PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase

TOR signaling in growth and metabolism

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TSC2 Mediates Cellular Energy Response to Control Cell Growth and Survival

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mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery.

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TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

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Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action.

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Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling

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Growing roles for the mTOR pathway

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Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway

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Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex

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mTOR and cancer: insights into a complex relationship

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Phosphorylation and Functional Inactivation of TSC2 by Erk

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Tuberous Sclerosis Complex Gene Products, Tuberin and Hamartin, Control mTOR Signaling by Acting as a GTPase-Activating Protein Complex toward Rheb

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Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40

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RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1

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The TSC1-2 tumor suppressor controls insulin–PI3K signaling via regulation of IRS proteins

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Insulin Activation of Rheb, a Mediator of mTOR/S6K/4E-BP Signaling, Is Inhibited by TSC1 and 2

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Phosphorylation of the Translational Repressor PHAS-I by the Mammalian Target of Rapamycin

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Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins

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Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling

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Tsc tumour suppressor proteins antagonize amino-acid–TOR signalling

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The Mammalian Target of Rapamycin (mTOR) Partner, Raptor, Binds the mTOR Substrates p70 S6 Kinase and 4E-BP1 through Their TOR Signaling (TOS) Motif

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Rheb promotes cell growth as a component of the insulin/TOR signalling network

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Rheb is an essential regulator of S6K in controlling cell growth in Drosophila

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TOS Motif-Mediated Raptor Binding Regulates 4E-BP1 Multisite Phosphorylation and Function

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Rheb Binds Tuberous Sclerosis Complex 2 (TSC2) and Promotes S6 Kinase Activation in a Rapamycin- and Farnesylation-dependent Manner

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Identification of a Proline-rich Akt Substrate as a 14-3-3 Binding Partner

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Rheb Binding to Mammalian Target of Rapamycin (mTOR) Is Regulated by Amino Acid Sufficiency

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The hypoxia-induced paralogs Scylla and Charybdis inhibit growth by down-regulating S6K activity upstream of TSC in DrosophilaPreprint

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The Stress-inducted Proteins RTP801 and RTP801L Are Negative Regulators of the Mammalian Target of Rapamycin Pathway

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Inactivation of the Tuberous Sclerosis Complex-1 and -2 Gene Products Occurs by Phosphoinositide 3-Kinase/Akt-dependent and -independent Phosphorylation of Tuberin

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Transcript map of the 3.7-Mb D19S112-D19S246 candidate tumor suppressor region on the long arm of chromosome 19.

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Lobe mediates Notch signaling to control domain-specific growth in the Drosophila eye disc

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Expression of proline-rich Akt-substrate PRAS40 in cell survival pathway and carcinogenesis1

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mTOR Signaling in Growth Control and Disease

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mTOR Signaling in Growth, Metabolism, and Disease

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AKT/PKB signaling: navigating downstream

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mTOR: from growth signal integration to cancer, diabetes and ageing

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AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint

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AKT/PKB Signaling: Navigating the Network

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mTOR at the nexus of nutrition, growth, ageing and disease

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The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1

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Defining the role of mTOR in cancer

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Molecular mechanisms of mTOR-mediated translational control

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Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids

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mTOR signaling at a glance

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MTOR: a pharmacologic target for autophagy regulation

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Nutrient-dependent mTORC1 Association with the ULK1–Atg13–FIP200 Complex Required for Autophagy

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Targeting cancer stem cell pathways for cancer therapy

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An ATP-competitive Mammalian Target of Rapamycin Inhibitor Reveals Rapamycin-resistant Functions of mTORC1

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The PI3K/AKT Pathway in Obesity and Type 2 Diabetes

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mTOR controls mitochondrial oxidative function through a YY1–PGC-1α transcriptional complex

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SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth

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Anti-inflammatory effect of IL-10 mediated by metabolic reprogramming of macrophages

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Regulation of TORC1 by Rag GTPases in nutrient response

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Regulation of the mTOR Complex 1 Pathway by Nutrients, Growth Factors, and Stress

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The TSC1–TSC2 complex: a molecular switchboard controlling cell growth

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mTOR Complex 1 Regulates Lipin 1 Localization to Control the SREBP Pathway

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DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival

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mTOR as a central hub of nutrient signalling and cell growth

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mTOR kinase structure, mechanism and regulation

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Regulation and function of mTOR signalling in T cell fate decisions

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Regulation and function of ribosomal protein S6 kinase (S6K) within mTOR signalling networks

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Translational control of long-lasting synaptic plasticity and memory

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mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)

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Metformin, independent of AMPK, inhibits mTORC1 in a rag GTPase-dependent manner

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The PTEN–PI3K pathway: of feedbacks and cross-talks

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Regulation of mTORC1 by PI3K Signaling

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The mTOR Signalling Pathway in Human Cancer

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The amino acid transporter SLC38A9 is a key component of a lysosomal membrane complex that signals arginine sufficiency to mTORC1

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Rapamycin differentially inhibits S6Ks and 4E-BP1 to mediate cell-type-specific repression of mRNA translation

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Regulation of mTORC1 by amino acids

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AMPK and mTOR in Cellular Energy Homeostasis and Drug Targets

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Spatial Control of the TSC Complex Integrates Insulin and Nutrient Regulation of mTORC1 at the Lysosome

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The Neurology of mTOR

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Signal integration by mTORC1 coordinates nutrient input with biosynthetic output

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The Targets of Curcumin

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Hypoxia regulates TSC1/2–mTOR signaling and tumor suppression through REDD1-mediated 14–3–3 shuttling

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PI3K/Akt: getting it right matters

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LKB1 and AMP-activated protein kinase control of mTOR signalling and growth

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Stress granules and cell signaling: more than just a passing phase?

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TBC1D7 Is a Third Subunit of the TSC1-TSC2 Complex Upstream of mTORC1

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Dual Specificity Kinase DYRK3 Couples Stress Granule Condensation/Dissolution to mTORC1 Signaling

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Antitumor activity of rapamycin in a Phase I trial for patients with recurrent PTEN-deficient glioblastoma

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The Folliculin Tumor Suppressor Is a GAP for the RagC/D GTPases That Signal Amino Acid Levels to mTORC1

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mTORC1 as the main gateway to autophagy

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