Speck, Nancy A.

Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesis.

Wang, Q., Stacy, T., Binder, M., Marin-Padilla, M., Sharpe, A. H., & Speck, N. A. (1996) · Proceedings of the National Academy of Sciences

Acute Myeloid Leukemia ResearchHematopoietic Stem Cell Transplantation

Cited by 1,178

Haploinsufficiency of CBFA2 causes familial thrombocytopenia with propensity to develop acute myelogenous leukaemia

Song, W.-J., Sullivan, M. G., Legare, R. D., Hutchings, S., Tan, X., Kufrin, D., Ratajczak, J., Resende, I. C., Haworth, C., Hock, R., et al. (1999) · Nature Genetics

Platelet Disorders and TreatmentsAcute Myeloid Leukemia Research

Cited by 1,100

Of lineage and legacy: the development of mammalian hematopoietic stem cells

Dzierzak, E., & Speck, N. A. (2008) · Nature Immunology

Hematopoietic Stem Cell TransplantationDevelopmental Biology and Gene Regulation

Cited by 707

Cbfa2 is required for the formation of intra-aortic hematopoietic clusters

North, T., Gu, T.-L., Stacy, T., Wang, Q., Howard, L., Binder, M., Marín-Padilla, M., & Speck, N. A. (1999) · Development

Hematopoietic Stem Cell TransplantationDevelopmental Biology and Gene Regulation

Cited by 662

The CBFβ Subunit Is Essential for CBFα2 (AML1) Function In Vivo

Wang, Q., Stacy, T., Miller, J. D., Lewis, A. F., Gu, T.-L., Huang, X., Bushweller, J. H., Bories, J.-C., Alt, F. W., Ryan, G., et al. (1996) · Cell

Acute Myeloid Leukemia ResearchRetinoids in leukemia and cellular processes

Cited by 621

Loss of Runx1 perturbs adult hematopoiesis and is associated with a myeloproliferative phenotype

Growney, J. D., Shigematsu, H., Li, Z., Lee, B. H., Adelsperger, J., Rowan, R., Curley, D. P., Kutok, J. L., Akashi, K., Williams, I. R., et al. (2005) · Blood

Hematopoietic Stem Cell TransplantationAcute Myeloid Leukemia Research

Cited by 462

Cloning and Characterization of Subunits of the T-Cell Receptor and Murine Leukemia Virus Enhancer Core-Binding Factor

Wang, S., Wang, Q., Crute, B. E., Melnikova, I. N., Keller, S. R., & Speck, N. A. (1993) · Molecular and Cellular Biology

T-cell and Retrovirus StudiesGenomics and Chromatin Dynamics

Cited by 435

Embryonic lethality and impairment of haematopoiesis in mice heterozygous for an AML1-ETO fusion gene

Yergeau, D. A., Hetherington, C. J., Wang, Q., Zhang, P., Sharpe, A. H., Binder, M., Marín-Padilla, M., Tenen, D. G., Speck, N. A., & Zhang, D.-E. (1997) · Nature Genetics

Acute Myeloid Leukemia ResearchRetinoids in leukemia and cellular processes

Cited by 346

Failure of Embryonic Hematopoiesis andLethal Hemorrhages in Mouse Embryos Heterozygousfor a Knocked-In Leukemia Gene CBFB–MYH11

Castilla, L. H., Wijmenga, C., Wang, Q., Stacy, T., Speck, N. A., Eckhaus, M., Marín-Padilla, M., Collins, F. S., Wynshaw-Boris, A., & Liu, P. P. (1996) · Cell

Acute Myeloid Leukemia ResearchHematopoietic Stem Cell Transplantation

Cited by 284

PU.1 is a major downstream target of AML1 (RUNX1) in adult mouse hematopoiesis.

Huang, G., Zhang, P., Hirai, H., Elf, S., Yan, X., Chen, Z., Koschmieder, S., Okuno, Y., Dayaram, T., Growney, J. D., et al. (2008) · Nature Genetics

Genomics and Chromatin DynamicsAcute Myeloid Leukemia Research

Cited by 259

Cooperative binding of Ets-1 and core binding factor to DNA.

Wotton, D., Ghysdael, J., Wang, S., Speck, N. A., & Owen, M. J. (1994) · Molecular and Cellular Biology

Genomics and Chromatin DynamicsDiffusion and Search Dynamics

Cited by 216

DNA Specificity Determinants Associate with Distinct Transcription Factor Functions

Hollenhorst, P. C., Chandler, K. J., Poulsen, R. L., Johnson, W. E., Speck, N. A., & Graves, B. J. (2009) · PLoS Genetics

Genomics and Chromatin DynamicsChromatin Remodeling and Cancer

Cited by 198

Auto-Inhibition and Partner Proteins, Core-Binding Factor β (CBFβ) and Ets-1, Modulate DNA Binding by CBFα2 (AML1)

Gu, T.-L., Goetz, T. L., Graves, B. J., & Speck, N. A. (2000) · Molecular and Cellular Biology

Genomics and Chromatin DynamicsAcute Myeloid Leukemia Research

Cited by 150

The Leukemic Protein Core Binding Factor β (CBFβ)–Smooth-Muscle Myosin Heavy Chain Sequesters CBFα2 into Cytoskeletal Filaments and Aggregates

Adya, N., Stacy, T., Speck, N. A., & Liu, P. P. (1998) · Molecular and Cellular Biology

Acute Myeloid Leukemia ResearchRetinoids in leukemia and cellular processes

Cited by 136

Auto-Inhibition of Ets-1 Is Counteracted by DNA Binding Cooperativity with Core-Binding Factor α2

Goetz, T. L., Gu, T.-L., Speck, N. A., & Graves, B. J. (2000) · Molecular and Cellular Biology

Genomics and Chromatin DynamicsDiffusion and Search Dynamics

Cited by 128

T-lymphoid, megakaryocyte, and granulocyte development are sensitive to decreases in CBFβ dosage.

Talebian, L., Li, Z., Guo, Y., Gaudet, J., Speck, M. E., Sugiyama, D., Kaur, P., Pear, W. S., Maillard, I., & Speck, N. A. (2007) · Blood

T-cell and B-cell ImmunologyHematopoietic Stem Cell Transplantation

Cited by 70

Rb family proteins enforce the homeostasis of quiescent hematopoietic stem cells by repressing Socs3 expression

Kim, E., Cheng, Y., Bolton-Gillespie, E., Cai, X., Ma, C., Tarangelo, A., Le, L., Jambhekar, M., Raman, P., Hayer, K. E., et al. (2017) · Journal of Experimental Medicine

Hematopoietic Stem Cell TransplantationCytokine Signaling Pathways and Interactions

Cited by 18