Of lineage and legacy: the development of mammalian hematopoietic stem cells
Open accessAbstract
The hematopoietic system is one of the first complex tissues to develop in the mammalian conceptus. Of particular interest in the field of developmental hematopoiesis is the origin of adult bone marrow hematopoietic stem cells. Tracing their origin is complicated because blood is a mobile tissue and because hematopoietic cells emerge from many embryonic sites. The origin of the adult mammalian blood system remains a topic of lively discussion and intense research. Interest is also focused on developmental signals that induce the adult hematopoietic stem cell program, as these may prove useful for generating and expanding these clinically important cell populations ex vivo. This review presents a historical overview of and the most recent data on the developmental origins of hematopoiesis.
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The cells used for in vitro differentiation and in vivo analysis in the reviewed work have all been derived from waves of hematopoiesis that begin with definitive hematopoietic stem cells, which first appear in the mouse fetal liver by about day 11.5 of gestation and may be followed by additional stem-cell waves through the end of gestation (day 20).
“The cells used for in vitro differentiation as well as in vivo analysis in the work reviewed above have all been derived from waves of hematopoiesis that begin with definitive hematopoietic stem cells, which first appear in the mouse fetal liver by about day 11.5 of gestation and may be followed by additional stem-cell waves through the end of gestation (day 20) (131).”
From Mechanisms of Action of Hematopoietic Transcription Factor PU.1 in Initiation of T-Cell Development (2019) · cites this paper as [131]
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- Authors
- Dzierzak, E., & Speck, N. A.
- Affiliations
- Erasmus MC (NL)
- Dartmouth College (US)
- Corresponding author
- Dzierzak, Elaine
- Speck, Nancy A
- Venue
- Nature Immunology
- Published
- 2008-01-18
- Volume
- 9
- Issue
- 2
- Pages
- 129-136
- ISSN
- 1529-2908 (ISSN-L)
- 1529-2916
- PMC
- PMC2696344
- OpenAlex
- W2144470070
- Cited by
- 707
- References
- 3
- Citations by year
- 2026: 9 · 2025: 21 · 2024: 23 · 2023: 36 · 2022: 26 · 2021: 27 · 2020: 29 · 2019: 31 · 2018: 37 · 2017: 47 · 2016: 58 · 2015: 49 · 2014: 55 · 2013: 50 · 2012: 49
- FWCI
- 7.00
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nature Immunology (publishedVersion)
- PubMed (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (publishedVersion)
- PubMed Central (acceptedVersion)
- Edinburgh Research Explorer (University of Edinburgh) (submittedVersion, other-oa)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
- RePub (Erasmus University Rotterdam) (submittedVersion, other-oa)
- RePub (Erasmus University Rotterdam) (submittedVersion)
- Funders
- ZonMw
- Fondation des Treilles
- National Institutes of Health
- National Heart, Lung, and Blood Institute (R01HL091724)
- National Cancer Institute (R01CA058343, P30CA023108)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK054077, R37DK054077, R37 DK54077)
- Topics
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
- Keywords
- hematopoietic stem cells, bone marrow, lineage tracing
- MeSH terms
- Animals, Embryo, Mammalian, Erythrocytes, Hematopoietic Stem Cells, Humans, Cell Lineage, Mice
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