Spooner, Eric

PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase

Sancak, Y., Thoreen, C. C., Peterson, T. R., Lindquist, R. A., Kang, S. A., Spooner, E., Carr, S. A., & Sabatini, D. M. (2007) · Molecular Cell

PI3K/AKT/mTOR signaling in cancerMetabolism, Diabetes, and Cancer

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The Folliculin Tumor Suppressor Is a GAP for the RagC/D GTPases That Signal Amino Acid Levels to mTORC1

Tsun, Z.-Y., Bar-Peled, L., Chantranupong, L., Zoncu, R., Wang, T., Kim, C., Spooner, E., & Sabatini, D. M. (2013) · Molecular Cell

PI3K/AKT/mTOR signaling in cancerAutophagy in Disease and Therapy

Cited by 565

The Sestrins Interact with GATOR2 to Negatively Regulate the Amino-Acid-Sensing Pathway Upstream of mTORC1

Chantranupong, L., Wolfson, R. L., Orozco, J. M., Saxton, R. A., Scaria, S. M., Bar-Peled, L., Spooner, E., Isasa, M., Gygi, S. P., & Sabatini, D. M. (2014) · Cell Reports

PI3K/AKT/mTOR signaling in cancerAutophagy in Disease and Therapy

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Helicobacter pylori cytotoxin-associated gene A (CagA) subverts the apoptosis-stimulating protein of p53 (ASPP2) tumor suppressor pathway of the host

Buti, L., Spooner, E., Van der Veen, A. G., Rappuoli, R., Covacci, A., & Ploegh, H. L. (2011) · Proceedings of the National Academy of Sciences

Helicobacter pylori-related gastroenterology studiesCancer-related Molecular Pathways

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Cyclophilin A supports translation of intrinsically disordered proteins and affects haematopoietic stem cell ageing

Maneix, L., Iakova, P., Lee, C. G., Moree, S. E., Lu, X., Datar, G. K., Hill, C. T., Spooner, E., King, J. C. K., Sykes, D. B., et al. (2024) · Nature Cell Biology

Heat shock proteins researchSignaling Pathways in Disease

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