Cole, Philip A.

Histone demethylation mediated by the nuclear amine oxidase homolog LSD1

Shi, Y., Lan, F., Matson, C., Mulligan, P., Whetstine, J. R., Cole, P. A., Casero, R. A., & Shi, Y. (2004) · Cell

Epigenetics and DNA MethylationGenomics and Chromatin Dynamics

Cited by 4,051

An allosteric mechanism for activation of the kinase domain of epidermal growth factor receptor

Zhang, X., Gureasko, J., Shen, K., Cole, P. A., & Kuriyan, J. (2006) · Cell

HER2/EGFR in Cancer ResearchProtein Kinase Regulation and GTPase Signaling

Cited by 1,650

Ghrelin

Müller, T. D., Nogueiras, R., Andermann, M. L., Andrews, Z. B., Anker, S. D., Argente, J., Batterham, R. L., Benoit, S. C., Bowers, C. Y., Broglio, F., et al. (2015) · Molecular Metabolism

Regulation of Appetite and ObesityGrowth Hormone and Insulin-like Growth Factors

Cited by 1,034

Acetylation of Tau Inhibits Its Degradation and Contributes to Tauopathy

Min, S.-W., Cho, S.-H., Zhou, Y., Schroeder, S., Haroutunian, V., Seeley, W. W., Huang, E. J., Shen, Y., Masliah, E., Mukherjee, C., et al. (2010) · Neuron

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 949

Discovery of a selective catalytic p300/CBP inhibitor that targets lineage-specific tumours

Lasko, L. M., Jakob, C. G., Edalji, R. P., Qiu, W., Montgomery, D., Digiammarino, E. L., Hansen, T. M., Risi, R. M., Frey, R., Manaves, V., et al. (2017) · Nature

Histone Deacetylase Inhibitors ResearchProtein Degradation and Inhibitors

Cited by 858

Virtual ligand screening of the p300/CBP histone acetyltransferase: identification of a selective small molecule inhibitor

Bowers, E. M., Yan, G., Mukherjee, C., Orry, A., Wang, L., Holbert, M. A., Crump, N. T., Hazzalin, C. A., Liszczak, G., Yuan, H., et al. (2010) · Chemistry & Biology

Histone Deacetylase Inhibitors ResearchComputational Drug Discovery Methods

Cited by 666

Regulation of the p300 HAT domain via a novel activation loop

Thompson, P. R., Wang, D., Wang, L., Fulco, M., Pediconi, N., Zhang, D., An, W., Ge, Q., Roeder, R. G., Wong, J., et al. (2004) · Nature Structural & Molecular Biology

Genomics and Chromatin DynamicsHistone Deacetylase Inhibitors Research

Cited by 423

Butyrate greatly enhances derivation of human induced pluripotent stem cells by promoting epigenetic remodeling and the expression of pluripotency-associated genes.

Mali, P., Chou, B.-K., Yen, J., Ye, Z., Zou, J., Dowey, S., Brodsky, R. A., Ohm, J. E., Yu, W., Baylin, S. B., et al. (2010) · Stem Cells

Pluripotent Stem Cells ResearchEpigenetics and DNA Methylation

Cited by 417

Inhibition of the EGF receptor by binding of MIG6 to an activating kinase domain interface

Zhang, X., Pickin, K. A., Bose, R., Jura, N., Cole, P. A., & Kuriyan, J. (2007) · Nature

HER2/EGFR in Cancer ResearchProtein Kinase Regulation and GTPase Signaling

Cited by 357

Mechanism and inhibition of cytochrome P-450 aromatase

Cole, P. A., & Robinson, C. H. (1990) · Journal of Medicinal Chemistry

Estrogen and related hormone effectsMetal-Catalyzed Oxygenation Mechanisms

Cited by 319

Site-Specific Incorporation of a Phosphotyrosine Mimetic Reveals a Role for Tyrosine Phosphorylation of SHP-2 in Cell Signaling

Lu, W., Gong, D., Bar-Sagi, D., & Cole, P. A. (2001) · Molecular Cell

Protein Tyrosine PhosphatasesProtein Kinase Regulation and GTPase Signaling

Cited by 268

The Leukemogenicity of AML1-ETO Is Dependent on Site-Specific Lysine Acetylation

Wang, L., Gural, A., Sun, X.-J., Zhao, X., Perna, F., Huang, G., Hatlen, M. A., Vu, L., Liu, F., Xu, H., et al. (2011) · Science

Acute Myeloid Leukemia ResearchRetinoids in leukemia and cellular processes

Cited by 242

p300/CBP-Associated Factor Selectively Regulates the Extinction of Conditioned Fear

Wei, W., Coelho, C. M., Li, X., Marek, R., Yan, S., Anderson, S., Meyers, D., Mukherjee, C., Sbardella, G., Castellano, S., et al. (2012) · The Journal of Neuroscience

Memory and Neural MechanismsNeuroscience and Neuropharmacology Research

Cited by 93

Inhibiting the coregulator CoREST impairs Foxp3+ Treg function and promotes antitumor immunity

Xiong, Y., Wang, L., Di Giorgio, E., Akimova, T., Beier, U. H., Han, R., Trevisanut, M., Kalin, J. H., Cole, P. A., & Hancock, W. W. (2020) · Journal of Clinical Investigation

T-cell and B-cell ImmunologyCancer Immunotherapy and Biomarkers

Cited by 72

Chemical Dissection of the Effects of Tyrosine Phosphorylation of SHP-2

Lu, W., Shen, K., & Cole, P. A. (2003) · Biochemistry

Protein Tyrosine PhosphatasesProtein Kinase Regulation and GTPase Signaling

Cited by 59

UM171 glues asymmetric CRL3–HDAC1/2 assembly to degrade CoREST corepressors

Yeo, M. J. R., Zhang, O., Xie, X., Nam, E., Payne, N. C., Gosavi, P. M., Kwok, H. S., Iram, I., Lee, C., Li, J., et al. (2025) · Nature

Protein Degradation and InhibitorsUbiquitin and proteasome pathways

Cited by 58

Converging mechanism of UM171 and KBTBD4 neomorphic cancer mutations

Xie, X., Zhang, O., Yeo, M. J. R., Lee, C., Tao, R., Harry, S. A., Payne, N. C., Nam, E., Paul, L., Li, Y., et al. (2025) · Nature

Protein Degradation and InhibitorsUbiquitin and proteasome pathways

Cited by 50

PH domain-mediated autoinhibition and oncogenic activation of Akt

Bae, H., Viennet, T., Park, E., Chu, N., Salguero, A., Eck, M. J., Arthanari, H., & Cole, P. A. (2022) · eLife

PI3K/AKT/mTOR signaling in cancerProtein Kinase Regulation and GTPase Signaling

Cited by 31

PH Domain-Mediated Autoinhibition and Oncogenic Activation of Akt

Bae, H., Viennet, T., Park, E., Chu, N., Salguero, A. L., Eck, M. J., Arthanari, H., & Cole, P. A. (2022) · eLife

PI3K/AKT/mTOR signaling in cancerProtein Kinase Regulation and GTPase Signaling

Cited by 31

Inhibition of ghrelin O-acyltransferase attenuates food deprivation-induced increases in ingestive behavior

Teubner, B. J. W., Garretson, J. T., Hwang, Y., Cole, P. A., & Bartness, T. J. (2013) · Hormones and Behavior

Regulation of Appetite and ObesityHypothalamic control of reproductive hormones

Cited by 21

Structural requirements for activity of Mind bomb1 in Notch signaling

Cao, R., Gozlan, O., Airich, A., Tveriakhina, L., Zhou, H., Jiang, H., Cole, P. A., Aster, J. C., Klein, T., Sprinzak, D., et al. (2024) · Structure

Ubiquitin and proteasome pathwaysDevelopmental Biology and Gene Regulation

Cited by 7

Structural Requirements for Activity of Mind bomb1 in Notch Signaling

Cao, R., Gozlan, O., Tveriakhina, L., Zhou, H., Jiang, H., Cole, P. A., Aster, J. C., Sprinzak, D., & Blacklow, S. C. (2024) · Structure

Ubiquitin and proteasome pathwaysDevelopmental Biology and Gene Regulation

Cited by 7