Klein, Ophir D.

Opposing activities of Notch and Wnt signaling regulate intestinal stem cells and gut homeostasis

Tian, H., Biehs, B., Chiu, C., Siebel, C. W., Wu, Y., Costa, M., de Sauvage, F. J., & Klein, O. D. (2015) · Cell Reports

Wnt/β-catenin signaling in development and cancerDevelopmental Biology and Gene Regulation

Cited by 214

A genome-wide association study identifies susceptibility loci for nonsyndromic sagittal craniosynostosis near BMP2 and within BBS9

Justice, C. M., Yagnik, G., Kim, Y., Peter, I., Jabs, E. W., Erazo, M., Ye, X., Ainehsazan, E., Shi, L., Cunningham, M. L., et al. (2012) · Nature Genetics

Craniofacial Disorders and TreatmentsGenomics and Rare Diseases

Cited by 140

Precise modulation of transcription factor levels identifies features underlying dosage sensitivity

Naqvi, S., Kim, S., Hoskens, H., Matthews, H. S., Spritz, R. A., Klein, O. D., Hallgrímsson, B., Swigut, T., Claes, P., Pritchard, J. K., et al. (2023) · Nature Genetics

Genomics and Chromatin DynamicsGene Regulatory Network Analysis

Cited by 132

High-risk additional chromosomal abnormalities at low blast counts herald death by CML

Hehlmann, R., Voskanyan, A., Lauseker, M., Pfirrmann, M., Kalmanti, L., Rinaldetti, S., Kohlbrenner, K., Haferlach, C., Schlegelberger, B., Fabarius, A., et al. (2020) · Leukemia

Chronic Myeloid Leukemia TreatmentsAcute Myeloid Leukemia Research

Cited by 91

Prenatal β-catenin/Brn2/Tbr2 transcriptional cascade regulates adult social and stereotypic behaviors

Belinson, H., Nakatani, J., Babineau, B. A., Birnbaum, R. Y., Ellegood, J., Bershteyn, M., McEvilly, R. J., Long, J. M., Willert, K., Klein, O. D., et al. (2016) · Molecular Psychiatry

Genetics and Neurodevelopmental DisordersNeurogenesis and neuroplasticity mechanisms

Cited by 79

Epithelial WNT ligands are essential drivers of intestinal stem cell activation

Zou, W. Y., Blutt, S. E., Zeng, X.-L., Chen, M.-S., Lo, Y.-H., Castillo-Azofeifa, D., Klein, O. D., Shroyer, N. F., Donowitz, M., & Estes, M. K. (2018) · Cell Reports

Wnt/β-catenin signaling in development and cancerDigestive system and related health

Cited by 73

A review of craniofacial and dental findings of the RASopathies

Cao, H., Alrejaye, N., Klein, O. D., Goodwin, A. F., & Oberoi, S. (2017) · Orthodontics & Craniofacial Research

dental development and anomaliesProtein Tyrosine Phosphatases

Cited by 63