Henning, Nathaniel J.

Advances in covalent drug discovery

Boike, L., Henning, N. J., & Nomura, D. K. (2022) · Nature Reviews Drug Discovery

Click Chemistry and ApplicationsProtein Degradation and Inhibitors

Cited by 823

Deubiquitinase-targeting chimeras for targeted protein stabilization

Henning, N. J., Boike, L., Spradlin, J. N., Ward, C. C., Liu, G., Zhang, E., Belcher, B. P., Brittain, S. M., Hesse, M. J., Dovala, D., et al. (2022) · Nature Chemical Biology

Protein Degradation and InhibitorsUbiquitin and proteasome pathways

Cited by 344

Discovery of a Covalent FEM1B Recruiter for Targeted Protein Degradation Applications

Henning, N. J., Manford, A. G., Spradlin, J. N., Brittain, S. M., Zhang, E., McKenna, J. M., Tallarico, J. A., Schirle, M., Rape, M., & Nomura, D. K. (2022) · Journal of the American Chemical Society

Protein Degradation and InhibitorsUbiquitin and proteasome pathways

Cited by 221

Discovery of a Functional Covalent Ligand Targeting an Intrinsically Disordered Cysteine within MYC

Boike, L., Cioffi, A. G., Majewski, F. C., Co, J., Henning, N. J., Jones, M. D., Liu, G., McKenna, J. M., Tallarico, J. A., Schirle, M., et al. (2021) · Cell Chemical Biology

Protein Degradation and InhibitorsClick Chemistry and Applications

Cited by 154

Structure-Based Design of a Potent and Selective Covalent Inhibitor for SRC Kinase That Targets a P-Loop Cysteine

Du, G., Rao, S., Gurbani, D., Henning, N. J., Jiang, J., Che, J., Yang, A., Ficarro, S. B., Marto, J. A., Aguirre, A. J., et al. (2020) · Journal of Medicinal Chemistry

Heterocyclic Compound Synthesis and BioactivityProtein Kinase Regulation and GTPase Signaling

Cited by 39

Structure and Characterization of a Covalent Inhibitor of Src Kinase

Gurbani, D., Du, G., Henning, N. J., Rao, S., Bera, A. K., Zhang, T., Gray, N. S., & Westover, K. D. (2020) · Frontiers in Molecular Biosciences

Protein Kinase Regulation and GTPase SignalingCancer Mechanisms and Therapy

Cited by 29