Cited by 73Wnt/β-catenin signaling in development and cancerDigestive system and related healthHair Growth and Disorders

Epithelial WNT ligands are essential drivers of intestinal stem cell activation

Open access
Zou, Winnie Y., Blutt, Sarah E., Zeng, Xi-Lei, Chen, Min-Shan, Lo, Yuan-Hung, Castillo-Azofeifa, David, Klein, Ophir D., Shroyer, Noah F. +2 more·2018·Cell Reports

Abstract

Intestinal stem cells (ISCs) maintain and repair the intestinal epithelium. While regeneration after ISC-targeted damage is increasingly understood, injury-repair mechanisms that direct regeneration following injuries to differentiated cells remain uncharacterized. The enteric pathogen, rotavirus, infects and damages differentiated cells while sparing all ISC populations, thus allowing the unique examination of the response of intact ISC compartments during injury-repair. Upon rotavirus infection in mice, ISC compartments robustly expand and proliferating cells rapidly migrate. Infection results specifically in stimulation of the active crypt-based columnar ISCs, but not alternative reserve ISC populations, as is observed after ISC-targeted damage. Conditional ablation of epithelial WNT secretion diminishes crypt expansion and ISC activation, demonstrating a previously unknown function of epithelial-secreted WNT during injury-repair. These findings indicate a hierarchical preference of crypt-based columnar cells (CBCs) over other potential ISC populations during epithelial restitution and the importance of epithelial-derived signals in regulating ISC behavior.

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Crossref · 10.1016/j.celrep.2017.12.093

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  • Murine muscle stem cells (MuSCs) experience a transition from quiescence to activation that is required for regeneration.

    “Murine muscle stem cells (MuSCs) experience a transition from quiescence to activation that is required for regeneration, but it remains unknown if the trajectory and dynamics of activation change with age.”

    From Aging induces aberrant state transition kinetics in murine muscle stem cells (2020) · cites this paper as Zou et al., 2018

  • Impaired stem cell activation impairs regenerative potential in multiple tissues.

    “Impaired stem cell activation has been shown to impair regenerative potential in multiple tissues (Megeney et al., 1996; Zou et al., 2018).”

    From Aging induces aberrant state transition kinetics in murine muscle stem cells (2020) · cites this paper as Zou et al., 2018

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Authors
Zou, W. Y., Blutt, S. E., Zeng, X.-L., Chen, M.-S., Lo, Y.-H., Castillo-Azofeifa, D., Klein, O. D., Shroyer, N. F., Donowitz, M., & Estes, M. K.
Affiliations
  • Baylor College of Medicine (US)
  • University of California, San Francisco (US)
  • Johns Hopkins University (US)
Corresponding author
Estes, Mary K.
Venue
Cell Reports
Publisher
Elsevier BV
Published
2018-01
Volume
22
Issue
4
Pages
1003-1015
ISSN
2211-1247 (ISSN-L)
OpenAlex
W2784946434
Cited by
73
References
89
Citations by year
2026: 4 · 2025: 7 · 2024: 12 · 2023: 9 · 2022: 4 · 2021: 10 · 2020: 10 · 2019: 11 · 2018: 5
FWCI
3.20
Type
journal article
Language
en
Open access
Locations
  • Cell Reports (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • eScholarship (California Digital Library) (submittedVersion, cc-by-nc-nd)
Funders
  • Dan L. Duncan Cancer Center, Baylor College of Medicine
  • John S. Dunn Foundation (CPRIT RP150578)
  • National Center for Research Resources (S10RR024574, RP150578, DK56338, CA125123)
  • National Cancer Institute (P30CA125123)
  • Baylor College of Medicine
  • National Institutes of Health (U01 DK103168, U01 DK103168-03S1, F30 DK107173, U01 DK103168-02S1)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Digestive system and related health
  • Health Sciences › Medicine › Urology › Hair Growth and Disorders
Keywords
intestinal stem cells, rotavirus infection, epithelial restitution, Wnt ligands, stem cell activation, epithelial regeneration
MeSH terms
Animals, Epithelial Cells, Intestinal Mucosa, Ligands, Stem Cells, Mice

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