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/s1357-2725(99)00074-6 · Cited by 66 · see citing works
Molecular Mechanisms of Erythropoietin Signaling
Cheung, J. Y., & Miller, B. A. (2001) · The Nephron journals/Nephron journals · doi:10.1159/000045918 · Cited by 66 · see citing works
Gobert, S., Duprez, V., Lacombe, C., Gisselbrecht, S., & Mayeux, P. (1995) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1995.075_c.x · Cited by 65 · see citing works
Core erythropoietin receptor signals for late erythroblast development
Menon, M. P., Fang, J., & Wojchowski, D. M. (2005) · Blood · doi:10.1182/blood-2005-02-0684 · Cited by 64 · see citing works
Co-stimulation-dependent activation of a JNK-kinase in T lymphocytes
Avraham, A., Jung, S., Samuels, Y., Seger, R., & Ben‐Neriah, Y. (1998) · European Journal of Immunology · doi:10.1002/(sici)1521-4141(199808)28:08 · Cited by 71 · see citing works
The role of SHIP in growth factor induced signalling
Huber, M., Helgason, C. D., Damen, J. E., Scheid, M. P., Duronio, V., Liu, L., Ware, M. D., Humphries, R. K., & Krystal, G. (1999) · Progress in Biophysics and Molecular Biology · doi:10.1016/s0079-6107(98)00049-2 · Cited by 62 · see citing works
Self-citationRas activation in normal white blood cells and childhood acute lymphoblastic leukemia.
von Lintig, F. C., Huvar, I., Law, P., Diccianni, M. B., Yu, A. L.-T., & Boss, G. R. (2000) · PubMed · Cited by 61 · see citing works
Aman, M. J., Walk, S. F., March, M., Su, H.-P., Carver, D. J., & Ravichandran, K. S. (2000) · Molecular and Cellular Biology · doi:10.1128/.20.10.3576-3589.2000 · Cited by 61 · see citing works
He, T., Jiang, N., Zhuang, H., Quelle, D. E., & Wojchowski, D. M. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)32302-5 · Cited by 59 · see citing works
Modulation of Calcium Channels in Human Erythroblasts by Erythropoietin
Cheung, J. Y., Zhang, X.-Q., Bokvist, K. B., Tillotson, D. L., & Miller, B. A. (1997) · Blood · doi:10.1182/blood.v89.1.92 · Cited by 57 · see citing works
Pedraza‐Alva, G., de Long, L. M., Burakoff, S. J., & Rosenstein, Y. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.23.14218 · Cited by 56 · see citing works
Morita, H., Tahara, T., Matsumoto, A., Kato, T., Miyazaki, H., & Ohashi, H. (1996) · FEBS Letters · doi:10.1016/0014-5793(96)01047-2 · Cited by 55 · see citing works
Nishigaki, K., Hanson, C. A., Ohashi, T., Thompson, D. M., Muszynski, K. W., & Ruscetti, S. K. (2000) · Journal of Virology · doi:10.1128/jvi.74.7.3037-3045.2000 · Cited by 55 · see citing works
A Novel Spliced Form of SH2-Containing Inositol Phosphatase Is Expressed During Myeloid Development
Lucas, D. M., & Rohrschneider, L. R. (1999) · Blood · doi:10.1182/blood.v93.6.1922.406k21_1922_1933 · Cited by 54 · see citing works
Lankester, A. C., van Schijndel, G. M. W., Rood, P. M. L., Verhoeven, A. J., & van Lier, R. A. W. (1994) · European Journal of Immunology · doi:10.1002/eji.1830241136 · Cited by 54 · see citing works
Gobert, S., Porteu, F., Pallu, S., Muller, O., Sabbah, M., Dusanter‐Fourt, I., Courtois, G., Lacombe, C., Gisselbrecht, S., & Mayeux, P. (1995) · Blood · doi:10.1182/blood.v86.2.598.bloodjournal862598 · Cited by 54 · see citing works
Shigematsu, H., Iwasaki, H., Otsuka, T., Ohno, Y., Arima, F., & Niho, Y. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.22.14334 · Cited by 52 · see citing works
Barber, D. L., DeMartino, J. C., Showers, M. O., & D’Andrea, A. D. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.4.2257 · Cited by 52 · see citing works
Mu, S., Xia, M., Elliott, G., Bogenberger, J., Swift, S. E., Bennett, L., Lappinga, D., Hecht, R. M., Lee, R., & Saris, C. P. (1995) · Blood · doi:10.1182/blood.v86.12.4532.bloodjournal86124532 · Cited by 52 · see citing works
Signal Transduction Pathways Regulating Hematopoietic Differentiation
Smithgall, T. E. (1998) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01346-2 · Cited by 50 · see citing works
Mason, J. M., Beattie, B. K., Liu, Q., Dumont, D., & Barber, D. L. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.6.4398 · Cited by 50 · see citing works
Erythropoietin Activates Raf1 by an Shc-Independent Pathway in CTLL-EPO-R Cells
Barber, D. L., Corless, C. N., Xia, K., Roberts, T. M., & D’Andrea, A. D. (1997) · Blood · doi:10.1182/blood.v89.1.55 · Cited by 48 · see citing works
Jacobs-Helber, S. M., & Sawyer, S. T. (2004) · Blood · doi:10.1182/blood-2003-05-1754 · Cited by 48 · see citing works
Barber, D. L., Beattie, B. K., Mason, J. M., Nguyen, M. H.-H., Yoakim, M., Neel, B. G., D’Andrea, A. D., & Frank, D. A. (2001) · Blood · doi:10.1182/blood.v97.8.2230 · Cited by 45 · see citing works
Dai, C., Krantz, S. B., & Sawyer, S. T. (1997) · Blood · doi:10.1182/blood.v89.10.3574 · Cited by 45 · see citing works
Role of Gab proteins in phosphatidylinositol 3-kinase activation by thrombopoietin (Tpo)
Bouscary, D., Lecoq‐Lafon, C., Chrétien, S., Zompì, S., Fichelson, S., Muller, O., Porteu, F., Dusanter‐Fourt, I., Gisselbrecht, S., Mayeux, P., et al. (2001) · Oncogene · doi:10.1038/sj.onc.1204317 · Cited by 44 · see citing works
Requirement for JAK2 inErythropoietin-Induced Signalling Pathways
Bittorf, T., Jaster, R., Lüdtke, B., Kamper, B., & Brock, J. (1997) · Cellular Signalling · doi:10.1016/s0898-6568(96)00121-0 · Cited by 44 · see citing works
- Authors
- Damen, J., Liu, L., Cutler, R., & Krystal, G.
- Affiliations
- Terry Fox Laboratory, B.C. Cancer Agency, Vancouver, Canada.
- BC Cancer Agency (CA)
- ORCID
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 1993-10-15
- Volume
- 82
- Issue
- 8
- Pages
- 2296-2303
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W50290146
- Cited by
- 193
- References
- 36
- Citations by year
- 2026: 1 · 2023: 3 · 2022: 1 · 2018: 1 · 2017: 2 · 2012: 4
- FWCI
- 13.78
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Blood (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Hematology › Erythropoietin and Anemia Treatment
- Health Sciences › Medicine › Oncology › Cytokine Signaling Pathways and Interactions
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Tyrosine Phosphatases
- Keywords
- erythropoietin, erythropoietin receptor, Shc, Grb2, tyrosine phosphorylation, signal transduction, Ras activation, receptor tyrosine kinase, MO7e cells
- MeSH terms
- Src Homology 2 Domain-Containing, Transforming Protein 1, Animals, Cell Line, Erythropoietin, Cricetinae, Humans, Molecular Weight, Phosphoproteins, Phosphorylation, Proteins, Tyrosine, Oncogene Proteins, Receptors, Erythropoietin, Adaptor Proteins, Vesicular Transport, Adaptor Proteins, Signal Transducing, Mice, Shc Signaling Adaptor Proteins
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